Tracey J. Lamb, PhD

Research Interests

  • Malaria Immunopathogenesis


Lab Website


  • English

Academic Information

  • Departments: Pathology - Associate Professor
  • Divisions: Microbiology and Immunology

Academic Office Information

  • 801-213-2097
  • Emma Eccles Jones Medical Research Building
    Pathology Department
    15 N Medical Dr E, Room: 4280B
    Salt Lake City, UT


Global Impact


Description Country
Lamb TJ. IL-10 protects against the pathogenesis of malaria infection in mice. University of East London, London, England, United Kingdom United Kingdom
Lamb TJ. Can EBV contribute to the severity of malaria infections? Trinity College, Dublin, Dublin, Ireland Ireland
Lamb TJ. Can EBV contribute to the severity of malaria infections? Norwegian University of Science and Technology, Trondheim, Norway Norway
Lamb TJ. EphA2 mediates breakdown of the blood brain barrier in cerebral malaria, Chantal Biya International Research Center, Yaounde, Cameroon. Cameroon

Selected Publications

Journal Article

  1. Lin J, Sondekamp J, Cunningham D, Deroost K, Tshitenge T, McLaughlin S, Lamb T, Spencer-Dean B, Hosking C, Ramesar J, Janse C, Graham C, OGarra A, Langhorne J (2017). Signatures of malaria-associated pathology revealed by high-resolution whole blood transcriptomicsin a rodent model of malaria. Sci Rep, 7, 41722.
  2. Hudson LE, Stewart TP, Fasken MB, Corbett AH, Lamb TJ (2016). Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice. J Vis Exp, (108), e53453.
  3. Hudson LE, McDermott CD, Stewart TP, Hudson WH, Rios D, Fasken MB, Corbett AH, Lamb TJ (2016). Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System. PLoS One, 11(4), e0153351.
  4. Joyner C, Moreno A, Meyer EV, Cabrera-Mora M, MaHPIC Consortium, Kissinger JC, Barnwell JW, Galinski MR (2016). Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infections. Malar J, 15(1), 451.
  5. Mimche PN, Brady LM, Bray CF, Lee CM, Thapa M, King TP, Quicke K, McDermott CD, Mimche SM, Grakoui A, Morgan ET, Lamb TJ (2015). The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. Hepatology, 62(3), 900-14.
  6. Matar CG, Anthony NR, OFlaherty BM, Jacobs NT, Priyamvada L, Engwerda CR, Speck SH, Lamb TJ (2015). Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. PLoS Pathog, 11(5), e1004858.
  7. Mimche PN, Brady LM, Keeton S, Fenne DS, King TP, Quicke KM, Hudson LE, Lamb TJ (2015). Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation. PLoS One, 10(9), e0138835.
  8. Hudson LE, Fasken MB, McDermott CD, McBride SM, Kuiper EG, Guiliano DB, Corbett AH, Lamb TJ (2014). Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii. PLoS One, 9(11), e112660.
  9. Abanyie FA, McCracken C, Kirwan P, Molloy SF, Asaolu SO, Holland CV, Gutman J, Lamb TJ (2013). Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children. Malar J, 12, 1.
  10. Freitas do Rosario AP, Lamb T, Spence P, Stephens R, Lang A, Roers A, Muller W, OGarra A, Langhorne J (2012). IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol, 188(3), 1178-90.
  11. Fairlie-Clarke KJ, Lamb TJ, Langhorne J, Graham AL, Allen JE (2010). Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity. BMC Immunol, 11, 6.
  12. Saunders A, Lamb T, Pascall J, Hutchings A, Dion C, Carter C, Hepburn L, Langhorne J, Butcher GW (2009). Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria. Malar J, 8, 53.
  13. Cadman ET, Abdallah AY, Voisine C, Sponaas AM, Corran P, Lamb T, Brown D, Ndungu F, Langhorne J (2008). Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity. Infect Immun, 76(9), 3924-31.
  14. Lamb TJ, Langhorne J (2008). The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites. Malar J, 7, 68.
  15. Lamb TJ, Harris A, Le Goff L, Read AF, Allen JE (2008). Litomosoides sigmodontis: vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection. Exp Parasitol, 118(2), 285-9.
  16. Lamb TJ, Voisine C, Koernig S, Egan CA, Harnett W, Langhorne J (2007). The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES-62. Parasite Immunol, 29(5), 271-6.
  17. Lamb TJ, Graham AL, Le Goff L, Allen JE (2005). Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered. Parasite Immunol, 27(9), 317-24.
  18. Graham AL, Taylor MD, Le Goff L, Lamb TJ, Magennis M, Allen JE (2005). Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis. Microbes Infect, 7(4), 612-8.
  19. Graham AL, Lamb TJ, Read AF, Allen JE (2005). Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency. J Infect Dis, 191(3), 410-21.
  20. Lamb TJ, Le Goff L, Kurniawan A, Guiliano DB, Fenn K, Blaxter ML, Read AF, Allen JE (2004). Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage. J Infect Dis, 189(1), 120-7.
  21. Le Goff L, Lamb TJ, Graham AL, Harcus Y, Allen JE (2002). IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. Int J Parasitol, 32(10), 1277-84.
  22. Djikeng A, Ferreira L, DAngelo M, Dolezal P, Lamb T, Murta S, Triggs V, Ulbert S, Villarino A, Renzi S, Ullu E, Tschudi C (2001). Characterization of a candidate Trypanosoma brucei U1 small nuclear RNA gene. Mol Biochem Parasitol, 113(1), 109-15.


  1. Hudson LE, Anderson SE, Corbett AH, Lamb TJ (2017). Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies. [Review]. Clin Microbiol Rev, 30(1), 191-231.
  2. King T, Lamb T (2015). Interferon-gamma: The Jekyll and Hyde of Malaria. [Review]. PLoS Pathog, 11(10), e1005118.
  3. Matar CG, Jacobs NT, Speck SH, Lamb TJ, Moormann AM (2015). Does EBV alter the pathogenesis of malaria? [Review]. Parasite Immunol, 37(9), 433-45.
  4. Stephens R, Culleton RL, Lamb TJ (2012). The contribution of Plasmodium chabaudi to our understanding of malaria. [Review]. Trends Parasitol, 28(2), 73-82.
  5. Lamb TJ, Schenk MP, Todryk SM (2010). How do malaria parasites activate dendritic cells? [Review]. Future Microbiol, 5(8), 1167-71.
  6. Fenton A, Lamb T, Graham AL (2008). Optimality analysis of Th1/Th2 immune responses during microparasite-macroparasite co-infection, with epidemiological feedbacks. [Review]. Parasitology, 135(7), 841-53.
  7. Lamb TJ, Graham AL, Petrie A (2008). T testing the immune system. [Review]. Immunity, 28(3), 288-92.
  8. Lamb TJ, Brown DE, Potocnik AJ, Langhorne J (2006). Insights into the immunopathogenesis of malaria using mouse models. [Review]. Expert Rev Mol Med, 8(6), 1-22.