Yang Liu

Yang Liu, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Lab

Research Interests

  • Single-Molecule Biophysics
  • Cell Dynamics
  • DNA Repair
  • Immunity
  • Nucleic Acids
  • Biotechnology Development
  • Genome Editing

Research Statement

We study how cellular machinery detects, signals, and repairs DNA damage by marrying state-of-the-art chemical biology, biophysical, and genetic techniques.

Education History

Graduate Training Emory University
 PhD
Undergraduate Hunan University
 BS

Selected Publications

Journal Article

  1. He S, Huang Z, Liu Y, Ha T, Wu B (2024). DNA break induces rapid transcription repression mediated by proteasome-dependent RNAPII removal. Cell Rep, 43(7), 114420.
  2. Mortenson KL, Dawes C, Wilson ER, Patchen NE, Johnson HE, Gertz J, Bailey SD, Liu Y, Varley KE, Zhang X (2024). 3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression. Nat Commun, 15(1), 6130.
  3. Blake LA, Watkins L, Liu Y, Inoue T, Wu B (2024). A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies. Nat Commun, 15(1), 2720.
  4. Zou RS, Liu Y, Gaido OER, Konig MF, Mog BJ, Shen LL, Aviles-Vazquez F, Marin-Gonzalez A, Ha T (2023). Improving the sensitivity of in vivo CRISPR off-target detection with DISCOVER-Seq. Nat Methods, 20(5), 706-713.
  5. Zou RS, Marin-Gonzalez A, Liu Y, Liu HB, Shen L, Dveirin RK, Luo JXJ, Kalhor R, Ha T (2022). Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Nat Cell Biol, 24(9), 1433-1444.
  6. Zou RS, Liu Y, Wu B, Ha T (2021). Cas9 deactivation with photocleavable guide RNAs. Mol Cell, 81(7), 1553-1565.e8.
  7. Liu Y, Zou RS, He S, Nihongaki Y, Li X, Razavi S, Wu B, Ha T (2019). Very fast CRISPR on demand. Science, 368(6496), 1265-1269.
  8. Wiegand T, Fratini M, Frey F, Yserentant K, Liu Y, Weber E, Galior K, Ohmes J, Braun F, Herten DP, Boulant S, Schwarz US, Salaita K, Cavalcanti-Adam EA, Spatz JP (2020). Forces during cellular uptake of viruses and nanoparticles at the ventral side. Nat Commun, 11(1), 32.
  9. Liu Y, Blanchfield L, Ma VP, Andargachew R, Galior K, Liu Z, Evavold B, Salaita K (2016). DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity. Proc Natl Acad Sci U S A, 113(20), 5610-5.
  10. Yehl K, Mugler A, Vivek S, Liu Y, Zhang Y, Fan M, Weeks ER, Salaita K (2015). High-speed DNA-based rolling motors powered by RNase H. Nat Nanotechnol, 11(2), 184-90.
  11. Liu Z, Liu Y, Chang Y, Seyf HR, Henry A, Mattheyses AL, Yehl K, Zhang Y, Huang Z, Salaita K (2015). Nanoscale optomechanical actuators for controlling mechanotransduction in living cells. Nat Methods, 13(2), 143-6.
  12. Liu Y, Yehl K, Narui Y, Salaita K (2013). Tension sensing nanoparticles for mechano-imaging at the living/nonliving interface. J Am Chem Soc, 135(14), 5320-3.

Review

  1. Liu Y, Cottle WT, Ha T (2023). Mapping cellular responses to DNA double-strand breaks using CRISPR technologies. [Review]. Trends Genet, 39(7), 560-574.
  2. Biswas J, Liu Y, Singer RH, Wu B (2019). Fluorescence Imaging Methods to Investigate Translation in Single Cells. [Review]. Cold Spring Harb Perspect Biol, 11(4).