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Tracey J. Lamb

Tracey J. Lamb, PhD

Languages spoken: English

Academic Information

Departments Primary - Pathology

Academic Office Information

Research Interests

  • Malaria Immunopathogenesis

Selected Publications

Journal Article

  1. Fogang B, Biabi MF, Megnekou R, Maloba FM, Essangui E, Donkeu C, Cheteug G, Kapen M, Keumoe R, Kemleu S, Nsango S, Eboumbou C, Lamb TJ, Ayong L (2021). High Prevalence of Asymptomatic Malarial Anemia and Association with Early Conversion from Asymptomatic to Symptomatic Infection in a Plasmodium falciparum Hyperendemic Setting in Cameroon. Am J Trop Med Hyg, 106(1), 293-302.
  2. Srey MT, Taccogna A, Oksov Y, Lustigman S, Tai PY, Acord J, Selkirk ME, Lamb TJ, Guiliano DB (2020). Vaccination with novel low-molecular weight proteins secreted from Trichinella spiralis inhibits establishment of infection. PLoS Negl Trop Dis, 14(11), e0008842.
  3. Darling TK, Mimche PN, Bray C, Umaru B, Brady LM, Stone C, Eboumbou Moukoko CE, Lane TE, Ayong LS, Lamb TJ (2020). EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog, 16(1), e1008261.
  4. Darling TK, Schenk MP, Zhou CC, Maloba FM, Mimche PN, Gibbins JM, Jobe SM, Lamb TJ (2019). Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria. Blood Adv, 4(1), 1-8.
  5. Joyner CJ, Brito CFA, Saney CL, Joice Cordy R, Smith ML, Lapp SA, Cabrera-Mora M, Kyu S, Lackman N, Nural MV, DeBarry JD, MaHPIC Consortium, Kissinger JC, Styczynski MP, Lee FE, Lamb TJ, Galinski MR (2019). Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes. PLoS Pathog, 15(9), e1007974.
  6. Tunon-Ortiz A, Lamb TJ (2019). Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation. PLoS Pathog, 15(6), e1007786.
  7. Morgan ET, Dempsey JL, Mimche SM, Lamb TJ, Kulkarni S, Cui JY, Jeong H, Slitt AL (2018). Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting. Drug Metab Dispos, 46(5), 503-513.
  8. Vandermosten L, Pham TT, Possemiers H, Knoops S, Van Herck E, Deckers J, Franke-Fayard B, Lamb TJ, Janse CJ, Opdenakker G, Van den Steen PE (2018). Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion. Malar J, 17(1), 102.
  9. Mimche PN, Lee CM, Mimche SM, Thapa M, Grakoui A, Henkemeyer M, Lamb TJ (2018). EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells. Sci Rep, 8(1), 2532.
  10. Qiu Y, Ahn B, Sakurai Y, Hansen CE, Tran R, Mimche PN, Mannino RG, Ciciliano JC, Lamb TJ, Joiner CH, Ofori-Acquah SF, Lam WA (2018). Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease. Nat Biomed Eng, 2, 453-463.
  11. Tang Y, Joyner CJ, Cabrera-Mora M, Saney CL, Lapp SA, Nural MV, Pakala SB, DeBarry JD, Soderberg S, MaHPIC Consortium, Kissinger JC, Lamb TJ, Galinski MR, Styczynski MP (2017). Correction to: Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques. Malar J, 16(1), 486.
  12. Tang Y, Joyner CJ, Cabrera-Mora M, Saney CL, Lapp SA, Nural MV, Pakala SB, DeBarry JD, Soderberg S, MaHPIC Consortium, Kissinger JC, Lamb TJ, Galinski MR, Styczynski MP (2017). Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques. Malar J, 16(1), 384.
  13. Lin J, Sondekamp J, Cunningham D, Deroost K, Tshitenge T, McLaughlin S, Lamb T, Spencer-Dean B, Hosking C, Ramesar J, Janse C, Graham C, OGarra A, Langhorne J (2017). Signatures of malaria-associated pathology revealed by high-resolution whole blood transcriptomicsin a rodent model of malaria. Sci Rep, 7, 41722.
  14. Hudson LE, Stewart TP, Fasken MB, Corbett AH, Lamb TJ (2016). Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice. J Vis Exp, (108), e53453.
  15. Hudson LE, McDermott CD, Stewart TP, Hudson WH, Rios D, Fasken MB, Corbett AH, Lamb TJ (2016). Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System. PLoS One, 11(4), e0153351.
  16. Joyner C, Moreno A, Meyer EV, Cabrera-Mora M, MaHPIC Consortium, Kissinger JC, Barnwell JW, Galinski MR (2016). Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infections. Malar J, 15(1), 451.
  17. Mimche PN, Brady LM, Bray CF, Lee CM, Thapa M, King TP, Quicke K, McDermott CD, Mimche SM, Grakoui A, Morgan ET, Lamb TJ (2015). The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. Hepatology, 62(3), 900-14.
  18. Matar CG, Anthony NR, OFlaherty BM, Jacobs NT, Priyamvada L, Engwerda CR, Speck SH, Lamb TJ (2015). Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. PLoS Pathog, 11(5), e1004858.
  19. Mimche PN, Brady LM, Keeton S, Fenne DS, King TP, Quicke KM, Hudson LE, Lamb TJ (2015). Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation. PLoS One, 10(9), e0138835.
  20. Hudson LE, Fasken MB, McDermott CD, McBride SM, Kuiper EG, Guiliano DB, Corbett AH, Lamb TJ (2014). Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii. PLoS One, 9(11), e112660.
  21. Abanyie FA, McCracken C, Kirwan P, Molloy SF, Asaolu SO, Holland CV, Gutman J, Lamb TJ (2013). Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children. Malar J, 12, 1.
  22. Freitas do Rosario AP, Lamb T, Spence P, Stephens R, Lang A, Roers A, Muller W, OGarra A, Langhorne J (2012). IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol, 188(3), 1178-90.
  23. Fairlie-Clarke KJ, Lamb TJ, Langhorne J, Graham AL, Allen JE (2010). Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity. BMC Immunol, 11, 6.
  24. Saunders A, Lamb T, Pascall J, Hutchings A, Dion C, Carter C, Hepburn L, Langhorne J, Butcher GW (2009). Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria. Malar J, 8, 53.
  25. Cadman ET, Abdallah AY, Voisine C, Sponaas AM, Corran P, Lamb T, Brown D, Ndungu F, Langhorne J (2008). Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity. Infect Immun, 76(9), 3924-31.
  26. Lamb TJ, Langhorne J (2008). The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites. Malar J, 7, 68.
  27. Lamb TJ, Harris A, Le Goff L, Read AF, Allen JE (2008). Litomosoides sigmodontis: vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection. Exp Parasitol, 118(2), 285-9.
  28. Lamb TJ, Voisine C, Koernig S, Egan CA, Harnett W, Langhorne J (2007). The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES-62. Parasite Immunol, 29(5), 271-6.
  29. Lamb TJ, Graham AL, Le Goff L, Allen JE (2005). Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered. Parasite Immunol, 27(9), 317-24.
  30. Graham AL, Taylor MD, Le Goff L, Lamb TJ, Magennis M, Allen JE (2005). Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis. Microbes Infect, 7(4), 612-8.
  31. Graham AL, Lamb TJ, Read AF, Allen JE (2005). Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency. J Infect Dis, 191(3), 410-21.
  32. Lamb TJ, Le Goff L, Kurniawan A, Guiliano DB, Fenn K, Blaxter ML, Read AF, Allen JE (2004). Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage. J Infect Dis, 189(1), 120-7.
  33. Le Goff L, Lamb TJ, Graham AL, Harcus Y, Allen JE (2002). IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. Int J Parasitol, 32(10), 1277-84.
  34. Djikeng A, Ferreira L, DAngelo M, Dolezal P, Lamb T, Murta S, Triggs V, Ulbert S, Villarino A, Renzi S, Ullu E, Tschudi C (2001). Characterization of a candidate Trypanosoma brucei U1 small nuclear RNA gene. Mol Biochem Parasitol, 113(1), 109-15.


  1. Olatunde AC, Cornwall DH, Roedel M, Lamb TJ (2022). Mouse Models for Unravelling Immunology of Blood Stage Malaria. [Review]. Vaccines (Basel), 10(9).
  2. Olatunde AC, Hale JS, Lamb TJ (2021). Cytokine-skewed Tfh cells: functional consequences for B cell help. [Review]. Trends Immunol, 42(6), 536-550.
  3. Pham TT, Lamb TJ, Deroost K, Opdenakker G, Van den Steen PE (2020). Hemozoin in Malarial Complications: More Questions Than Answers. [Review]. Trends Parasitol, 37(3), 226-239.
  4. Kolawole EM, Lamb TJ, Evavold BD (2020). Relationship of 2D Affinity to T Cell Functional Outcomes. [Review]. Int J Mol Sci, 21(21).
  5. Darling TK, Lamb TJ (2019). Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity. [Review]. Front Immunol, 10, 1473.
  6. Hudson LE, Anderson SE, Corbett AH, Lamb TJ (2017). Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies. [Review]. Clin Microbiol Rev, 30(1), 191-231.
  7. King T, Lamb T (2015). Interferon-gamma: The Jekyll and Hyde of Malaria. [Review]. PLoS Pathog, 11(10), e1005118.
  8. Matar CG, Jacobs NT, Speck SH, Lamb TJ, Moormann AM (2015). Does EBV alter the pathogenesis of malaria? [Review]. Parasite Immunol, 37(9), 433-45.
  9. Stephens R, Culleton RL, Lamb TJ (2012). The contribution of Plasmodium chabaudi to our understanding of malaria. [Review]. Trends Parasitol, 28(2), 73-82.
  10. Lamb TJ, Schenk MP, Todryk SM (2010). How do malaria parasites activate dendritic cells? [Review]. Future Microbiol, 5(8), 1167-71.
  11. Fenton A, Lamb T, Graham AL (2008). Optimality analysis of Th1/Th2 immune responses during microparasite-macroparasite co-infection, with epidemiological feedbacks. [Review]. Parasitology, 135(7), 841-53.
  12. Lamb TJ, Graham AL, Petrie A (2008). T testing the immune system. [Review]. Immunity, 28(3), 288-92.
  13. Lamb TJ, Brown DE, Potocnik AJ, Langhorne J (2006). Insights into the immunopathogenesis of malaria using mouse models. [Review]. Expert Rev Mol Med, 8(6), 1-22.

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