Dean Tantin

Dean Tantin, PhD

Languages spoken: English

Academic Information

Departments Primary - Pathology

Lab

Dean Tantin is a Professor in the Department of Pathology at the University of Utah School of Medicine and a member of the Nuclear Control of Cell Growth and Differentiation Program at the Huntsman Cancer Institute.

Tantin studies the regulation of gene expression and its relationship to immune and stem cell function. He focuses on a class of transcription factors that has been tied to cellular reprogramming and immune function. Examples of these proteins are Oct1/Pou2f1, Oct2/Pou2f1, and Oct4/Pou5f1. These proteins interact with multiple cofactors (an example is the OCA-B protein) that control local chromatin and gene expression to regulate gene expression through mechanisms that make them attractive drug candidates.

Tantin received a B.S. in Molecular Biology from the University of California, San Diego and a Ph.D. in Molecular Biology from UCLA. He was a Postdoctoral Fellow at the Massachusetts Institute of Technology Center for Cancer Reseach and Department of Biology under Nobel Laureate Phil Sharp.

Education History

Undergraduate University of California, San Diego Division of Biology
 BS
Doctoral Training University of California, Los Angeles, Molecular Biology Institute Interdepartmental Ph.D. Program
 PhD
Postdoctoral Fellowship Massachusetts Institute of Technology, Center for Cancer Research
 Postdoctoral Fellow
Postdoctoral Training Massachusetts Institute of Technology Center for Cancer Research
 Postdoctoral Associate
Postdoctoral Fellowship Massachusetts Institute of Technology Center for Cancer Research
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Kiesler P, Shakya A, Tantin D, Vercelli (2009). An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression. Human molecular genetics, 18(23), 4513-20.
  2. Jafek JL, Shakya A, Tai PY, Ibarra A, Kim H, Maddox J, Chumley J, Spangrude GJ, Miles RR, Kelley TW, Tantin (2019). Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia. Experimental hematology, 76, 38-48.e2.
  3. Kang J, Shen Z, Lim JM, Handa H, Wells L, Tantin (2013). Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation. FASEB journal, 27(7), 2807-17.
  4. Kang J, Gemberling M, Nakamura M, Whitby FG, Handa H, Fairbrother WG, Tantin (2009). A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes & development, 23(2), 208-22.
  5. Shakya A, Kang J, Chumley J, Williams MA, Tantin (2011). Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. The Journal of biological chemistry, 286(1), 450-9.
  6. Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA, Tantin (2015). Oct1 and OCA-B are selectively required for CD4 memory T cell function. The Journal of experimental medicine, 212(12), 2115-31.
  7. Kim H, Perovanovic J, Shakya A, Shen Z, German CN, Ibarra A, Jafek JL, Lin NP, Evavold BD, Chou DH, Jensen PE, He X, Tantin (2021). Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes. The Journal of experimental medicine, 218(3),
  8. Li Q, Shakya A, Guo X, Zhang H, Tantin D, Jensen PE, Chen (2012). Constitutive nuclear localization of NFAT in Foxp3+ regulatory T cells independent of calcineurin activity. Journal of immunology (Baltimore, Md., 188(9), 4268-77.
  9. Shakya A, Callister C, Goren A, Yosef N, Garg N, Khoddami V, Nix D, Regev A, Tantin (2015). Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion. Molecular and cellular biology, 35(6), 1014-25.
  10. Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev (2013). Dynamic regulatory network controlling TH17 cell differentiation. Nature, 496(7446), 461-8.
  11. Ferraris L, Stewart AP, Kang J, DeSimone AM, Gemberling M, Tantin D, Fairbrother W (2011). Combinatorial binding of transcription factors in the pluripotency control regions of the genome. Genome research, 21(7), 1055-64.
  12. Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin (2009). Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nature cell biology, 11(3), 320-7.
  13. Manning J, Mitchell B, Appadurai DA, Shakya A, Pierce LJ, Wang H, Nganga V, Swanson PC, May JM, Tantin D, Spangrude G (2013). Vitamin C promotes maturation of T-cells. Antioxidants & redox signaling, 19(17), 2054-67.
  14. Vazquez-Arreguin K, Maddox J, Kang J, Park D, Cano RR, Factor RE, Ludwig T, Tantin (2018). BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism. Molecular cancer research, 16(3), 439-452.
  15. Shen Z, Formosa T, Tantin (2018). FACT Inhibition Blocks Induction But Not Maintenance of Pluripotency. Stem cells and development, 27(24), 1693-1701.
  16. Kim H, Dickey L, Stone C, Jafek JL, Lane TE, Tantin (2019). T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response. Journal of neuroinflammation, 16(1), 133.
  17. Maddox J, Shakya A, South S, Shelton D, Andersen JN, Chidester S, Kang J, Gligorich KM, Jones DA, Spangrude GJ, Welm BE, Tantin (2012). Transcription factor Oct1 is a somatic and cancer stem cell determinant. PLoS genetics, 8(11), e1003048.
  18. Vázquez-Arreguín K, Bensard C, Schell JC, Swanson E, Chen X, Rutter J, Tantin (2019). Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy. PLoS genetics, 15(5), e1007687.
  19. Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter (2020). Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Cell metabolism, 31(2), 284-300.e7.
  20. Kang J, Goodman B, Zheng Y, Tantin (2011). Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination. PloS one, 6(8), e23872.
  21. Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter (2016). Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. eLife, 5,
  22. Shen Z, Kang J, Shakya A, Tabaka M, Jarboe EA, Regev A, Tantin (2017). Enforcement of developmental lineage specificity by transcription factor Oct1. eLife, 6, pii: e20937.
  23. McDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski (2019). Transcriptional regulatory model of fibrosis progression in the human lung. JCI insight, 4(22),
  24. Sun W, Guo J, McClellan D, Poeschla A, Bareyan D, Casey MJ, Cairns BR, Tantin D, Engel M (2022). GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia. Molecular cancer research, 20, 501-514.

Review

  1. Vazquez-Arreguin K, Tantin D (2016). The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks. [Review]. Biochim Biophys Acta, 1859, (6), 792-804.
  2. Tantin (2013). Oct transcription factors in development and stem cells: insights and mechanisms. Development (Cambridge, England), 140(14), 2857-66.
  3. Kang J, Shakya A, Tantin (2009). Stem cells, stress, metabolism and cancer: a drama in two Octs. Trends in biochemical sciences, 34(10), 491-9.
  4. Tantin D, Voth WP, Shakya (2013). Efficient chromatin immunoprecipitation using limiting amounts of biomass. Journal of visualized experiments, (75), e50064.

Book Chapter

  1. Maddox, J., Tantin, D (2013). Oct4, Oct1 and Cancer Stem Cells.

Editorial

  1. Tantin (2016). Good times for Oct proteins. Biochimica et biophysica acta, 1859(6), 769.

Other

  1. Sun W, Jia X, Liesa M, Tantin D, Ward D (2022). ABCB10 Loss Reduces CD4+ T Cell Activation and Memory Formation. Journal of immunology (Baltimore, Md., 208(2), 328-337.