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Pulst and Scoles Laboratories

PIONEERING ADULT-ONSET NEURODEGENERATION RESEARCH

Single neuron lit up in yellow and red against a black background

Pulst and Scoles Laboratories

PIONEERING ADULT-ONSET NEURODEGENERATION RESEARCH

GENETIC ANALYSIS OF HUMAN FAMILIES

Our laboratory studies usually begin with genetic analysis of human families, followed by modeling of the disease process by introducing the mutations found in the families into cells or mice. This group has been interested in amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD), and in the spinocerebellar ataxias, which are inherited, progressive, neurodegenerative diseases that affect the cerebellum (a part of the brain primarily concerned with coordination of movement). 

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Red neurons

HIGHLIGHTED PUBLICATIONS

Scan of human brain (blue and pink cells, SCA4)

A GGC-Repeat Expansion In ZFHX3 Encoding Polyglycine Causes Spinocerebellar Ataxia Type 4 and Impairs Autophagy 

Decorative

Antisense-Therapie Neurologischer Erkrankungen

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Staufen1 Links RNA Stress Granules and Autophagy in a Model of Neurodegeneration

New BAC SCA2 Model

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model

Antisense publication

Antisense Oligonucleotide Therapy for Spinocerebellar Ataxia Type 2

OUR TEAM

The Pulst and Scoles Lab is a talented group of individuals, each playing a key role in driving neurology research forward. We are united by a shared passion for scientific exploration and innovation.

Meet the Team

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