Tracey J. Lamb

Tracey J. Lamb, PhD

Languages spoken: English

Academic Information

Departments Primary - Pathology

Lab

Selected Publications

Journal Article

  1. Lamb TJ, Harris A, Le Goff L, Read AF, Allen J (2008). Litomosoides sigmodontis: vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection. Experimental parasitology, 118(2), 285-9. (Read full article)
  2. Mimche PN, Brady LM, Bray CF, Lee CM, Thapa M, King TP, Quicke K, McDermott CD, Mimche SM, Grakoui A, Morgan ET, Lamb T (2015). The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. Hepatology (Baltimore, Md.), 62(3), 900-14. (Read full article)
  3. Cadman ET, Abdallah AY, Voisine C, Sponaas AM, Corran P, Lamb T, Brown D, Ndungu F, Langhorne (2008). Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity. Infection and immunity, 76(9), 3924-31. (Read full article)
  4. Le Goff L, Lamb TJ, Graham AL, Harcus Y, Allen J (2002). IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. International journal for parasitology, 32(10), 1277-84. (Read full article)
  5. Freitas do Rosario AP, Lamb T, Spence P, Stephens R, Lang A, Roers A, Muller W, O'Garra A, Langhorne (2012). IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. Journal of immunology (Baltimore, Md., 188(3), 1178-90. (Read full article)
  6. Lamb TJ, Le Goff L, Kurniawan A, Guiliano DB, Fenn K, Blaxter ML, Read AF, Allen J (2004). Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage. The Journal of infectious diseases, 189(1), 120-7. (Read full article)
  7. Graham AL, Lamb TJ, Read AF, Allen J (2005). Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency. The Journal of infectious diseases, 191(3), 410-21. (Read full article)
  8. Djikeng A, Ferreira L, D'Angelo M, Dolezal P, Lamb T, Murta S, Triggs V, Ulbert S, Villarino A, Renzi S, Ullu E, Tschudi (2001). Characterization of a candidate Trypanosoma brucei U1 small nuclear RNA gene. Molecular and biochemical parasitology, 113(1), 109-15. (Read full article)
  9. Lamb TJ, Graham AL, Le Goff L, Allen J (2005). Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered. Parasite immunology, 27(9), 317-24. (Read full article)
  10. Lamb TJ, Voisine C, Koernig S, Egan CA, Harnett W, Langhorne (2007). The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES-62. Parasite immunology, 29(5), 271-6. (Read full article)
  11. Graham AL, Taylor MD, Le Goff L, Lamb TJ, Magennis M, Allen J (2005). Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis. Microbes and infection, 7(4), 612-8. (Read full article)
  12. Fairlie-Clarke KJ, Lamb TJ, Langhorne J, Graham AL, Allen J (2010). Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity. BMC immunology, 11, 6. (Read full article)
  13. Lamb TJ, Langhorne (2008). The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites. Malaria journal, 7, 68. (Read full article)
  14. Saunders A, Lamb T, Pascall J, Hutchings A, Dion C, Carter C, Hepburn L, Langhorne J, Butcher G (2009). Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria. Malaria journal, 8, 53. (Read full article)
  15. Abanyie FA, McCracken C, Kirwan P, Molloy SF, Asaolu SO, Holland CV, Gutman J, Lamb T (2013). Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children. Malaria journal, 12, 1. (Read full article)
  16. Joyner C, Moreno A, Meyer EV, Cabrera-Mora M, MaHPIC Consortium, Kissinger JC, Barnwell JW, Galinski MR (2016). Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infections. Malaria journal, 15(1), 451.
  17. Matar CG, Anthony NR, O'Flaherty BM, Jacobs NT, Priyamvada L, Engwerda CR, Speck SH, Lamb T (2015). Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. PLoS pathogens, 11(5), e1004858. (Read full article)
  18. Hudson LE, Fasken MB, McDermott CD, McBride SM, Kuiper EG, Guiliano DB, Corbett AH, Lamb T (2014). Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii. PloS one, 9(11), e112660. (Read full article)
  19. Mimche PN, Brady LM, Keeton S, Fenne DS, King TP, Quicke KM, Hudson LE, Lamb T (2015). Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation. PloS one, 10(9), e0138835. (Read full article)
  20. Hudson LE, McDermott CD, Stewart TP, Hudson WH, Rios D, Fasken MB, Corbett AH, Lamb T (2016). Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System. PloS one, 11(4), e0153351. (Read full article)
  21. Hudson LE, Stewart TP, Fasken MB, Corbett AH, Lamb T (2016). Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice. Journal of visualized experiments, (108), e53453. (Read full article)
  22. Lin J, Sondekamp J, Cunningham D, Deroost K, Tshitenge T, McLaughlin S, Lamb T, Spencer-Dean B, Hosking C, Ramesar J, Janse C, Graham C, O'Garra A, Langhorne (2017). Signatures of malaria-associated pathology revealed by high-resolution whole blood transcriptomicsin a rodent model of malaria. Scientific reports, 7, 41722.
  23. Fogang B, Biabi MF, Megnekou R, Maloba FM, Essangui E, Donkeu C, Cheteug G, Kapen M, Keumoe R, Kemleu S, Nsango S, Eboumbou C, Lamb TJ, Ayong (2021). High Prevalence of Asymptomatic Malarial Anemia and Association with Early Conversion from Asymptomatic to Symptomatic Infection in a Plasmodium falciparum Hyperendemic Setting in Cameroon. The American journal of tropical medicine and hygiene, 106(1), 293-302. (Read full article)
  24. Srey MT, Taccogna A, Oksov Y, Lustigman S, Tai PY, Acord J, Selkirk ME, Lamb TJ, Guiliano D (2020). Vaccination with novel low-molecular weight proteins secreted from Trichinella spiralis inhibits establishment of infection. PLoS neglected tropical diseases, 14(11), e0008842. (Read full article)
  25. Darling TK, Mimche PN, Bray C, Umaru B, Brady LM, Stone C, Eboumbou Moukoko CE, Lane TE, Ayong LS, Lamb T (2020). EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS pathogens, 16(1), e1008261. (Read full article)
  26. Darling TK, Schenk MP, Zhou CC, Maloba FM, Mimche PN, Gibbins JM, Jobe SM, Lamb T (2020). Platelet ¿-granules contribute to organ-specific pathologies in a mouse model of severe malaria. Blood advances, 4(1), 1-8. (Read full article)
  27. Joyner CJ, Brito CFA, Saney CL, Joice Cordy R, Smith ML, Lapp SA, Cabrera-Mora M, Kyu S, Lackman N, Nural MV, DeBarry JD, MaHPIC Consortium., Kissinger JC, Styczynski MP, Lee FE, Lamb TJ, Galinski M (2019). Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes. PLoS pathogens, 15(9), e1007974. (Read full article)
  28. Tunon-Ortiz A, Lamb T (2019). Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation. PLoS pathogens, 15(6), e1007786. (Read full article)
  29. Morgan ET, Dempsey JL, Mimche SM, Lamb TJ, Kulkarni S, Cui JY, Jeong H, Slitt A (2018). Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting. Drug metabolism and disposition, 46(5), 503-513. (Read full article)
  30. Mimche PN, Lee CM, Mimche SM, Thapa M, Grakoui A, Henkemeyer M, Lamb T (2018). EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells. Scientific reports, 8(1), 2532. (Read full article)
  31. Vandermosten L, Pham TT, Possemiers H, Knoops S, Van Herck E, Deckers J, Franke-Fayard B, Lamb TJ, Janse CJ, Opdenakker G, Van den Steen P (2018). Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion. Malaria journal, 17(1), 102. (Read full article)
  32. Tang Y, Joyner CJ, Cabrera-Mora M, Saney CL, Lapp SA, Nural MV, Pakala SB, DeBarry JD, Soderberg S, MaHPIC Consortium., Kissinger JC, Lamb TJ, Galinski MR, Styczynski M (2017). Correction to: Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques. Malaria journal, 16(1), 486. (Read full article)
  33. Qiu Y, Ahn B, Sakurai Y, Hansen CE, Tran R, Mimche PN, Mannino RG, Ciciliano JC, Lamb TJ, Joiner CH, Ofori-Acquah SF, Lam W (2018). Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease. Nature biomedical engineering, 2, 453-463. (Read full article)
  34. Tang Y, Joyner CJ, Cabrera-Mora M, Saney CL, Lapp SA, Nural MV, Pakala SB, DeBarry JD, Soderberg S, MaHPIC Consortium., Kissinger JC, Lamb TJ, Galinski MR, Styczynski M (2017). Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques. Malaria journal, 16(1), 384. (Read full article)

Review

  1. Hudson LE, Anderson SE, Corbett AH, Lamb TJ, (2017). Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies. [Review]. Clin Microbiol Rev, 30, (1), 191-231.
  2. Matar CG, Jacobs NT, Speck SH, Lamb TJ, Moormann A (2015). Does EBV alter the pathogenesis of malaria?. Parasite immunology, 37(9), 433-45. (Read full article)
  3. Fenton A, Lamb T, Graham A (2008). Optimality analysis of Th1/Th2 immune responses during microparasite-macroparasite co-infection, with epidemiological feedbacks. Parasitology, 135(7), 841-53. (Read full article)
  4. Lamb TJ, Graham AL, Petrie (2008). T testing the immune system. Immunity, 28(3), 288-92. (Read full article)
  5. Stephens R, Culleton RL, Lamb T (2012). The contribution of Plasmodium chabaudi to our understanding of malaria. Trends in parasitology, 28(2), 73-82. (Read full article)
  6. Lamb TJ, Brown DE, Potocnik AJ, Langhorne (2006). Insights into the immunopathogenesis of malaria using mouse models. Expert reviews in molecular medicine, 8(6), 1-22. (Read full article)
  7. King T, Lamb (2015). Interferon-gamma: The Jekyll and Hyde of Malaria. PLoS pathogens, 11(10), e1005118. (Read full article)
  8. Lamb TJ, Schenk MP, Todryk S (2010). How do malaria parasites activate dendritic cells?. Future microbiology, 5(8), 1167-71. (Read full article)
  9. Olatunde AC, Cornwall DH, Roedel M, Lamb T (2022). Mouse Models for Unravelling Immunology of Blood Stage Malaria. Vaccines, 10(9), (Read full article)
  10. Olatunde AC, Hale JS, Lamb T (2021). Cytokine-skewed Tfh cells: functional consequences for B cell help. Trends in immunology, 42(6), 536-550. (Read full article)
  11. Pham TT, Lamb TJ, Deroost K, Opdenakker G, Van den Steen P (2021). Hemozoin in Malarial Complications: More Questions Than Answers. Trends in parasitology, 37(3), 226-239. (Read full article)
  12. Kolawole EM, Lamb TJ, Evavold B (2020). Relationship of 2D Affinity to T Cell Functional Outcomes. International journal of molecular sciences, 21(21), (Read full article)
  13. Darling TK, Lamb T (2019). Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity. Frontiers in immunology, 10, 1473. (Read full article)