Research Statement
Education History
Postdoctoral Fellowship |
Harvard Medical School and Brigham and Women's Hospital |
Postdoctoral Fellow |
---|---|---|
University of Minnesota |
PhD | |
Undergraduate |
University of Kansas |
BA |
Selected Publications
Journal Article
- Whiteside SK, Snook JP, Ma Y, Sonderegger FL, Fisher C, Petersen C, Zachary JF, Round JL, Williams MA, Weis JJ (2018). IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis. J Immunol, 200(4), 1457-1470. (Read full article)
- Paquette JK, Ma Y, Fisher C, Li J, Lee SB, Zachary JF, Kim YS, Teuscher C, Weis JJ (2017). Genetic Control of Lyme Arthritis by Borrelia burgdorferi Arthritis-Associated Locus 1 Is Dependent on Localized Differential Production of IFN-beta and Requires Upregulation of Myostatin. J Immunol, 199(10), 3525-3534. (Read full article)
- Bramwell KK, Mock K, Ma Y, Weis JH, Teuscher C, Weis JJ (2015). beta-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 Secretion in Response to Inflammatory Stimuli. J Immunol, 195(4), 1647-56. (Read full article)
- Lochhead RB, Zachary JF, Dalla Rosa L, Ma Y, Weis JH, OConnell RM, Weis JJ (2015). Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis. PLoS One, 10(8), e0135142. (Read full article)
- Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ (2014). Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/BxN serum transfer arthritis through intrinsic control of type I IFN production. J Immunol, 193(12), 6050-60. (Read full article)
- Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, OConnell RM, Weis JJ (2014). MicroRNA-146a Provides Feedback Regulation of Lyme Arthritis but Not Carditis during Infection with Borrelia burgdorferi. PLoS Pathog, 10(6), e1004212. (Read full article)
- Bramwell KK, Ma Y, Weis JH, Chen X, Zachary JF, Teuscher C, Weis JJ (2014). Lysosomal beta-glucuronidase regulates Lyme and rheumatoid arthritis severity. J Clin Invest, 124(1), 311-20. (Read full article)
- Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ (2012). Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. J Immunol, 189(5), 2488-501. (Read full article)
- Bramwell KK, Ma Y, Weis JH, Teuscher C, Weis JJ (2012). High-throughput genotyping of advanced congenic lines by high resolution melting analysis for identification of Bbaa2, a QTL controlling Lyme arthritis. Biotechniques, 52(3), 183-90. (Read full article)
- Sonderegger FL, Ma Y, Maylor-Hagan H, Brewster J, Huang X, Spangrude GJ, Zachary JF, Weis JH, Weis JJ (2012). Localized production of IL-10 suppresses early inflammatory cell infiltration and subsequent development of IFN-gamma-mediated Lyme arthritis. J Immunol, 188(3), 1381-93. (Read full article)
- Miller JC, Maylor-Hagen H, Ma Y, Weis JH, Weis JJ (2010). The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes. Infect Immun, 78(7), 3144-53. (Read full article)
- Ma Y, Miller JC, Crandall H, Larsen ET, Dunn DM, Weiss RB, Subramanian M, Weis JH, Zachary JF, Teuscher C, Weis JJ (2009). Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12. Infect Immun, 77(8), 3302-11. (Read full article)
- Miller JC, Ma Y, Bian J, Sheehan KC, Zachary JF, Weis JH, Schreiber RD, Weis JJ (2008). A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice. J Immunol, 181(12), 8492-503. (Read full article)
- Rogers SW, Weis JJ, Ma Y, Teuscher C, Gahring LC (2008). Mouse chromosome 11 harbors genetic determinants of hippocampal strain-specific nicotinic receptor expression. Hippocampus, 18(8), 750-7. (Read full article)
- Wang X, Ma Y, Yoder A, Crandall H, Zachary JF, Fujinami RS, Weis JH, Weis JJ (2008). T cell infiltration is associated with increased Lyme arthritis in TLR2-/- mice. FEMS Immunol Med Microbiol, 52(1), 124-33. (Read full article)
- Stewart, PE, Wang, X, Bueschel DM, Clifton DR, Grimm, D, Tilly, K, Carroll JA, Weis JJ, Rosa PA (2006). Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian host. Infect Immun, (74), 3547-3553.
- Crandall H, Ma Y, Dunn DM, Sundsbak RS, Zachary JF, Olofsson P, Holmdahl R, Weis JH, Weiss RB, Teuscher C, Weis JJ (2005). Bb2Bb3 Regulation of Murine Lyme Arthritis Is Distinct from Ncf1 and Independent of the Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase. Am J Pathol, 167(3), 775-85. (Read full article)
- Wang X, Ma Y, Weis JH, Zachary JF, Kirschning CJ, Weis JJ (2005). Relative contributions of innate and acquired host responses to bacterial control and arthritis development in Lyme disease. Infect Immun, 73(1), 657-60. (Read full article)
- Bolz DD, Sundsbak RS, Ma Y, Akira S, Kirschning CJ, Zachary JF, Weis JH, Weis JJ (2004). MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. J Immunol, 173(3), 2003-10. (Read full article)
- Wooten RM, Ma Y, Yoder RA, Brown JP, Weis JH, Zachary JF, Kirschning CJ, Weis JJ (2002). Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J Immunol, 168(1), 348-55. (Read full article)
- Roper RJ, Weis JJ, McCracken BA, Green CB, Ma Y, Weber KS, Fairbairn D, Butterfield RJ, Potter MR, Zachary JF, Doerge RW, Teuscher C (2001). Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun, 2(7), 388-97. (Read full article)
- Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, Qureshi N, Michalek SM, Vogel SN (2001). Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun, 69(3), 1477-82. (Read full article)
- Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ (2000). Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J Immunol, 165(2), 618-22. (Read full article)
- Brown JP, Zachary JF, Teuscher C, Weis JJ, Wooten RM (1999). Dual role of interleukin-10 in murine Lyme disease: regulation of arthritis severity and host defense. Infect Immun, 67(10), 5142-50. (Read full article)
- Hirschfeld M, Kirschning CJ, Schwandner R, Wesche H, Weis JH, Wooten RM, Weis JJ (1999). Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol, 163(5), 2382-6. (Read full article)
- Morrison TB, Ma Y, Weis JH, Weis JJ (1999). Rapid and sensitive quantification of Borrelia burgdorferi-infected mouse tissues by continuous fluorescent monitoring of PCR. J Clin Microbiol, 37(4), 987-92. (Read full article)
- Weis JJ, McCracken BA, Ma Y, Fairbairn D, Roper RJ, Morrison TB, Weis JH, Zachary JF, Doerge RW, Teuscher C (1999). Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J Immunol, 162(2), 948-56. (Read full article)
Review
- Whiteside SK, Snook JP, Williams MA, Weis JJ (2018). Bystander T Cells: A Balancing Act of Friends and Foes. [Review]. Trends Immunol, 39(12), 1021-1035. (Read full article)
- Bramwell KK, Teuscher C, Weis JJ (2014). Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity. [Review]. Front Cell Infect Microbiol, 4, 76. (Read full article)
- Miller JC, Ma Y, Crandall H, Wang X, Weis JJ (2008). Gene expression profiling provides insights into the pathways involved in inflammatory arthritis development: murine model of Lyme disease. [Review]. Exp Mol Pathol, 85(1), 20-7. (Read full article)
- Bolz DD, Weis JJ (2004). Molecular mimicry to Borrelia burgdorferi: pathway to autoimmunity? [Review]. Autoimmunity, 37(5), 387-92. (Read full article)