Dean Tantin, PhD
- Gene Regulation
- Development and Regulation of Immune Responses
- Stem Cells
- Transcriptional Control of Malignant State
- Departments: Pathology - Associate Professor
- Divisions: Microbiology and Immunology
- Cancer Center Programs: Nuclear Control of Cell Growth & Differentiation
Academic Office Information
Emma Eccles Jones Research Building
15 North Medical Drive East, Room: 5200K
Salt Lake City, UT 84112
Dean Tantin is an Associate Professor in the Department of Pathology at the University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute.
Tantin studies gene expression and its relationship to immune and stem cell function, and malignancy. He focuses on a class of transcription factors that have been tied to cellular reprogramming and immune function. The proteins are called Oct1, Oct2, and Oct4. These proteins affect cellular physiology and differentiation state through control of metabolism and through control of poised (silent but readily inducible) gene expression states. They interact with multiple cofactors that control local chromatin and gene expression.
Tantin received a B.S. in Molecular Biology from the University of California, San Diego and a Ph.D. from the UCLA Molecular Biology Interdepartmental Ph.D. program. He was a Postdoctoral Fellow at the Massachusetts Institute of Technology Center for Cancer Reseach and Department of Biology under Nobel Laureate Phil Sharp.
|Postdoctoral Fellowship||Massachusetts Institute of Technology Center for Cancer Research
|Postdoctoral Training||Massachusetts Institute of Technology Center for Cancer Research
|Postdoctoral Fellowship||Massachusetts Institute of Technology, Center for Cancer Research
|Doctoral Training||University of California, Los Angeles, Molecular Biology Institute Interdepartmental Ph.D. Program
|Undergraduate||University of California, San Diego Division of Biology
- Jafek JL, Shakya A, Tai PY, Ibarra A, Kim H, Maddox J, Chumley J, Spangrude GJ, Miles RR, Kelley TW, Tantin D (2019). Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia. Exp Hematol, 76, 38-48.e2.
- Kim H, Dickey L, Stone C, Jafek JL, Lane TE, Tantin D (2019). T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response. J Neuroinflammation, 16(1), 133.
- Vzquez-Arregun K, Bensard C, Schell JC, Swanson E, Chen X, Rutter J, Tantin D (2019). Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy. PLoS Genet, 15(5), e1007687.
- Shen Z, Formosa T, Tantin D (2018). FACT Inhibition Blocks Induction But Not Maintenance of Pluripotency. Stem Cells Dev, 27(24), 1693-1701.
- Vazquez-Arreguin K, Maddox J, Kang J, Park D, Cano RR, Factor RE, Ludwig T, Tantin D (2018). BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism. Mol Cancer Res, 16(3), 439-452.
- Shen Z, Kang J, Shakya A, Tabaka M, Jarboe EA, Regev A, Tantin D (2017). Enforcement of developmental lineage specificity by transcription factor Oct1. eLife, pii: e20937.
- Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J (2016). Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. eLife, pii: e17985.
- Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA, Tantin D (2015). Oct1 and OCA-B are selectively required for CD4 memory T cell function. J Exp Med, 212(12), 2115-31.
- Shakya A, Callister C, Goren A, Yosef N, Garg N, Khoddami V, Nix D, Regev A, Tantin D (2015). Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion. Mol Cell Biol, 35(6), 1014-25.
- Manning J, Mitchell B, Appadurai DA, Shakya A, Pierce LJ, Wang H, Nganga V, Swanson PC, May JM, Tantin D, Spangrude GJ (2013). Vitamin C promotes maturation of T-cells. Antioxid Redox Signal, 19(17), 2054-67.
- Kang J, Shen Z, Lim JM, Handa H, Wells L, Tantin D (2013). Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation. FASEB J, 27(7), 2807-17.
- Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A (2013). Dynamic regulatory network controlling TH17 cell differentiation. Nature, 496(7446), 461-8.
- Li Q, Shakya A, Guo X, Zhang H, Tantin D, Jensen PE, Chen X (2012). Constitutive nuclear localization of NFAT in Foxp3+ regulatory T cells independent of calcineurin activity. J Immunol, 188(9), 4268-77.
- Maddox J, Shakya A, South S, Shelton D, Andersen JN, Chidester S, Kang J, Gligorich KM, Jones DA, Spangrude GJ, Welm BE, Tantin D (2012). Transcription factor Oct1 is a somatic and cancer stem cell determinant. PLoS Genet, 8(11), e1003048.
- Ferraris L, Stewart AP, Kang J, DeSimone AM, Gemberling M, Tantin D, Fairbrother WG (2011). Combinatorial binding of transcription factors in the pluripotency control regions of the genome. Genome Res, 21(7), 1055-64.
- Shakya A, Kang J, Chumley J, Williams MA, Tantin D (2011). Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. J Biol Chem, 286(1), 450-9.
- Kang J, Goodman B, Zheng Y, Tantin D (2011). Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination. PLoS ONE, 6(8), e23872.
- Kiesler P, Shakya A, Tantin D, Vercelli D (2009). An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression. Hum Mol Genet, 18(23), 4513-20.
- Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D (2009). Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol, 11(3), 320-7.
- Kang J, Gemberling M, Nakamura M, Whitby FG, Handa H, Fairbrother WG, Tantin D (2009). A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev, 23(2), 208-22.
- Vazquez-Arreguin K, Tantin D (2016). The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks. [Review]. Biochim Biophys Acta, 1859(6), 792-804.
- Tantin D (2013). Oct transcription factors in development and stem cells: insights and mechanisms. [Review]. Development, 140(14), 2857-66.
- Tantin D, Voth WP, Shakya A (2013). Efficient chromatin immunoprecipitation using limiting amounts of biomass. [Review]. J Vis Exp, (75), e50064.
- Kang J, Shakya A, Tantin D (2009). Stem cells, stress, metabolism and cancer: a drama in two Octs. [Review]. Trends Biochem Sci, 34(10), 491-9.
- Maddox, J, Tantin, D (2013). Oct4, Oct1 and Cancer Stem Cells. In Cancer Stem Cells. Hoboken, NJ, U.S.A.: Wiley & Sons.