Janis J. Weis, PhD
- Microbial Pathogenesis
- Genetic Regulation of Lyme Disease Severity
- Pathogenesis of Borrelia Burgdorferi
- Departments: Pathology - Professor
- Divisions: Microbiology and Immunology
Academic Office Information
Emma Eccles Jones Research Building
15 North Medical Drive East, Room: 1720B
Salt Lake City, UT 84112
Research StatementThe research in my laboratory is focused on understanding the means by which microbial infections result in acute and chronic inflammatory pathologies. We use the murine model of Lyme disease to assess the development of arthritis following infection by the spirochete Borrelia burgdorferi. We are taking two complementary approaches to identifying host responses that both permit chronic infection and result in arthritis. The first approach has centered on identifying the tissue-specific response to B. burgdorferi and its products that results in arthritis development. Comparison of responses in mouse strains destined to develop severe disease has revealed an exaggerated induction of interferon-inducible genes. In C3H mice this response is due to Type I IFN, is transient, and is clearly correlated with the subsequent infiltration of myeloid cells character¬istic of this arthritis. The ensuing synovial hyperproliferation in the infected tissue is also characteristic of human disease. Type I IFN is strongly associated with other inflammatory pathologies including Lupus and has been found in a subset of patients with Rheumatoid Arthritis. Intriguingly, this response is absent from mouse strains displaying mild arthritis, and the differential response can be studied in relevant cells from the joint tissue. Current analysis involves genetic and epigenetic regulation of the IFN locus, and the possible involvement of microRNAs in this response. A second model for chronic Lyme arthritis involves mice lacking the non-redundant inflammatory cytokine IL-10. In the absence of IL-10, arthritis is driven by a classic T cell dependent Type II IFN response to localized bacteria. Analysis of tissue infiltrate into the joint and use of cytokine reporter mice have revealed inflammatory cells responsible for arthritis regulation and for the development of arthritis in dysregulated situations. This model has many similarities to patients with chronic Lyme Disease.
We also utilize the mouse for the identi¬fication of the genetic elements that regulate the severity of Lyme arthritis. Epidemiological studies in humans support the existence of polymor¬phic genes that determine the severity of disease, and indicate that alleles of these genes may also set the stage for chronic conditions potentially involving autoimmune pathways. Intercross populations between mildly and severely arthritic strains of mice revealed multiple genetic loci (Quantitative Trait Loci or QTL) on five chromosomes of the mouse that regulate the severity of disease. The development of Interval Specific Congenic Lines of mice has allowed isolation of these loci and demonstration of associated penetrant arthritis phenotypes. Further delineation of the regions of interest through the development of recombinant congenics has led to the characterization of multiple sub-loci and reduced the associated intervals to 1-2Mbp. We are currently are poised to isolate invidual loci on unique recombinant congenic mouse lines and assessment of contribution to arthritis severity. Analysis of available SNP databases has allowed selection of several candidate genes. These are currently being assessed for effect on arthritis severity by a combination of cell biology experi¬mentation and by the development of allele-specific transgenic mice.
|Postdoctoral Fellowship||Harvard Medical School and Brigham and Women's Hospital
Medicine and Rheumatology & Immunology
|Doctoral Training||University of Minnesota
|Undergraduate||University of Kansas
- Whiteside SK, Snook JP, Ma Y, Sonderegger FL, Fisher C, Petersen C, Zachary JF, Round JL, Williams MA, Weis JJ (2018 Feb 15). IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis. J Immunol, 200(4), 1457-1470.
- Paquette JK, Ma Y, Fisher C, Li J, Lee SB, Zachary JF, Kim YS, Teuscher C, Weis JJ (2017 Nov 15). Genetic Control of Lyme Arthritis by Borrelia burgdorferi Arthritis-Associated Locus 1 Is Dependent on Localized Differential Production of IFN-beta and Requires Upregulation of Myostatin. J Immunol, 199(10), 3525-3534.
- Pioli PD, Whiteside SK, Weis JJ, Weis JH (2016 May). Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs. Immunobiology, 221(5), 618-33.
- Bramwell KK, Mock K, Ma Y, Weis JH, Teuscher C, Weis JJ (2015 Aug 15). beta-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 Secretion in Response to Inflammatory Stimuli. J Immunol, 195(4), 1647-56.
- Pioli PD, Chen X, Weis JJ, Weis JH (2015 May). Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3. Cell Immunol, 295(1), 1-18.
- Wee YS, Weis JJ, Gahring LC, Rogers SW, Weis JH (2015). Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins. PLoS ONE, 10(4), e0123218.
- Lochhead RB, Zachary JF, Dalla Rosa L, Ma Y, Weis JH, OConnell RM, Weis JJ (2015). Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis. PLoS ONE, 10(8), e0135142.
- Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ (2014 Dec 15). Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/BxN serum transfer arthritis through intrinsic control of type I IFN production. J Immunol, 193(12), 6050-60.
- Pioli PD, Debnath I, Weis JJ, Weis JH (2014 Sep 1). Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus. J Immunol, 193(5), 2546-53.
- Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, OConnell RM, Weis JJ (2014 Jun). MicroRNA-146a Provides Feedback Regulation of Lyme Arthritis but Not Carditis during Infection with Borrelia burgdorferi. PLoS Pathog, 10(6), e1004212.
- Donius LR, Weis JJ, Weis JH (2014 Jun). Murine complement receptor 1 is required for germinal center B cell maintenance but not initiation. Immunobiology, 219(6), 440-9.
- Bramwell KK, Ma Y, Weis JH, Chen X, Zachary JF, Teuscher C, Weis JJ (2014 Jan 2). Lysosomal beta-glucuronidase regulates Lyme and rheumatoid arthritis severity. J Clin Invest, 124(1), 311-20.
- Donius LR, Orlando CM, Weis JJ, Weis JH (2014 Jan). Generation of a novel Cr2 gene allele by homologous recombination that abrogates production of Cr2 but is sufficient for expression of Cr1. Immunobiology, 219(1), 53-63.
- Donius LR, Handy JM, Weis JJ, Weis JH (2013 Jul 1). Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1. J Immunol, 191(1), 434-47.
- Debnath I, Roundy KM, Pioli PD, Weis JJ, Weis JH (2013 Feb). Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins. Int Immunol, 25(2), 99-115.
- Pioli PD, Dahlem TJ, Weis JJ, Weis JH (2013). Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency. PLoS ONE, 8(7), e69216.
- Wee YS, Roundy KM, Weis JJ, Weis JH (2012 Dec). Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function. Innate Immun, 18(6), 834-45.
- Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ (2012 Sep 1). Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. J Immunol, 189(5), 2488-501.
- Dahlem T, Cho S, Spangrude GJ, Weis JJ, Weis JH (2012 Apr). Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation. Eur J Immunol, 42(4), 1038-43.
- Bramwell KK, Ma Y, Weis JH, Teuscher C, Weis JJ (2012 Mar). High-throughput genotyping of advanced congenic lines by high resolution melting analysis for identification of Bbaa2, a QTL controlling Lyme arthritis. Biotechniques, 52(3), 183-90.
- Sonderegger FL, Ma Y, Maylor-Hagan H, Brewster J, Huang X, Spangrude GJ, Zachary JF, Weis JH, Weis JJ (2012 Feb 1). Localized production of IL-10 suppresses early inflammatory cell infiltration and subsequent development of IFN-gamma-mediated Lyme arthritis. J Immunol, 188(3), 1381-93.
- Miller JC, Maylor-Hagen H, Ma Y, Weis JH, Weis JJ (2010 Jul). The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes. Infect Immun, 78(7), 3144-53.
- Roundy KM, Jacobson AC, Weis JJ, Weis JH (2010 Jan 13). The in vitro derivation of phenotypically mature and diverse B cells from immature spleen and bone marrow precursors. (Epub ahead of print) Eur J Immunol.
- Roundy KM, Weis JJ, Weis JH (2009 Dec). Deletion of putative intronic control sequences does not alter cell or stage specific expression of Cr2. Mol Immunol, 47(2-3), 517-25.
- Jacobson AC, Roundy KM, Weis JJ, Weis JH (2009 Sep 15). Regulation of murine splenic B cell CR3 expression by complement component 3. J Immunol, 183(6), 3963-70.
- Koening CL, Miller JC, Nelson JM, Ward DM, Kushner JP, Bockenstedt LK, Weis JJ, Kaplan J, De Domenico I (2009 Aug 27). Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi. Blood, 114(9), 1913-8.
- Ma Y, Miller JC, Crandall H, Larsen ET, Dunn DM, Weiss RB, Subramanian M, Weis JH, Zachary JF, Teuscher C, Weis JJ (2009 Aug). Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12. Infect Immun, 77(8), 3302-11.
- Jacobson AC, Weis JJ, Weis JH (2009 Apr). CD21 signaling via C3 regulates Purkinje cell protein 4 expression. Mol Immunol, 46(7), 1488-93.
- Miller JC, Ma Y, Bian J, Sheehan KC, Zachary JF, Weis JH, Schreiber RD, Weis JJ (2008 Dec 15). A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice. J Immunol, 181(12), 8492-503.
- Debnath I, Roundy KM, Dunn DM, Weiss RB, Weis JJ, Weis JH (2008 Dec). Defining a transcriptional fingerprint of murine splenic B-cell development. Genes Immun, 9(8), 706-20.
- Jacobson AC, Weis JJ, Weis JH (2008 Apr 1). Complement receptors 1 and 2 influence the immune environment in a B cell receptor-independent manner. J Immunol, 180(7), 5057-66.
- Rogers SW, Weis JJ, Ma Y, Teuscher C, Gahring LC (2008). Mouse chromosome 11 harbors genetic determinants of hippocampal strain-specific nicotinic receptor expression. Hippocampus, 18(8), 750-7.
- Wang X, Ma Y, Yoder A, Crandall H, Zachary JF, Fujinami RS, Weis JH, Weis JJ (2008 Jan). T cell infiltration is associated with increased Lyme arthritis in TLR2-/- mice. FEMS Immunol Med Microbiol, 52(1), 124-33.
- Jacobson AC, Ma Y, Zachary JF, Weis JJ, Weis JH (2007 Apr). Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection. Infect Immun, 75(4), 2075-8.
- Debnath I, Roundy KM, Weis JJ, Weis JH (2007). Analysis of the regulatory role of BAFF in controlling the expression of CD21 and CD23. Mol Immunol, (44), 2388-99.
- Bolz DD, Sundsbak RS, Ma Y, Akira S, Weis JH, Schwan TG, Weis JJ (2006 Dec). Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp. Infect Immun, 74(12), 6750-60.
- Crandall H, Dunn DM, Ma Y, Wooten RM, Zachary JF, Weis JH, Weiss RB, Weis JJ (2006 Dec 1). Gene expression profiling reveals unique pathways associated with differential severity of lyme arthritis. J Immunol, 177(11), 7930-42.
- Hale JS, Dahlem TJ, Margraf RL, Debnath I, Weis JJ, Weis JH (2006 Aug). Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin). J Leukoc Biol, 80(2), 383-98.
- Smith RA, Young J, Weis JJ, Weis JH (2006 Mar). Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes. Genes Immun, 7(2), 113-21.
- Stewart, PE, Wang, X, Bueschel DM, Clifton DR, Grimm, D, Tilly, K, Carroll JA, Weis JJ, Rosa PA (2006). Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian host. Infect Immun, (74), 3547-3553.
- Hojgaard A, Close R, Dunn DM, Weiss RB, Weis JJ, Weis JH (2006). Altered localization of CXCL13 expressing cells in mice deficient in Pactolus following an inflammatory stimulus. Immunology, (119), 212-23.
- Roundy KM, Spangrude G, Weis JJ, Weis JH (2005 Nov). Partial rescue of B cells in microphthalmic osteopetrotic marrow by loss of response to type I IFNs. Int Immunol, 17(11), 1495-503.
- Crandall H, Ma Y, Dunn DM, Sundsbak RS, Zachary JF, Olofsson P, Holmdahl R, Weis JH, Weiss RB, Teuscher C, Weis JJ (2005 Sep). Bb2Bb3 Regulation of Murine Lyme Arthritis Is Distinct from Ncf1 and Independent of the Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase. Am J Pathol, 167(3), 775-85.
- Wang X, Ma Y, Weis JH, Zachary JF, Kirschning CJ, Weis JJ (2005 Jan). Relative contributions of innate and acquired host responses to bacterial control and arthritis development in Lyme disease. Infect Immun, 73(1), 657-60.
- Bolz DD, Sundsbak RS, Ma Y, Akira S, Kirschning CJ, Zachary JF, Weis JH, Weis JJ (2004 Aug 1). MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. J Immunol, 173(3), 2003-10.
- Ferguson JS, Weis JJ, Martin JL, Schlesinger LS (2004 May). Complement protein C3 binding to Mycobacterium tuberculosis is initiated by the classical pathway in human bronchoalveolar lavage fluid. Infect Immun, 72(5), 2564-73.
- Wang G, Ma Y, Buyuk A, McClain S, Weis JJ, Schwartz I (2004 Feb 16). Impaired host defense to infection and Toll-like receptor 2-independent killing of Borrelia burgdorferi clinical isolates in TLR2-deficient C3H/HeJ mice. FEMS Microbiol Lett, 231(2), 219-25.
- Lawrenz MB, Wooten RM, Zachary JF, Drouin SM, Weis JJ, Wetsel RA, Norris SJ (2003 Aug). Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice. Infect Immun, 71(8), 4432-40.
- Yoder A, Wang X, Ma Y, Philipp MT, Heilbrun M, Weis JH, Kirschning CJ, Wooten RM, Weis JJ (2003 Jul). Tripalmitoyl-S-glyceryl-cysteine-dependent OspA vaccination of toll-like receptor 2-deficient mice results in effective protection from Borrelia burgdorferi challenge. Infect Immun, 71(7), 3894-900.
- Roundy K, Smith R, Weis JJ, Weis JH (2003 Feb). Overexpression of RANKL implicates IFN-beta-mediated elimination of B-cell precursors in the osteopetrotic bone of microphthalmic mice. J Bone Miner Res, 18(2), 278-88.
- Zabel MD, Wheeler W, Weis JJ, Weis JH (2002 Apr 1). Yin Yang 1, Oct1, and NFAT-4 form repeating, cyclosporin-sensitive regulatory modules within the murine CD21 intronic control region. J Immunol, 168(7), 3341-50.
- Potter MR, Rittling SR, Denhardt DT, Roper RJ, Weis JH, Teuscher C, Weis JJ (2002 Mar). Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi. Infect Immun, 70(3), 1372-81.
- Chakravarty L, Zabel MD, Weis JJ, Weis JH (2002 Feb). Depletion of Lyn kinase from the BCR complex and inhibition of B cell activation by excess CD21 ligation. Int Immunol, 14(2), 139-46.
- Wooten RM, Ma Y, Yoder RA, Brown JP, Weis JH, Zachary JF, Kirschning CJ, Weis JJ (2002 Jan 1). Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J Immunol, 168(1), 348-55.
- Roper RJ, Weis JJ, McCracken BA, Green CB, Ma Y, Weber KS, Fairbairn D, Butterfield RJ, Potter MR, Zachary JF, Doerge RW, Teuscher C (2001 Nov). Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun, 2(7), 388-97.
- Garrison S, Hojgaard A, Patillo D, Weis JJ, Weis JH (2001 Sep 21). Functional characterization of Pactolus, a beta-integrin-like protein preferentially expressed by neutrophils. J Biol Chem, 276(38), 35500-11.
- Brown EL, Wooten RM, Johnson BJ, Iozzo RV, Smith A, Dolan MC, Guo BP, Weis JJ, Hook M (2001 Apr). Resistance to Lyme disease in decorin-deficient mice. J Clin Invest, 107(7), 845-52.
- Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, Qureshi N, Michalek SM, Vogel SN (2001 Mar). Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun, 69(3), 1477-82.
- Zabel MD, Byrne BL, Weis JJ, Weis JH (2000 Oct 15). Cell-specific expression of the murine CD21 gene depends on accessibility of promoter and intronic elements. J Immunol, 165(8), 4437-45.
- Potter MR, Noben-Trauth N, Weis JH, Teuscher C, Weis JJ (2000 Oct). Interleukin-4 (IL-4) and IL-13 signaling pathways do not regulate Borrelia burgdorferi-induced arthritis in mice: IgG1 is not required for host control of tissue spirochetes. Infect Immun, 68(10), 5603-9.
- Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ (2000 Jul 15). Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J Immunol, 165(2), 618-22.
- Roundy K, Kollhoff A, Eichwald EJ, Weis JJ, Weis JH (1999 Dec 15). Microphthalmic mice display a B cell deficiency similar to that seen for mast and NK cells. J Immunol, 163(12), 6671-8.
- Margraf RL, Chen Y, Garrison S, Weis JJ, Weis JH (1999 Nov). Genomic organization, chromosomal localization, and transcriptional variants of the murine Pactolus gene. Mamm Genome, 10(11), 1075-81.
- Brown JP, Zachary JF, Teuscher C, Weis JJ, Wooten RM (1999 Oct). Dual role of interleukin-10 in murine Lyme disease: regulation of arthritis severity and host defense. Infect Immun, 67(10), 5142-50.
- Zabel MD, Weis JJ, Weis JH (1999 Sep 1). Lymphoid transcription of the murine CD21 gene is positively regulated by histone acetylation. J Immunol, 163(5), 2697-703.
- Hirschfeld M, Kirschning CJ, Schwandner R, Wesche H, Weis JH, Wooten RM, Weis JJ (1999 Sep 1). Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol, 163(5), 2382-6.
- Morrison TB, Ma Y, Weis JH, Weis JJ (1999 Apr). Rapid and sensitive quantification of Borrelia burgdorferi-infected mouse tissues by continuous fluorescent monitoring of PCR. J Clin Microbiol, 37(4), 987-92.
- Weis JJ, McCracken BA, Ma Y, Fairbairn D, Roper RJ, Morrison TB, Weis JH, Zachary JF, Doerge RW, Teuscher C (1999 Jan 15). Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J Immunol, 162(2), 948-56.
- Seiler KP, Ma Y, Weis JH, Frenette PS, Hynes RO, Wagner DD, Weis JJ (1998 Sep). E and P selectins are not required for resistance to severe murine lyme arthritis. Infect Immun, 66(9), 4557-9.
- Wooten RM, Morrison TB, Weis JH, Wright SD, Thieringer R, Weis JJ (1998 Jun 1). The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi. J Immunol, 160(11), 5485-92.
- Morrison TB, Weis JJ, Wittwer CT (1998 Jun). Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification. Biotechniques, 24(6), 954-8, 960, 962.
- Chen Y, Garrison S, Weis JJ, Weis JH (1998 Apr 10). Identification of pactolus, an integrin beta subunit-like cell-surface protein preferentially expressed by cells of the bone marrow. J Biol Chem, 273(15), 8711-8.
- Ma Y, Seiler KP, Eichwald EJ, Weis JH, Teuscher C, Weis JJ (1998 Jan). Distinct characteristics of resistance to Borrelia burgdorferi-induced arthritis in C57BL/6N mice. Infect Immun, 66(1), 161-8.
- Marietta EV, Weis JJ, Weis JH (1997 Sep 15). CD28 expression by mouse mast cells is modulated by lipopolysaccharide and outer surface protein A lipoprotein from Borrelia burgdorferi. J Immunol, 159(6), 2840-8.
- Weis JJ, Yang L, Seiler KP, Silver RM (1997 Jul). Pathological manifestations in murine Lyme disease: association with tissue invasion and spirochete persistence. Clin Infect Dis, 25 Suppl 1, S18-24.
- Morrison TB, Weis JH, Weis JJ (1997 May 15). Borrelia burgdorferi outer surface protein A (OspA) activates and primes human neutrophils. J Immunol, 158(10), 4838-45.
- Hu H, Martin BK, Weis JJ, Weis JH (1997 May 15). Expression of the murine CD21 gene is regulated by promoter and intronic sequences. J Immunol, 158(10), 4758-68.
- Wooten RM, Modur VR, McIntyre TM, Weis JJ (1996 Nov 15). Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-kappa B and inflammatory activation in human endothelial cells. J Immunol, 157(10), 4584-90.
- Mouritsen CL, Wittwer CT, Litwin CM, Yang L, Weis JJ, Martins TB, Jaskowski TD, Hill HR (1996 May). Polymerase chain reaction detection of Lyme disease: correlation with clinical manifestations and serologic responses. Am J Clin Pathol, 105(5), 647-54.
- Seiler KP, Vavrin Z, Eichwald E, Hibbs JB Jr, Weis JJ (1995 Oct). Nitric oxide production during murine Lyme disease: lack of involvement in host resistance or pathology. Infect Immun, 63(10), 3886-95.
- Silver RM, Yang L, Daynes RA, Branch DW, Salafia CM, Weis JJ (1995 Jan). Fetal outcome in murine Lyme disease. Infect Immun, 63(1), 66-72.
- Weis JJ, Ma Y, Erdile LF (1994 Oct). Biological activities of native and recombinant Borrelia burgdorferi outer surface protein A: dependence on lipid modification. Infect Immun, 62(10), 4632-6.
- Ma Y, Seiler KP, Tai KF, Yang L, Woods M, Weis JJ (1994 Sep). Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway. Infect Immun, 62(9), 3663-71.
- Yang L, Weis JH, Eichwald E, Kolbert CP, Persing DH, Weis JJ (1994 Feb). Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues. Infect Immun, 62(2), 492-500.
- Tai KF, Ma Y, Weis JJ (1994 Feb). Normal human B lymphocytes and mononuclear cells respond to the mitogenic and cytokine-stimulatory activities of Borrelia burgdorferi and its lipoprotein OspA. Infect Immun, 62(2), 520-8.
- Ma Y, Weis JJ (1993 Sep). Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties. Infect Immun, 61(9), 3843-53.
- Yang L, Ma Y, Schoenfeld R, Griffiths M, Eichwald E, Araneo B, Weis JJ (1992 Aug). Evidence for B-lymphocyte mitogen activity in Borrelia burgdorferi-infected mice. Infect Immun, 60(8), 3033-41.
- Schoenfeld R, Araneo B, Ma Y, Yang LM, Weis JJ (1992 Feb). Demonstration of a B-lymphocyte mitogen produced by the Lyme disease pathogen, Borrelia burgdorferi. Infect Immun, 60(2), 455-64.
- Yang LM, Behrens M, Weis JJ (1991 Oct 1). Identification of 5'-regions affecting the expression of the human CR2 gene. J Immunol, 147(7), 2404-10.
- Ma Y, Sturrock A, Weis JJ (1991 Feb). Intracellular localization of Borrelia burgdorferi within human endothelial cells. Infect Immun, 59(2), 671-8.
- Holguin MH, Kurtz CB, Parker CJ, Weis JJ, Weis JH (1990 Sep 15). Loss of human CR1- and murine Crry-like exons in human CR2 transcripts due to CR2 gene mutations. J Immunol, 145(6), 1776-81.
- Ribeiro JM, Weis JJ, Telford SR 3rd (1990 May). Saliva of the tick Ixodes dammini inhibits neutrophil function. Exp Parasitol, 70(4), 382-8.
- Kurtz CB, Paul MS, Aegerter M, Weis JJ, Weis JH (1989 Sep 15). Murine complement receptor gene family. II. Identification and characterization of the murine homolog (Cr2) to human CR2 and its molecular linkage to Crry. J Immunol, 143(6), 2058-67.
- Toothaker LE, Henjes AJ, Weis JJ (1989 May 15). Variability of CR2 gene products is due to alternative exon usage and different CR2 alleles. J Immunol, 142(10), 3668-75.
- Weis JJ, Toothaker LE, Smith JA, Weis JH, Fearon DT (1988 Mar 1). Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins. J Exp Med, 167(3), 1047-66.
- Weis JH, Morton CC, Bruns GA, Weis JJ, Klickstein LB, Wong WW, Fearon DT (1987 Jan 1). A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32. J Immunol, 138(1), 312-5.
- Tanner J, Weis J, Fearon D, Whang Y, Kieff E (1987). Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates absorption, capping, and endocytosis. Cell, 50, 203-212.
- Weis JJ, Richards SA, Smith JA, Fearon DT (1986 Aug 21). Purification of the B lymphocyte receptor for the C3d fragment of complement and the Epstein-Barr virus by monoclonal antibody affinity chromatography, and assessment of its functional capacities. J Immunol Methods, 92(1), 79-87.
- Weis JJ, Fearon DT, Klickstein LB, Wong WW, Richards SA, de Bruyn Kops A, Smith JA, Weis JH (1986 Aug). Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement. Proc Natl Acad Sci U S A, 83(15), 5639-43.
- Tedder TF, Weis JJ, Clement LT, Fearon DT, Cooper MD (1986 Jan). The role of receptors for complement in the induction of polyclonal B-cell proliferation and differentiation. J Clin Immunol, 6(1), 65-73.
- Weis JJ, Fearon DT (1985 Nov 5). The identification of N-linked oligosaccharides on the human CR2/Epstein-Barr virus receptor and their function in receptor metabolism, plasma membrane expression, and ligand binding. J Biol Chem, 260(25), 13824-30.
- Weis JJ, Law SK, Levine RP, Cleary PP (1985 Jan). Resistance to phagocytosis by group A streptococci: failure of deposited complement opsonins to interact with cellular receptors. J Immunol, 134(1), 500-5.
- Fingeroth JD, Weis JJ, Tedder TF, Strominger JL, Biro PA, Fearon DT (1984 Jul). Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci U S A, 81(14), 4510-4.
- Weis JJ, Tedder TF, Fearon DT (1984 Feb). Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes. Proc Natl Acad Sci U S A, 81(3), 881-5.
- Weis JJ, Kim Y, Cleary PP (1981). Restricted deposition of C3 on M+ Group A streptococci: correlation with resistance to phagocytosis. J Immunol, 128, 1897-1902.
- Whiteside SK, Snook JP, Williams MA, Weis JJ (2018 Dec). Bystander T Cells: A Balancing Act of Friends and Foes. [Review]. Trends Immunol, 39(12), 1021-1035.
- Bramwell KK, Teuscher C, Weis JJ (2014). Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity. [Review]. Front Cell Infect Microbiol, 4, 76.
- Miller JC, Ma Y, Crandall H, Wang X, Weis JJ (2008 Aug). Gene expression profiling provides insights into the pathways involved in inflammatory arthritis development: murine model of Lyme disease. [Review]. Exp Mol Pathol, 85(1), 20-7.
- Bolz DD, Weis JJ (2004 Aug). Molecular mimicry to Borrelia burgdorferi: pathway to autoimmunity? [Review]. Autoimmunity, 37(5), 387-92.
- Wooten RM, Ma Y, Yoder RA, Brown JP, Weis JH, Zachary JF, Kirschning CJ, Weis JJ (2003). Toll-like receptor 2 plays a pivotal role in host defense and inflammatory response to Borrelia burgdorferi. [Review]. Vector Borne Zoonotic Dis, 2, 217-220.
- Weis JJ (2002 Jul). Host-pathogen interactions and the pathogenesis of murine Lyme disease. [Review]. Curr Opin Rheumatol, 14(4), 399-403.
- Wooten RM, Weis JJ (2001 Jun). Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes. [Review]. Curr Opin Microbiol, 4(3), 274-9.
- Seiler KP, Weis JJ (1996 Aug). Immunity to Lyme disease: protection, pathology and persistence. [Review]. Curr Opin Immunol, 8(4), 503-9.
- Tedder TF, Clement LT, Weis JJ, Fearon DT, Cooper MD (1986). The C3d receptor identified by the HB-5 monoclonal antibody: expression and role as a receptor for Epstein-Barr virus. In Reinherz EL, Haynes BF, Nadler LM, Bernstein ID (Eds.), Leukocyte Type II. Vol 2: Human B Lymphocytes (pp. 499-508). New York: Springer-Verlag.
- Weis JJ, Fearon DT (1985). Demonstration of receptor function of membrane proteins by selection and immobilization with monoclonal antibodies. In Springer T (Ed.), Hybridomas in Biotechnology and Medicine (pp. 207-221). New York: Plenum Publ. Corp.
- Fearon DT, Klickstein LB, Wong WW, Wilson JG, Moore FD, Weis JJ, Weis JH, Jack RM, Carter RH, Ahearn JM (1989). Immunoregulatory Functions of Complement: Structural and Functional Studies of Complement Receptor type 1 (CR1;CD35) and type 2 (CR2;CD21). Biochemistry of the Acute Allergic Reactions: Fifth International Symposium, 211-220.