Allie Harris Grossmann

Allie Harris Grossmann, MD, PhD

Languages spoken: English

Academic Information

Departments Adjunct - Pathology , Adjunct - Oncological Sciences

Lab

Board Certification

  • American Board of Pathology (Anatomic)
  • American Board of Pathology (Sub: Molecular Genetic Pathology)

Education History

Undergraduate College of Idaho
 BS
Professional Medical Oregon Health Sciences University
 MD, PhD
Residency University of Utah, ARUP Laboratories
 Resident
Research Fellow University of Utah
 Research Fellow
Fellowship University of Utah, Department of Pathology, ARUP Laboratories
 Clinical Fellow

Selected Publications

Journal Article

  1. Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle M (2014). Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Molecular biology of the cell, 25(18), 2695-709.
  2. Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A, Ashley T, Liskay R (1996). Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nature genetics, 13(3), 336-42.
  3. Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A, Liskay R (1998). Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nature genetics, 18(3), 276-9.
  4. Baker SM, Harris AC, Tsao JL, Flath TJ, Bronner CE, Gordon M, Shibata D, Liskay R (1998). Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer research, 58(6), 1087-9.
  5. Yoo JH, Brady SW, Acosta-Alvarez L, Rogers A, Peng J, Sorensen LK, Wolff RK, Mleynek T, Shin D, Rich CP, Kircher DA, Bild A, Odelberg SJ, Li DY, Holmen SL, Grossmann A (2019). The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State. Cancer research, 79(11), 2892-2908.
  6. Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li D (2015). Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation. Circulation, 131(3), 289-299.
  7. Grossmann AH, Kolibaba KS, Willis SG, Corbin AS, Langdon WS, Deininger MW, Druker B (2004). Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. FEBS letters, 577(3), 555-62.
  8. Gurtu VE, Verma S, Grossmann AH, Liskay RM, Skarnes WC, Baker S (2002). Maternal effect for DNA mismatch repair in the mouse. Genetics, 160(1), 271-7.
  9. Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li D (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. The Journal of clinical investigation, 121(5), 1871-81.
  10. Barrott JJ, Illum BE, Jin H, Hedberg ML, Wang Y, Grossmann A, Haldar M, Capecchi MR, Jones KB (2018). Paracrine osteoprotegerin and ß-catenin stabilization support synovial sarcomagenesis in periosteal cells. The Journal of clinical investigation, 28(1), 207-18.
  11. Sant DW, Margraf RL, Stevenson DA, Grossmann AH, Viskochil DH, Hanson H, Everitt MD, Rios JJ, Elefteriou F, Hennessey T, Mao R (2015). Evaluation of somatic mutations in tibial pseudarthrosis samples in neurofibromatosis type 1. Journal of medical genetics, 52(4), 256-61.
  12. Zhu W, London NR, Gibson CC, Davis CT, Tong Z, Sorensen LK, Shi DS, Guo J, Smith MC, Grossmann AH, Thomas KR, Li D (2012). Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability. Nature, 492(7428), 252-5.
  13. Yang H, Kircher DA, Kim KH, Grossmann AH, VanBrocklin MW, Holmen SL, Robinson J (2017). Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma. Oncogene, 36(27), 3842-3851.
  14. Hall BJ, Grossmann AH, Webber NP, Ward RA, Tripp SR, Rosenthal HG, Florell SR, Randall RL, Cockerell CJ, Layfield LJ, Liu (2013). Atypical intradermal smooth muscle neoplasms (formerly cutaneous leiomyosarcomas): case series, immunohistochemical profile and review of the literature. Applied immunohistochemistry & molecular morphology, 21(2), 132-8.
  15. Abel HJ, Al-Kateb H, Cottrell CE, Bredemeyer AJ, Pritchard CC, Grossmann AH, Wallander ML, Pfeifer JD, Lockwood CM, Duncavage E (2014). Detection of gene rearrangements in targeted clinical next-generation sequencing. The Journal of molecular diagnostics, 16(4), 405-17.
  16. Goodwin ML, Huifeng J, Smith-Frye K, Zhu JF, Monument MJ, Grossmann A, Randall RL, Capecchi MR, Jones K (2014). Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment. Cancer cell, 26(6), 851-62.
  17. Yoo JH, Shi DS, Grossmann AH, Sorensen LK, Tong Z, Mleynek TM, Rogers A, Zhu W, Richards JR, Winter JM, Zhu J, Dunn C, Bajji A, Shenderovich M, Mueller AL, Woodman SE, Harbour JW, Thomas KR, Odelberg SJ, Ostanin K, Li D (2016). ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma. Cancer cell, 29(6), 889-904.
  18. Kircher DA, Trombetti KA, Silvis MR, Parkman GL, Fischer GM, Angel SN, Stehn CM, Strain SC, Grossmann AH, Duffy KL, Boucher KM, McMahon M, Davies MA, Mendoza MC, VanBrocklin MW, Holmen S (2019). AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis. Molecular cancer research, 17(9), 1787-1800.
  19. Grossmann AH, Layfield LJ, Randall R (2012). Classification, molecular characterization, and the significance of pten alteration in leiomyosarcoma. Sarcoma, 2012, 380896.
  20. Grossmann AH, Yoo JH, Clancy J, Sorensen LK, Sedgwick A, Tong Z, Ostanin K, Rogers A, Grossmann KF, Tripp SR, Thomas KR, D'Souza-Schorey C, Odelberg SJ, Li D (2013). The small GTPase ARF6 stimulates ß-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis. Science signaling, 6(265), ra14.
  21. Shin CH, Grossmann AH, Holmen SL, Robinson J (2015). The BRAF kinase domain promotes the development of gliomas in vivo. Genes & cancer, 6(1-2), 9-18.
  22. Barrott JJ, Illum BE, Jin H, Zhu JF, Mosbruger T, Monument MJ, Smith-Fry K, Cable MG, Wang Y, Grossmann AH, Capecchi MR, Jones K (2015). ß-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition. Oncotarget, 6(26), 22758-66.
  23. Li J, Mulvihill TS, Li L, Barrott JJ, Nelson ML, Wagner L, Lock IC, Pozner A, Lambert SL, Ozenberger BB, Ward MB, Grossmann AH, Liu T, Banito A, Cairns BR, Jones K (2021). A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction. Cancer discovery, 11(10), 2620-2637.
  24. Cho JH, Robinson JP, Arave RA, Burnett WJ, Kircher DA, Chen G, Davies MA, Grossmann AH, VanBrocklin MW, McMahon M, Holmen S (2015). AKT1 Activation Promotes Development of Melanoma Metastases. Cell reports, 13(5), 898-905.
  25. Ekiz HA, Huffaker TB, Grossmann AH, Stephens WZ, Williams MA, Round JL, O'Connell R (2019). MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers. JCI insight, 4(6),
  26. Trivedi S, Grossmann AH, Jensen O, Cody MJ, Wahlig TA, Hayakawa Serpa P, Langelier C, Warren KJ, Yost CC, Leung D (2021). Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection. Open forum infectious diseases, 8(6), ofab237.
  27. Sun Z, Zhao H, Fang D, Davis CT, Shi DS, Lei K, Rich BE, Winter JM, Guo L, Sorensen LK, Pryor RJ, Zhu N, Lu S, Dickey LL, Doty DJ, Tong Z, Thomas KR, Mueller AL, Grossmann AH, Zhang B, Lane TE, Fujinami RS, Odelberg SJ, Zhu (2022). Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling. Neuron, 110(19), 3106-3120.e7.
  28. Richards JR, Shin D, Pryor R, Sorensen LK, Sun Z, So WM, Park G, Wolff R, Truong A, McMahon M, Grossmann AH, Harbour JW, Zhu W, Odelberg SJ, Yoo JH (2023). Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis. Oncogene, 42(35), 2629-40.
  29. Wee, Y., Wang, J., Wilson, E.C., Rich, C.P., Rogers, A., Tong, Z, DeGroot, E., Gopal, V., Davies, M.A., Ekiz, H.A., Tay, J.K.H., Stubben, C., Holmen, S.L., Wolff, R.K., Grossmann, A.H (2024). Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy. Nature communications, 15(1), 6613.

Review

  1. Grossmann AH, Samowitz WS (2011). Epidermal growth factor receptor pathway mutations and colorectal cancer therapy. [Review]. Arch Pathol Lab Med, 135, (10), 1278-82.
  2. Grossmann AH, Grossmann KF, Wallander M (2012). Molecular testing in malignant melanoma. Diagnostic cytopathology, 40(6), 503-10.
  3. Grossmann AH, Zhao H, Jenkins N, Zhu W, Richards JR, Yoo JH, Winter JM, Rich B, Mleynek TM, Li DY, Odelberg S (2016). The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease. Small GTPases, 10(1), 1-12.

Book Chapter

  1. Liu T, Narra KK, Stephenson PD, Grossmann AH, Downs-Kelly EP, Albertson (2016). Pathology of Soft Tissue Tumors.

Case Report

  1. Anker CJ, Ribas A, Grossmann AH, Chen X, Narra KK, Akerley W, Andtbacka RH, Noyes RD, Shrieve DC, Grossmann K (2013). Severe liver and skin toxicity after radiation and vemurafenib in metastatic melanoma. Journal of clinical oncology, 31(17), e283-7.
  2. Monument MJ, Grossmann AH, Baker CC, Randall RL, Liu T, Albertson D (2015). Molecular Confirmation of Ewing Sarcoma in an 85-Year-Old Woman. International journal of surgical pathology, 23(6), 500-504.

Editorial

  1. Grossmann AH, Samowitz W, Cohen M (2014). Dance Well: Partnering with reference laboratories for oncology testing. Arch Pathol Lab Med, 139(5), 585-586.