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Allie Grossmann Lab

Dr. Grossmann in front of microscope
Cells on glass slide

Our laboratory focuses on understanding mechanisms of cancer progression and developing clinical interventions. Our goals are to 1) uncover novel mechanisms of tumorigenesis and metastasis, 2) identify biomarkers that prognosticate disease progression or predict treatment response and 3) collaborate with industry to develop new therapies for the prevention and treatment of cancer progression.


Our work in melanoma integrates current knowledge of genomic drivers with studies of the small GTPase ARF6, which controls critical cellular functions such as vesicular trafficking, cytoskeletal rearrangements, cell-cell adhesive interactions, motility, invadopodia, tumor microvesicle shedding and exosome generation. Through our studies of ARF6, we hope to illuminate how small GTPases potentiate signaling from classic oncogenic pathways such as WNT/b-catenin, RAS, BRAF/MAPK, and PI3K/AKT. In addition, we are probing the role of ARF6 in the tumor inflammatory microenvironment, as ARF6 is known to be critical for inflammatory cytokine signaling leading to vascular leak, edema, and end-organ damage in sepsis, arthritis, and retinopathy. Tumor-intrinsic inflammatory signaling has been linked to cancer progression and may represent a mechanism by which ARF6 promotes tumor growth, invasion, metastasis and perhaps tumor immune evasion.

We use a variety of in vitro and in vivo approaches to study cancer progression, including genetically-engineered mouse models, xenografts, cell culture, microscopy, biochemical, molecular biological, and genomic approaches. With clinical expertise in Anatomic and Molecular Pathology, trainees have access to mentored skill development by Dr. Grossmann in gross and microscopic morphologic assessment of in vivo tumor model systems.

View our recent article about melanoma spreading without tumor growth



Allie Harris Grossmann, MD, PhD

Assistant Professor
Division of Anatomic Pathology
Department of Pathology
University of Utah

Office Phone: (801) 213-4217
Email Address:

Specialties: Melanoma and Cutaneous Oncology, Molecular Genetic Pathology, Pathology, Anatomical

Fellowship: University of Utah, Department of Pathology, ARUP Laboratories

Residency: University of Utah, ARUP Laboratories

Medical School: Oregon Health Sciences University

Roger Wolff, PhD

Senior Scientist, Lab Director

Coulson Rich

Lab Technician

Yinshen Wee

Postdoctoral Research Associate

Junhua Wang

Graduate Research Assistant