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Mariana Mandi Gandelman

Mariana Mandi Gandelman, MSci, PhD

Languages spoken: English, Portuguese, Spanish

Academic Information

Departments Primary - Neurology

Academic Office Information

mgandelman@genetics.utah.edu

Education History

Postdoctoral Training University of Utah
Postdoctoral Training
Universidad de la Republica
PHD
Post Graduate Training Universidad de la Republica
MSci
Universidad de la Republica
SB

Selected Publications

Journal Article

  1. Levy MA, Tian J, Gandelman M, Cheng H, Tsapekos M, Crego SR, Maddela R, Sinnott R (2023). A Multivitamin Mixture Protects against Oxidative Stress-Mediated Telomere Shortening. J Diet Suppl, 21(1), 53-70. (Read full article)
  2. Figueroa KP, Anderson CJ, Paul S, Dansithong W, Gandelman M, Scoles DR, Pulst SM (2022). Slc9a6 mutation causes Purkinje cell loss and ataxia in the shaker rat. Hum Mol Genet, 32(10), 1647-1659. (Read full article)
  3. Paul S, Dansithong W, Gandelman M, Figueroa KP, Zu T, Ranum LPW, Scoles DR, Pulst SM (2022). Staufen Impairs Autophagy in Neurodegeneration. Ann Neurol, 93(2), 398-416. (Read full article)
  4. Scoles DR, Gandelman M, Paul S, Dexheimer T, Dansithong W, Figueroa KP, Pflieger LT, Redlin S, Kales SC, Sun H, Maloney D, Damoiseaux R, Henderson MJ, Simeonov A, Jadhav A, Pulst SM (2022). A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2. J Biol Chem, 298(8), 102228. (Read full article)
  5. Cendelin J, Cvetanovic M, Gandelman M, Hirai H, Orr HT, Pulst SM, Strupp M, Tichanek F, Tuma J, Manto M (2021). Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications. Cerebellum, 21(3), 452-481. (Read full article)
  6. Gandelman M, Dansithong W, Kales SC, Paul S, Maag G, Aoyama E, Zakharov A, Rai G, Dexheimer T, Whitehill BM, Sun H, Jadhav A, Simeonov A, Henderson MJ, Huynh DP, Pulst SM, Scoles DR (2021). The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy. J Biol Chem, 297(4), 101191. (Read full article)
  7. Paul S, Dansithong W, Figueroa KP, Gandelman M, Scoles DR, Pulst SM (2021). Staufen1 in Human Neurodegeneration. Ann Neurol, 89(6), 1114-1128. (Read full article)
  8. Gandelman M, Dansithong W, Figueroa KP, Paul S, Scoles DR, Pulst SM (2020). Staufen 1 amplifies proapoptotic activation of the unfolded protein response. Cell Death Differ, 27(10), 2942-2951. (Read full article)
  9. Scoles DR, Dansithong W, Pflieger LT, Paul S, Gandelman M, Figueroa KP, Rigo F, Bennett CF, Pulst SM (2020). ALS-associated genes in SCA2 mouse spinal cord transcriptomes. Hum Mol Genet, 29(10), 1658-1672. (Read full article)
  10. Gandelman M, Levy M, Cassina P, Barbeito L, Beckman JS (2013). P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway. J Neurochem, 126(3), 382-8. (Read full article)
  11. Miquel E, Cassina A, Martnez-Palma L, Bolatto C, Tras E, Gandelman M, Radi R, Barbeito L, Cassina P (2012). Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis. PLoS One, 7(4), e34776. (Read full article)
  12. Gandelman M, Peluffo H, Beckman JS, Cassina P, Barbeito L (2010). Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis. J Neuroinflammation, 7, 33. (Read full article)
  13. Cassina P, Cassina A, Pehar M, Castellanos R, Gandelman M, de Len A, Robinson KM, Mason RP, Beckman JS, Barbeito L, Radi R (2008). Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci, 28(16), 4115-22. (Read full article)
  14. Dupuis L, Pehar M, Cassina P, Rene F, Castellanos R, Rouaux C, Gandelman M, Dimou L, Schwab ME, Loeffler JP, Barbeito L, Gonzalez de Aguilar JL (2008). Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proc Natl Acad Sci U S A, 105(2), 740-5. (Read full article)

Other

  1. Gandelman M, Dansithong W, Figueroa KP, Paul S, Scoles DR, Pulst SM (2021). Correction: Staufen 1 amplifies proapoptotic activation of the unfolded protein response. Cell Death Differ (28(12), p. 3374). England. (Read full article)