John W. Rose, MD

Overview

Within the division, my focus is on Multiple Sclerosis clinical care and research. Our clinic is a Partner in Care with the National Multiple Sclerosis Society and designated a Comprehensive Care Center. We have ongoing clinical investigations of neurogenic pain, OCT and immunotherapies. One special area of research is Pediatric Multiple Sclerosis including clinical and translational investigations. Another important area is development of Magnetic Resonance Imaging for detection of demyelination and remyelination.

Please view my faculty profile here.

My favorite sport is lacrosse.

I see patients at . . .

University of Utah, a Partner in Care with the National Multiple Sclerosis Society and designated a Comprehensive Care Center. 

Current Research Projects & Funding

NMSS Grant: Charles Casper (PI) & John Rose (CoPI). Renewal of Pediatric MS Network. Purpose: Acquire, curate and analyze data for the US Network of Pediatric Multiple Sclerosis Centers. In addition, contribute to the USNPMSC steering committee and assist with proposals, manuscripts and grants for the network.

VA Merit Review: EK Jeong (PI) and John Rose (Co-I). Quantitation of myelin damage in optic nerve, brainstem, cervical spinal cord, and corpus-callosum in MS. Purpose: Utilize new imaging technology including Ultra High b DWI to detect demyelination and remyelination in preclinical models and patients with Multiple Sclerosis. Imaging will focus on Cervical Spinal Cord, Optic Nerves and Corpus Callosum in the models and the MS patients.

Guthy Jackson Charitable Foundation (Cook PI and Rose, Co-Investigator). Data Coordinating Center for Neuromyelitis Optic. Pupose: Develop registries and bio-repositories for the Foundation.  Including biological specimens, MRI and OCT resources. Obtain, quality review, and analyze data from the 16 medical centers currently participating in these projects.

PCORI/NIH TREAT-MS (Rose, Site PI). Pupose: Study of Early Therapy of Multiple Sclerosis with clinical, MRI, OCT and patient centered outcome measures. This critical multi-center study will determine relative efficacy of MS therapeutics in relapsing and remitting MS patients with special attention to newer highly active disease.

Biogen: (Rose, PI, Wong Co-PI): Longitudinal Assessment of Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis on Avonex.

D&R Foundation: (Rose, PI, Wong Co-PI): Study of Clinical Care and DMT Access in Young Adults with MS.

Professional Affiliations & Leadership Roles

• American Academy of Neurology (AAN FAAN)
• American Academy for Advancement of Science (AAS)
• International Pediatric Multiple Sclerosis Study Group (IPMSSG)
• Paralyzed Veterans of America, Member
• Chair, Advisory Committee for VA MS Centers of Excellence West 2004 to 2023
• Chair, VA MSCoE East/West Neurology Advisory Subcommittee (NCAS) 2021–2022
• Board Member, Nevada, Idaho & Utah Chapter of NMSS 2012 to Present
• US Network of Pediatric MS Centers, Steering Committee Member 2012 to Present

Awards, Honors, and Recognitions

• Above and Beyond Award:  Utah Chapter of the National Multiple Sclerosis Society 2001
• Outstanding Volunteer Service:  Research & Clinical Services from National MS Society 2005
• T.K. McCarthey Silver Hope Award from the Utah/Southern Idaho Chapter of the NMSS 2011
• Utah Business Health Care Hero (with Charles Casper) for Innovation in Pediatric MS 2012
• National Multiple Sclerosis Society Research Programs Advisory Committee 2007-2013
• Jay Gurmankin Leadership Award from the Utah/Southern Idaho Chapter of the NMSS 2014
• Press Ganey Survey, Top 1% Nationally For Patient Satisfaction 2014
• John N. Whitaker Memorial Lecturer, Paralyzed Veterans of America Summit Meeting 2016
• Distinguished Visiting Professor OHSU, Neuroscience Research Day 2018
• Biogen MS Clinical Fellowship Jason Poon (Fellow)and John Rose (Mentor) 2020
• NMSS Clinical Fellowship: Sarah Germaine (Fellow) and John Rose (Mentor) 2022
• VA Multiple Sclerosis Centers of Excellence-Certificate of Appreciation 2023
• EMD Serono Fellowship Grant 2025 Yibing Zhang (Fellow), Melissa Wright, Ka-Ho Wong & John Rose (Mentors) 2025

Key Publications

Clinical Trials and Clinical Investigations in MS:

1. Rose JW, Watt HE, White A and Carlson NG.  Treatment of multiple sclerosis with daclizumab:  a humanized monoclonal antibody specific for interleukin 2 receptor alpha chain. Annals of Neurology 56:864-867, 2004.
2. Krysko KM, Graves J, Rensel M, Weinstock-Guttman B, Aaen G, Benson L, Chitnis T, Gorman M, Goyal M, Krupp L, Lotze T, Mar S, Rodriguez M, Rose J, Waltz M, Charles Casper T, Waubant E; US Network of Pediatric MS Centers. Use of newer disease-modifying therapies in pediatric multiple sclerosis, Neurology. 2018 Nov 6;91(19):e1778-e1787.
3. Burt RK, Balabanov R, Burman J, Sharrack B, Snowden JA, Oliveira MC, Fagius J, Rose J, Nelson F, Barreira AA, Carlson K, Han X, Moraes D, Morgan A, Quigley K, Yaung K, Buckley R, Alldredge C, Clendenan A, Calvario MA, Henry J, Jovanovic B, Helenowski IB. Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial. JAMA. 2019 Jan 15;321(2):165-174.
4. Krysko KM, Graves JS, Rensel M, Weinstock-Guttman B, Rutatangwa A, Aaen G, Belman A, Benson L, Chitnis T, Gorman M, Goyal MS, Harris Y, Krupp L, Lotze T, Mar S, Moodley M, Ness J, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waltz M, Casper TC, Waubant E; US Network of Pediatric MS Centers. Real-world effectiveness of initial disease-modifying therapies in pediatric MS. Ann Neurol. 2020 Jul;88 (1):42-55. PMID 32267005

Therapeutics and Neuropathology in Models:

1. Rose JW, Hill KE, Watt HE and Carlson NG. Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion. J Neuroimmunol 149:40-49, 2004.
2. Carlson N, Hill K, Tsunoda I, Fujinami R and Rose JW. The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: Implications for multiple sclerosis. J Neuroimmunology 174(1-2):21-31, 2006.
3. Carlson NG, Rojas MA, Redd JW, Tang P, Wood B, Hill KE, Rose JW. Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death. J Neuroinflammation 7:25, 2010.
4. Carlson NG, Bellamkinda S, Schmidt L, Redd J, Huecksteadt T, Weber LM, Davis E, Wood B, Maruyama T and Rose JW. The role of prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death. J Neuroinflammation, 12: 101, 2015.

Investigations of Pediatric MS and NMOSD:

1. Belman AL, Krupp LB, Olsen CS, Rose JW, Aaen G, Benson L, Chitnis T, Gorman M, Graves J, Harris Y, Lotze T, Ness J, Rodriguez M, Tillema JM, Waubant E, Weinstock-Guttman B, Casper TC ; US Network of Pediatric MS Centers. Charactersitics of children and adolescents with multiple sclerosis. Pediatrics. Jul;138(1), 2016.
2. Cook L, Rose JW, Alvey J, Jolley AM, et al. Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD. Neurology: Neuroimmunology & Neuroinflammation. 2019 Jun 28;6(5):e583. PMID: 31355319
3. Krysko KM, Graves JS, Rensel M, Weinstock-Guttman B, Rutatangwa A, Aaen G, Belman A, Benson L, Chitnis T, Gorman M, Goyal MS, Harris Y, Krupp L, Lotze T, Mar S, Moodley M, Ness J, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waltz M, Casper TC, Waubant E; US Network of Pediatric MS Centers. Real-world efficacy of initial disease-modifying in pediatric multiple sclerosis. Ann Neurol. 2020 Jul;88(1):42-55. PMID: 32267005
4. Chitnis T, Aaen G, Belman A, Benson L, Gorman M, Goyal MS, Graves JS, Harris Y, Krupp L, Lotze T, Mar S, Ness J, Rensel M, Schreiner T, Tillema JM, Waubant E, Weinstock-Guttman B, Roalstad S, Rose J, Weiner HL, Casper TC, Rodriguez M; US Network of Paediatric Multiple Sclerosis Centers. Improved recovery from relapse in paediatric compared to adult multiple sclerosis. Brain. 2020 Sep 1;143(9):2733-2741. PMID: 32810215

Biomarkers and MRI:

1. Martins T, Rose JW, Jaskowski T, Wilson A, Husebye D, Seraj H, and Hill H. Analysis of pro and anti-Inflammatory cytokine serum concentrations in multiple sclerosis patients utilizing a multiplexed Immunoassay. American Journal of Clinical Pathology 136: 696-704, 2011.
2. Carlson N and Rose JW. Vitamin D as a clinical biomarker in multiple sclerosis. Expert Opinion On Medical Diagnostics, 7(3):231-42. 2013.
3. Loughran-Fjeldstad AS, Carlson NG, Husebye CD, Cook LJ, Rose JW. Retinal Nerve Fiber layer sector-specific compromise in relapsing and remitting MS. eNeurologicalSci. 2015 Oct 9;1:30-37
4. Chan A, Rose J, Alvarez E, Bar-Or A, Butzkueven H, Fox RJ, Gold R, Gudesblatt M, Haartsen J, Spelman T, Wright K, Ferraro D, Sola P, Hodgkinson S, Kalincik T, Lechner-Scott J, McGuigan C, Spach K, Chen C, Fam S, Wu F, Miller C. Lymphocyte reconstitution after DMF discontinuation in clinical trial and real-world patients with MS. Neurol Clin Pract. 2020 Dec;10(6):510-519. PMID: 33510947

MRI and Pathologic Correlates:

1. Zollinger LV, Kim TH, Hill K, Jeong EK, Rose JW. Using diffusion tensor imaging and immunofluorescent assay to evaluate the pathology of multiple sclerosis. J Magn Reson Imaging. 33(3):557-64, 2010.
2. Merrill R, Hadley R, Minalga E, Kholmovaski E, Vijayakumr S, Kim S-E, Quigley E, Parker D and Rose JW. A 28-channel coil for improved magnetic resonance imaging of the optic nerve. Concepts in Magnetic Resonance Part B (Magnetic Resonance Engineering) 41B(1): 73-84, 2012.
3. Sapkota N, Shah L, Bisson E, Rose JW and Jeong EK. Two-Dimensional single-shot diffusion-weighted stimulated EPI with reduced FOV for ultrahigh-b radial diffusion-weighted imaging of spinal cord. Magnetic Resonance in Medicine (MRM). 77: 2167-2173, 2017.
4. Thapa B, Sapkota N, Lee Y, Jeong K, Rose J, Shah LM, Bisson E, Jeong EK. Ultra-high-b radial diffusion-weighted imaging (UHb-rDWI) of human cervical spinal cord. J Magn Reson Imaging. 2019 Jan;49(1):204-211.
5. Kyle Erjin Jeong, Ph.D.; Lubdha M. Shah, MD; You-Jung Lee; Bijaya Thapa, PhD; Nabraj Sapkota, PhD; Erica Bisson, MD, MPH; Noel Carlson, PhD; E.K. Jeong, PhD and John Rose. High-b Diffusivity of MS Lesion in Cervical Spinal Cord using Ultrahigh-b DWI (UHb-DWI). Neuroimage: Clinical. 2021 30:102625, epub ahead of print March 2021.