Zeinab A. Afify

Zeinab A. Afify, MD

Languages spoken: English, Arabic

Academic Information

Departments Adjunct - Pediatrics

Academic Office Information

zeinab.afify@hsc.utah.edu

Board Certification

  • American Board of Pediatrics (Pediatrics)
  • American Board of Pediatrics (Sub: Pediatric Hematology-Oncology)

Research Interests

  • Histiocytosis, Langerhans-Cell
  • Post-Transplant Lymphoproliferative Disease
  • Non-Hodgkin Lymphoma
  • Hemophagocytic Lymphohistiocytosis

Dr. Afify received her medical degree from University of Alexandria, Egypt, Faculty of Medicine. She completed her Pediatric residency and Pediatric Hematology Oncology fellowship in Riley Hospital for Children, Indiana University.

She was on the faculty in the department of Pediatrics in Alexandria University for 10 years. She also took clinical appointments in Australia and in United Kingdom.


Since 2002 Dr. Afify has been faculty member of the department of Pediatrics, Division of Pediatric Hematology Oncology at the University of Utah and is in is currently an Associate Professor. Dr. Afify is board-certified in Pediatrics and Pediatric Hematology Oncology.


Her clinical and research interests include Pediatric Non-Hodgkin’s lymphoma and post solid organ transplant lymphoproliferative disease (PTLD). She is an a member of the Editorial Board American Academy of Pediatrics (AAP). PREP Hematology Oncology Section and member of Leukemia/Lymphoma/lymphoproliferative Work Group. American Academy of Pediatrics (AAP) and American Society of Pediatric Hematology Oncology (ASPHO) policy Group.

Research Statement

My Academic and research interests are focused on pediatric non-Hodgkin lymphoma (NHL) and post solid organ transplant lymphoproliferative disease (PTLD). I am a member and coinvestigator in Children’s Oncology Group (COG) NHL committee, a past coinvestigator on 2 past clinical trials and 2 currently in development. I am currently leading a multi institutional study of monomorphic PTLD. Three subtypes o PTLD are understudy, Burkitt lymphoma occuring in the setting of PTLD, EBV negative monomorphic PTLD/diffuse large B cell lymphoma (DLBCL) and central nervous system positive PTLD.

Education History

Fellowship Children's Hospital of Westmead
 Clinical Fellow
Riley Hospital for Children
 Resident
Fellowship Riley Hospital for Children
 Fellow
University of Iowa Hospitals and Clinics
 Clinical Fellow
Research Fellow Emory University School of Medicine
 Research Fellow
University of Alexandria Children's Hospital
 Resident
Internship University of Alexandria Hospitals
 Intern
University of Alexandria
 MBBCh

Selected Publications

Journal Article

  1. Iglesias Cardenas F, Agarwal AM, Vagher J, Maese L, Fluchel M, Afify Z (2021). Two Clonally Distinct B-Cell Lymphomas Reveal the Diagnosis of XLP1 in a Male Child and His Asymptomatic Male Relatives: Case Report and Review of the Literature. J Pediatr Hematol Oncol, 43(8), e1210-e1213. (Read full article)
  2. Giulino-Roth L, ODonohue T, Chen Z, Bartlett NL, LaCasce A, Martin-Doyle W, Barth MJ, Davies K, Blum KA, Christian B, Casulo C, Smith SM, Godfrey J, Termuhlen A, Oberley MJ, Alexander S, Weitzman S, Appel B, Mizukawa B, Svoboda J, Afify Z, Pauly M, Dave H, Gardner R, Stephens DM, Zeitler WA, Forlenza C, Levine J, Williams ME, Sima JL, Bollard CM, Leonard JP (2017). Outcomes of adults and children with primary mediastinal B-cell lymphoma treated with dose-adjusted EPOCH-R. Br J Haematol, 179(5), 739-747. (Read full article)
  3. Bruggers CS, Bleyl SB, Pysher T, Barnette P, Afify Z, Walker M, Biegel JA (2011). Clinicopathologic comparison of familial versus sporadic atypical teratoid/rhabdoid tumors (AT/RT) of the central nervous system. Pediatr Blood Cancer, 56(7), 1026-31. (Read full article)

Case Report

  1. Carter-Febres M, Smock KJ, Ware AL, Afify ZA (2020). Improvement of Bleeding Manifestations of Acquired Von Willebrand Syndrome after Balloon Aortic Valvoplasty in a child with Aortic Stenosis.  https://doi.org/10.1016/j.ppedcard.2020.101334. Prog Pediatr Cardiol.
  2. Gallagher-Lacey C, Afify Z, Yaish HM, Yoder BA, Christensen RD (2017). An Instructive Case of Transient Myeloproliferative Disorder. Clin Pediatr (Phila), 56(3), 288-289. (Read full article)
  3. Zhou D, Paxton CN, Kelley TW, Afify Z, South ST, Miles RR (2016). Two Unrelated Burkitt Lymphomas Seven Years Apart in a Patient With X-Linked Lymphoproliferative Disease Type 1 (XLP1). Am J Clin Pathol, 146(2), 248-53. (Read full article)
  4. Meznarich J, Miles R, Paxton CN, Afify Z (2016). Pediatric B-Cell Lymphoma With Lymphoblastic Morphology, TdT Expression, MYC Rearrangement, and Features Overlapping With Burkitt Lymphoma. Pediatr Blood Cancer, 63(5), 938-40. (Read full article)
  5. Miles RR, Afify Z, Yaish H, Perkins SL (2010). CD56-negative extranodal nasal type NK/T-cell lymphoma. Pediatr Blood Cancer, 55(1), 186-9. (Read full article)
  6. Niazi TN, Forester C, Afify Z, Riva-Cambrin J (2009). Osteosarcoma presenting as hemorrhagic cerebellar metastasis. Childs Nerv Syst, 25(12), 1643-7. (Read full article)
  7. Cole B, Zhou H, McAllister N, Afify Z, Coffin CM (2006). Inflammatory myofibroblastic tumor with thrombocytosis and a unique chromosomal translocation With ALK rearrangement. Arch Pathol Lab Med, 130(7), 1042-5. (Read full article)

Letter

  1. Carter Febres M, Abbott J, Cipriano SD, Knackstedt ED, George TI, Afify Z (2020). Drug reaction with eosinophilia and systemic symptoms (DRESS)-associated hemophagocytic lymphohistiocytosis (HLH), an important and underrecognized HLH mimic: A case report. [Letter to the editor]. Pediatr Blood Cancer, 68(2), e28657. (Read full article)
  2. Febres MC, Viskochil D, Rampton J, Afify Z (2020). Further Lessons Learned From a Child With NF1 and Classical Hodgkin Lymphoma. [Letter to the editor]. J Pediatr Hematol Oncol. (Read full article)

Abstract

  1. Ampofo K, Korgensk K, Meyers R (2014). International Society of Pediatric Oncology SIOP 46th Congress Toronto, Canada [Abstract]. Pediatric Blood & Cancer, 61(S2).
  2. Afify Z, Barnhart D (2012). Role of Second Look Surgery in Residual Abdominal Mass in mature B-Cell Non-Hodgkin's Lymphoma in children. Fourth International Symposium for Children and Adolescent Non-Hodgkin's Lymphoma, New York, NY [Abstract]. British Journal of Hematology, 159(Suppl), 72.
  3. Whipple N, Afify Z, Schiffman J, Bruggers C (2012). Extra-Gonadal Familial Germ Cell Tumors in Two male Children. American Society of Pediatric Hematology/Oncology 25th Annual Meeting, New Orleans, LA [Abstract]. Pediatric Blood & Cancer, 58(7), 1071.
  4. Bruggers C, Afify Z, Levin J (2012). Impact of Osteonecrosis on Quality of Life in Survivors of Childhood Acut Lymphoblastic Leukemia. American Society of Pediatric Hematology/Oncology 25th Annual Meeting, New Orleans, LA [Abstract]. Pediatric Blood & Cancer, 58(7), 1091.
  5. Meyers R, Afify Z (2010). Retroperitoneal Kaposiform Hemangioendothelioma: Review of the medical literature and surgical management options International Society of Pediatric Oncology SIOP 42nd Congress Boston, MA [Abstract]. Pediatric Blood & Cancer, 55(5), 904.
  6. Meyers R, Afify Z (2010). Outcome of Relapsed mature B-Cell Non-Hodgkin's Lymphoma. International Society of Pediatric Oncology SIOP 42nd Congress Boston, MA [Abstract]. Pediatric Blood & Cancer, 55(5), 869.
  7. Afify Z, Bruggers C, Barnette P, Book L, Perkins S (2009). Post Organ Transplantation Lymphoproliferative disease (PTLD). A Single Institution Experience. Proceedings of the Third international Meeting on Pediatric and Adolescent Non-Hodgkin's Lymphoma, Frankfurt Germany [Abstract]. Hematology meeting reports, 3(5), 154.
  8. Afify Z, Barnette P, Yaish H, Perkins S (2009). Clinical Features and Outcome of Recurrent Anaplastic Large Cell Lymphoma (ALCL) In Children and Adolescents. Proceedings of the Third international Meeting on pediatric and Adolescent Non-Hodgkin's Lymphoma, Frankfurt, Germany [Abstract]. Hematology Meeting reports, 3(5), 96.
  9. Miles RR, Afify Z, yaish H, Perkins S (2009). CD56-Negative extranodal NK/T-cel Lymphoma, Nasal Type, in a Pediatric Patient: A case Report, Proceedings of the Third international Meeting on Pediatric and adolescent Non-Hodgkin's Lymphoma, Frankfurt, Germany [Abstract]. Hematology meeting Reports, 3(5), 118.
  10. Bruggers C, Barentte P, Pysher T, Afify Z, Walker M, Bleyl S, Biegel J (2009). Clinicopathologic Comparison of Familial versus Sporadic Atypical Teratoid/Rhabdoid Tumors (AT/RT) of the Central Nervous System: the Utah experience. American Society of Pediatric Hematology Oncology (ASPHO) annual meeting [Abstract]. Pediatric Blood and Cancer, 52(6), 733.
  11. Afify Z, Lobb R, Feola P (2005). Experience with Arm Ports in Pediatric Patients with Hematological and Oncological disorders in a Single Institution. SIOP meeting vancouver, Canada [Abstract]. Pediatric Blood and cancer, 45(4), 512.
  12. Afify Z, Ampofo K, Korgensk K (2005). The Expanding Spectrum of central Venous Catheter Related Infection by Non-Tuberculous Mycobacteria in Immunocompromised Children with Cancer. SIOP meeting Vancouver, Canada [Abstract]. Pediatric Blood and Cancer, 45(4), 512.
  13. Afify Z, Jacobsz A, Matta H, Khatib F (2001). Surgical Emergencies in Pediatric Burkitt's Lymphoma. Presented at the IPSO Meeting, October [Abstract]. Medical and Pediatric Oncology, 37(3), 341.
  14. Afify Z, Khatib F, Bener A, Castella A (2001). Clinical and Epidemiological Features of Pediatric Hodgkin's Disease in the United Arab Emirates (UAE). Presented at the SIOP Meeting, October [Abstract]. Medical and Pediatric Oncology, 37(3), 293.
  15. Afify Z, Raaschou T, Castella A, Kristensen J, Zwaan F (2001). Familial Hodgkin's Disease in Three Full Siblings. Presented at the SIOP Meeting, October [Abstract]. Medical and Pediatric Oncology, 37(3), 313.
  16. Hesketh E, Shaw P, Afify Z, Gilbert L, Ratnamoham, Burgess M (2001). A Cross Sectional Study to Look at Parvovirus B19 Infection in Children with Acute Lymphoblastic Leukemia. Presented at the SIOP Meeting, October, by Dr. Hesketh [Abstract]. Medical and Pediatric Oncology, 37(3), 262.
  17. Trad O, Jumaa P, Afify Z (2000). The Changing Pattern of Organisms Isolated from Blood cultures in Pediatric Oncology Patients in the United Arab Emirates. International Society of Pediatric Oncology (SIOP) meeting, Amsterdam, Holland [Abstract]. Medical and Pediatric Oncology, 37(3), 313.