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Yang Liu

Yang Liu, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Academic Office Information

Research Interests

  • Single-Molecule Biophysics
  • Cell Dynamics
  • DNA Repair
  • Immunity
  • Nucleic Acids
  • Biotechnology Development
  • Genome Editing

Research Statement

We study how cellular machinery detects, signals, and repairs DNA damage by marrying state-of-the-art chemical biology, biophysical, and genetic techniques.

Education History

Fellowship Johns Hopkins University School of Medicine
Postdoctoral Fellow
Emory University
Undergraduate Hunan University

Selected Publications

Journal Article

  1. Roger S Zou, Alberto Marin-Gonzalez, Yang Liu, Hans B Liu, Leo Shen, Rachel K Dveirin, Jay XJ Luo, Reza Kalhor, Taekjip Ha (2022). Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Nat Cell Biol, (24), 1433-1444.
  2. Zou RS, Liu Y, Wu B, Ha T (2021). Cas9 deactivation with photocleavable guide RNAs. Mol Cell, 81(7), 1553-1565.e8. (Read full article)
  3. Liu Y, Zou RS, He S, Nihongaki Y, Li X, Razavi S, Wu B, Ha T (2019). Very fast CRISPR on demand. Science, 368(6496), 1265-1269. (Read full article)
  4. Wiegand T, Fratini M, Frey F, Yserentant K, Liu Y, Weber E, Galior K, Ohmes J, Braun F, Herten DP, Boulant S, Schwarz US, Salaita K, Cavalcanti-Adam EA, Spatz JP (2020). Forces during cellular uptake of viruses and nanoparticles at the ventral side. Nat Commun, 11(1), 32. (Read full article)
  5. Liu Y, Blanchfield L, Ma VP, Andargachew R, Galior K, Liu Z, Evavold B, Salaita K (2016). DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity. Proc Natl Acad Sci U S A, 113(20), 5610-5. (Read full article)
  6. Yehl K, Mugler A, Vivek S, Liu Y, Zhang Y, Fan M, Weeks ER, Salaita K (2015). High-speed DNA-based rolling motors powered by RNase H. Nat Nanotechnol, 11(2), 184-90. (Read full article)
  7. Liu Z, Liu Y, Chang Y, Seyf HR, Henry A, Mattheyses AL, Yehl K, Zhang Y, Huang Z, Salaita K (2015). Nanoscale optomechanical actuators for controlling mechanotransduction in living cells. Nat Methods, 13(2), 143-6. (Read full article)
  8. Liu Y, Yehl K, Narui Y, Salaita K (2013). Tension sensing nanoparticles for mechano-imaging at the living/nonliving interface. J Am Chem Soc, 135(14), 5320-3. (Read full article)


  1. Biswas J, Liu Y, Singer RH, Wu B (2019). Fluorescence Imaging Methods to Investigate Translation in Single Cells. [Review]. Cold Spring Harb Perspect Biol, 11(4). (Read full article)