Publications

For a copy of any of the below articles, please email sarah.lopez@hsc.utah.edu.

APS & Lupus Related Publications

Branch DW. (2004). Pregnancy in patients with rheumatic diseases: obstetric management and monitoring. Lupus, 13(9), 696-8.

Branch DW, Rote NS, Dostal DA, Scott JR. (1987). Association of lupus anticoagulant with antibody against phosphatidylserine. Clin Immunol Immunopathol, 42(1), 63-75.

Branch DW, Rote NS, Scott JR. (1986). The demonstration of lupus anticoagulant by an enzyme-linked immunoadsorbent assay. Clin Immunol Immunopathol, 39(2), 298-307.

Branch DW, Scott JR, Kochenour NK, Hershgold E. (1985). Obstetric complications associated with the lupus anticoagulant. N Engl J Med, 313(21), 1322-6.

Silver RM, Porter TF, van Leeuwen I, Coulam C, Jeng G, Scott JR, Branch DW. Anticardiolipin antibodies: Clinical consequences of low titers. Obstet Gynecol 1996;87:494-500.Pierangeli SS, Dean J, Goldsmith GH,

Branch DW, Gharavi A, Harris EN. (1996). Studies on the interaction of placental anticoagulant protein I, beta 2 glycoprotein 1, and antiphospholipid antibodies in the prothrombinase reaction and in the solid phase anticardiolipin assays. J Lab Clin Med, 128(2), 194-201.

Branch DW, Silver RM, Blackwell J, Reading J, Scott JR: Outcome of treated pregnancies in women with antiphospholipid syndrome: An update of the Utah experience. Obstet Gynecol 1992;80:614-20

Silver RM, Draper ML, Lyon JL, Byrne JL, Ashwood EA, Branch DW: Unexplained elevations of maternal serum alpha-fetoprotein in women with antiphospholipid antibodies: A harbinger of fetal death. Obstet Gynecol, 1994;83:150-5

Silver RM, Draper ML, Scott JR, Lyon JL, Reading J, Branch DW: Clinical consequences of antiphospholipid antibodies: An historical cohort study. Obstet Gynecol, 1994;83:372-7.

Dizon-Townson D, Hutchison C, Silver RM, Branch DW, Ward K. The factor V Leiden mutation which predisposes to thrombosis is not common in patients with antiphospholipid syndrome. Thromb Hemostas 1995;74:1029-31.

Oshiro BT, Silver RM, Scott JR, Yu H, Branch DW. Antiphospholipid antibodies and fetal death. Obstet Gynecol 1996;87:489-93.

Branch DW, Silver RM. Criteria for antiphospholipid syndrome: early pregnancy loss, fetal loss, or recurrent pregnancy loss? Lupus 1996;5:409-13.

Branch DW, Silver RM, Pierangeli SS, van Leeuwen I, Harris EN. Antiphospholipid antibodies other than lupus anticoagulant are not associated with recurrent pregnancy loss. Obstet Gynecol 1997;89:549-55.

Silver RM, Pierangeli SS, Edwin SS, Umar F, Harris EN, Scott JR, Branch DW. Pathogenic antibodies in women with obstetric features of antiphospholipid syndrome who test negative for lupus anticoagulant and anticardiolipin antibodies. Am J Obstet Gynecol 1997;176:628-33.

Silver RM, Smith LA, Edwin SS, Oshiro BT, Scott JR, Branch DW. Variable effects of immunoglobulin G fractions from women with antiphopholipid antibodies on murine pregnancy. Am J Obstet Gynecol 1997;177:229-33.

Gharavi AE, Cucurull E, Tang H, Silver RM, Branch DW. Effect of antiphsopholipid antibodies on beta-2-glycoprotein I-phospholipid interaction. Am J Reprod Immunol 1998; 39:310-5.

Clark AL, Branch DW, Silver RM, Harris EN, Pierangeli S, Spinnato JA. Pregnancy complicated by the antiphospholipid syndrome: Outcomes with intravenous immunoglobulin therapy. Obstet Gynecol 1999;93:437-4.

Kutteh WH, Rote NS, Silver RM. Antiphospholipid antibodies and reproduction. Am J Reprod Immunol 1999;41:133-154.

Pregnancy loss study group (Branch DW, Druzin M, El-Sayed Y,Esplin MS, Hrager J, Peaceman AM, Silver RK, Silver RM, Spinnato J). A multicenter, controlled, pilot study of intravenous immune globulin treatment of antiphospholipid syndrome in pregnancy. Am J Obstet Gynecol, 2000, 182;122-7.

Van-Horn JT, Craven C, Ward K, Branch DW, Silver RM. Histologic features of gestational tissues from women with antiphospholipid and antiphospholipid-like syndromes. Placenta 2004;25:642-8.

Lee RM, Brown MA, Ward K, Nelson L, Branch DW, Silver RM. Homocysteine levels in women with antiphospholipid syndrome and normal fertile controls. Journal Reprod Immunol 2004;63:23-30.

Bowman ZS, Wunsche V, Porter TF, Silver RM, Branch DW. Prevalence of antiphospholipid antibodies and risk of subsequent adverse obstetrical outcomes in women with prior pregnancy loss. J Reprod Immunol 2015;107:59-63.

Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, DE Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA. (2006). International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost, 4(2), 295-306.

Van Horn JT, Craven C, Ward K, Branch DW, Silver RM. (2004). Histologic features of placentas and abortion specimens from women with antiphospholipid and antiphospholipid-like syndromes. Placenta, 25(7), 642-8.

Branch DW. (2004). Antiphospholipid antibodies and fetal compromise. Thromb Res, 114(5-6), 415-8.

Branch DW, Porter TF, Rittenhouse L, Caritis S, Sibai B, Hogg B, Lindheimer MD, Klebanoff M, MacPherson C, VanDorsten JP, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G. (2001). Antiphospholipid antibodies in women at risk for preeclampsia. Am J Obstet Gynecol, 184(5), 825-32; discussion 832-4.

Gharavi AE, Cucurull E, Tang H, Silver RM, Branch DW. (1998). Effect of antiphospholipid antibodies on beta(2) glycoprotein I-phospholipid Interaction. Am J Reprod Immunol, 39(5), 310-5.

Horkko S, Miller E, Branch DW, Palinski W, Witztum JL. (1997). The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins). Proc Natl Acad Sci U S A, 94(19), 10356-61.

Silver RM, Smith LA, Edwin SS, Oshiro BT, Scott JR, Branch DW. (1997). Variable effects on murine pregnancy of immunoglobulin G fractions from women with antiphospholipid antibodies. Am J Obstet Gynecol, 177(1), 229-33.

Pierangeli SS, Goldsmith GH, Branch DW, Harris EN. (1997). Antiphospholipid antibody: functional specificity for inhibition of prothrombin activation by the prothrombinase complex. Br J Haematol, 97(4), 768-74.

Horkko S, Miller E, Dudl E, Reaven P, Curtiss LK, Zvaifler NJ, Terkeltaub R, Pierangeli SS, Branch DW, Palinski W, Witztum JL. (1996). Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein. J Clin Invest, 98(3), 815-25.

Goldsmith GH, Pierangeli SS, Branch DW, Gharavi AE, Harris EN. (1994). Inhibition of prothrombin activation by antiphospholipid antibodies and beta 2-glycoprotein 1. Br J Haematol, 87(3), 548-54.
Silver RM, Branch DW. (1994). Should you treat women who have antiphospholid syndrome? Contemp Ob-Gyn, 39, 63-83.

Pierangeli SS, Harris EN, Gharavi AE, Goldsmith G, Branch DW, Dean WL. (1993). Are immunoglobulins with lupus anticoagulant activity specific for phospholipids? Br J Haematol, 85(1), 124-32.
Branch DW, Rodgers GM. (1993). Induction of endothelial cell tissue factor activity by sera from patients with antiphospholipid syndrome: a possible mechanism of thrombosis. Am J Obstet Gynecol, 168(1 Pt 1), 206-10.

Pollard JK, Scott JR, Branch DW. (1992). Outcome of children born to women treated during pregnancy for the antiphospholipid syndrome. Obstet Gynecol, 80(3 Pt 1), 365-8.

Branch DW, Dudley DJ, Mitchell MD, Creighton KA, Abbott TM, Hammond EH, Daynes RA. (1990). Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss. Am J Obstet Gynecol, 163(1 Pt 1), 210-6.

Dudley DJ, Mitchell MD, Branch DW. (1990). Pathophysiology of antiphospholipid antibodies: absence of prostaglandin-mediated effects on cultured endothelium. Am J Obstet Gynecol, 162(4), 953-8; discussion 958-9.

Dostal-Johnson D, Rote NS, Branch DW. (1990). IgG1 and IgG2 are the predominant subclasses of antiphospholipid antibody in women with the lupus anticoagulant. Clin Immunol Immunopathol, 54(2), 309-19.

Branch DW, Andres R, Digre KB, Rote NS, Scott JR. (1989). The association of antiphospholipid antibodies with severe preeclampsia. Obstet Gynecol, 73(4), 541-5.

Digre KB, Durcan FJ, Branch DW, Jacobson DM, Varner MW, Baringer JR. (1989). Amaurosis fugax associated with antiphospholipid antibodies. Ann Neurol, 25(3), 228-32.

Kochenour NK, Branch DW, Rote NS, Scott JR. (1987). A new postpartum syndrome associated with antiphospholipid antibodies. Obstet Gynecol, 69(3 Pt 2), 460-8.

Fetal Death-Related Publications

Silver RM, Lohner SL, Daynes RA, Mitchell MD, Branch DW. Lipopolysaccharide-Induced fetal death is caused by a maternal reaction and appears to be mediated by tumor necrosis factor α: evidence from the lipopolysaccharide-hyporesponsive murine strain, C3H/HeJ. Biol of Reprod, 1994;50:1108-12

Silver RM, Edwin SS, Trautman MS, Simmons DL, Branch DW, Dudley DJ, Mitchell MD. Bacterial lipopolysaccharide mediated fetal death: Production of a newly- recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. J Clin Invest, 1995;95:725-31.

Silver RM, Yang L, Daynes RA, Branch DW, Weis JJ. Fetal outcome in murine Lyme disease. Infect Immun 1995;63:66-72.

Silver RM, Pierangelli SS, Gharavi AE, Harris EN, Edwin SS, Salafia CM, Branch DW. Induction of high levels of anticardiolipin antibodies in mice by immunization with ß2-glycoprotein I does not cause fetal death. Am J Obstet Gynecol 1995;173:1410-5.

Silver RM, Edwin SS, Umar F, Dudley DJ, Branch DW, Mitchell MD. Bacterial lipopolysaccharide-mediated fetal death: The role of interleukin-1. Am J Obstet Gynecol 1997;176:544-9.

Frias AE, Luikenaar RA, Sullivan AE, Porter TF, Branch DW, Silver RM. Poor obstetric outcome in subsequent pregnancies in women with prior fetal death. Obstet Gynecol 2004;104:521-6.

Sullivan AE, Nelson L, Rice JA, Porter TF, Branch DW, Silver RM. The factor V Leiden and the G20210A prothrombin gene mutations are rare in women with fetal death. Am J Reprod Immunol 2005;54:1-4.

Silver RM. Fetal death. Obstet Gynecol, 2007; 109:153-67. puerperal sepsis: The association of M protein serotype and exotoxin genes with morbidity. In press, Am J Reprod Immunol.

Warren JE, Turok DK, Maxwell TM, Brothman AR, Silver RM. Array comparative genomic hybridization (aCGH) for genetic evaluation of fetal loss between 10 and 20 weeks gestation. Obstet Gynecol 2009;114:1093-1102..

Dudley DJ, Goldenberg R, Conway D, Silver RM, Saade G, Varner MV, Pinar H, Coustan D, Bukowski R, Stoll B, Koch M, parker C, Willinger M, Reddy UM. Stillbirth Collaborative Research Network: Initial Causes of Fetal Death (INCODE). Obstet Gynecol 2010;116:254-60.

Conway DL, Hansen N, Dudley DJ, Parker CB, Reddy UM, Silver RM, Bukowski R, Pinar H, Stoll BJ, Varner MW, Saade GR, Hogue C, Willinger M, Coustan D, Koch M, Goldenberg RL. A new algorithm for the determination of gestational age at the time of fetal death. Paediatric and Perinatal Epidemiol 2013;27:145-57.

Christiansen-Lindquist L, Silver RM, Parker CB, Dudley DJ, Koch MA, Reddy UM, Saade GR, Goldenberg RL, Hogue CJR, Fetal death certificate data quality: a tale of two U.S. counties. Annals Epidemiol 2017;27:466-71. doi:10.106/j.annepidem.2017.07.001.

Wojcieszek AM, Reinebrant HE, Leisher SH, Allanson E, Coory M, Erwich JJ, Froen JF, Gardosi J, Gordijn S, Gulmezoglu M, Heazell AEP, Koretweg FJ, Lawn JE, McLure E, Pattinson R, Silver RM, Smith G, Teoh Z, Tuncalp O, Flenady V. Characteristics of a global classification system for perinatal deaths: A Delphi consensus study. BMC Pregnancy and Childbirth 2016 Aug 15;16:223.

Gardiner PA, Kent AL, Rodriguez V, Wojcieszek AM, Ellwood D, Gordon A, Wilson T, Bond D, Charles A, Arbuckle S, Gardener G, Oats J, Erwich JJ, Korteweg F, Nguyen DTH, Leisher SH, Kishmore K, Silver RM, Heazell A, Storey C, Flenady V. Evaluation of an international education programme for health care professionals on best practice around the time of a perinatal death: Improving Perinatal mortality Review and Outcomes Via education (IMPROVE). BMC Pregnancy and Childbirth 2016;16:376.

Gardiner PA, Kent AL. Rodriquez V. Wojcieszek AM, Ellwood D, Gordon A, Wilson PA, Bond DM, Charles A, Arbuckle S, Gardener GJ, Oats JJ, Erwich JJ, Korteweg FJ, Duc TH, Leisher SH, Kishore K, Silver RM, Heazell AE, Storey C, Flenady V. Evaluation of an international educational programme for health care professionals on best practice in the management of a perinatal death: Improving Perinatal mortality Review and Outcomes Via Education (IMPROVE). BMC Pregnancy Childbirth 2016;16:376.

Silver RM, Edwin SS, Umar F, Dudley DJ, Branch DW, Mitchell MD. (1997). Bacterial lipopolysaccharide-mediated murine fetal death: the role of interleukin-1. Am J Obstet Gynecol, 176(3), 544-9.

Cowchock FS, Reece EA, Balaban D, Branch DW, Plouffe L. (1992). Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol, 166(5), 1318-23.

Low Dose Aspirin Studies

Schisterman EF, Silver RM, Perkins NJ, Mumford SL, Whitcomb BW, Stanford J, Lesher LL, Faraggi D, Wactawski-Wende J, Browne RW, Townsend JM, Mark White, Lynch AM, , Galai N. A randomized trial to evaluate the effects of low dose Aspirin in Gestation and Reproduction (EAGeR): Design and baseline characteristics. Paediatr and Perinatal Epidemiol 2013;27:598-609.

Schisterman EF, Silver RM, Lesher LL, Faraggi D, Wactawski-Wende J, Townsend JM, Lynch AM, Perkins NJ, Mumford SL, Galai N. Preconception low dose aspirin and pregnancy outcomes: Findings from the EAGeR (Effects of Aspirin in Gestation and Reproduction) Randomized Trial. Lancet 2014; 384:29-36.

Silver RM, Ahrens K, Wong LF, Perkins NJ, Galai N, Lesher LL, Faraggi D, Wactawski-Wende J, Townsend JM, Lynch AM, Mumford SL, Schisterman EF. Preconception low dose aspirin and preterm birth: Findings from the EAGeR (Effects of aspirin in gestation and reproduction) randomized trial. Obstet Gynecol 2015; 125:876-84.

Schisterman EF, Mumford SL, Schleip KC, Sjaarda LA, Stanford JB, Lesher LL, Wactawski-Wnde J, Lynch AM, Townsend JM, Perkins NJ, Zarek SM, Tsai MY, Chen Z, Faraggi D, Galai N, Silver RM. Preconception low dose aspirin and time to pregnancy: Findings form the EAGeR (Effects of Aspirin in Gestation and Reproduction) Randomized Trial. J Clin End Met 2015;100:1785-91.

Lesher LL, Matyas R, Newman S, Silver RM, Galai N, Hovey K, Wactawski-Wende J, Emerick L, Lynch A, Mead B, Townsend J, Perkins N, Mumford S, Stanford J, Schisterman E. Recruitment for longitudinal pregnancy randomized trials initiated preconception: Lessons learned from the EAGeR Trial. Paediatric Perinat Epidemiol 2015;Feb 14.doi:10.1111/ppe.12177.

Mumford SL, Silver RM, Sjaarda LA, Wactawski-Wende J, Townsend JM, Lynch AM, Galai N, Lesher LL, Faraggi D, Perkins NJ, Schliep KC, Zarek SM, Schisterman EF. Expanded findings from a randomized controlled trial of preconception low dose aspirin and pregnancy loss. Hum Reprod 2016;31:657-65.
Radin RG, Mumford SL, Silver RM, Lesher LL, Galai N, Faraggi D, Wactawski-Wende J, Townsend JM, Lynch AM, Simhan HN, Sjaarda LA, Perkins NJ, Zarek SM, Schliep KC, Schisterman EF. Pre-conception low-dose aspirin and sex ratio in the EAGeR trial. J Clin Invest 2015;125:3619-26.

Zarek SM, Mitchell EM, Sjaarda LA, Mumford SL, Silver RM, Stanford JB, Galai N, Schliep KC, Radin RG, Plowden TC, DeCherney AH, Schsiterman EF. Anti-mulleriam hormone and pregnancy loss from the EAGER trial. Fertil Steril 2016; 105:946-52. e2. Doi:10.1016/j.fertnstert.2015.12.003.

Ahrens K, Silver RM, Mumford SL, Sjaarda LA, Perkins NJ, Wactawski-Wende J, Galai N, Townsend JM, Lynch AM, Lesher LL, Faraggi D, Zarek S, Schisterman EF. Complications and safety of preconception low dose aspirin among women with prior pregnancy losses. Obstet Gynecol 2016; 127:689-98.

Sjaarda LA, Radin RG, Silver RM, Mitchell E, Mumford SL, Wilcox B, Galai N, Perkins NJ, Wactawski-Wende J, Stanford JB, Schisterman EF. Low dose aspirin restores diminished pregnancy and live birth rates in women with low grade inflammation: A secondary analysis of a randomized trial. J Clin End Met 2016;102:1495-1504.

Agrawala S, Sjaarda LA, Omosigho UR, Perkins NJ, Silver RM, Mumford SL, Connell MT, Naimi AI, Halvoson LM, Schisterman EF. Effects of preconception low dose aspirin on pregnancy and live birth according to socioeconomic status: a secondary analysis of a randomized clinical trial. In revision, PLoS One.

Pregnancy Loss Related Publications

Heuser C, Eller A, Warren J, Branch DW, Salmon J, Silver RM. A case-control study of membrane-cofactor protein mutations in two populations of patients with pregnancy loss. J Reprod Immunol 2011;91:71-5.
Romero ST, Giersbach KB, Paxton CN, Rose NC, Schisterman EF, Branch DW, Silver RM. Differentiation of genetic abnormalities in early pregnancy loss. Ultraound Obstet Gynecol 2014;doi:10.1002/uog.14713.

Hinkle SN, Mumford SL, Schisterman EF, Silver RM, Mitchell EM, Sjaarda LA, Radin RG, Perkins NJ, Galai N, Grantz KL. A prospective analysis of nausea and vomiting during pregnancy and its relation to pregnancy loss. JAMA Internal Med, 2016;doi:10:1001/jamaintmed.2016.5641.

Plowden T, Schisterman EF, Sjaarda LA, Perkins NJ, Silver RM, Radin R, Kim K, Galai N, DeCherney AH, Mumford SL. Thyroid stimulating hormone, anti-thyroid antibodies and pregnancy outcomes. In press, Am J Obstet Gynecol.

Gibbins KJ, Sjaarda LA, Branch DW, Mumford SL, Perkins NJ, Schisterman EF, Silver RM. Preconception antiphospholipid antibodies and risk of subsequent pregnancy early pregnancy loss. Lupus 2018; doi: 10.1177/0961203318776089.

Mumford SL, Garbose RA, Kim K, Kuhr DL, Omosigho UR, Perkins NJ, Galai N, Silver RM, Sjaarda LA, Plowden TC, Schisterman EF. Association of preconception serum 25-hydroxyvitamin D concentrations with live birth and pregnancy loss: a prospective cohort study. Lancet Diabetes Endocrinol 2018; S2213-8587(18)30153-0.doi:10.1016/S2213-8587(18)30153-0.

Yeung EH, Park H, Nobles C, Mumford SL, Silver RM, Schisterman EF. Cardiovascular disease family history and risk of pregnancy loss: a prospective study. Submitted, Fertil Steril.

Recurrent Pregnancy Loss Related Publications

Coulam CB, Clark DA, Beer AE, Kutteh WH, Silver RM, Kwak J, Stephenson M. Current clinical options for diagnosis and treatment of recurrent spontaneous abortion. Am J Reprod Immunol 1997;38:57-74.

Esplin MS, Branch DW, Silver RM, Stagnaro-Green A. Thyroid autoantibodies are not associated with recurrent pregnancy loss. Am J Obstet Gynecol 1998;179:1583-6.

Lee RM, Emlen W, Scott JR, Branch DW, Silver RM. Anti-beta-2-glycoprotein-I antibodies in women with recurrent spontaneous abortion, unexplained fetal death and antiphospholipid syndrome. Am J Obstet Gynecol 1999; 181:642-8.

Lee RM, Branch DW, Silver RM. Immunoglobulin A anti-beta-2-glycoprotein antibodies in women who experience unexplained recurrent spontaneous abortion and unexplained fetal death. Am J Obstet Gynecol 2001;185:748-53.

Sullivan AE, Silver RM, LaCoursiere DY, Porter TF, Branch DW. Does recurrent aneuploidy contribute to recurrent miscarriage? Obstet Gynecol 2004;10:784-8.

Sullivan AE, Nelson L, Silver RM, Frias AE, Porter TF, Branch DW. The aryl hydrocarbon receptor nuclear translocator gene polymorphism inpatients with recurrent miscarriage. Am J Reprod Immunol 2006;55:51-3.

Heuser C, Dalton J, McPherson C, Branch DW, Porter TF, Silver RM. Idiopathic recurrent pregnancy loss recurs at similar gestational ages. Am J Obstet Gynecol 2010;203:343-5.

Eller AG, Porter TF, Nelson L, Branch DW, Silver RM. Vascular endothelial growth factor polymorphsims in women with recurrent pregnancy loss. Am J Reprod Immunol 2010;Oct 24.Epub.

Branch DW, Gibson M, Silver RM. Recurrent miscarriage. N Engl J Med.2010:363:1740-7.
Chin J, Heuser C, Eller E, Branch DW, Silver RM. Leptin and leptin receptor single nucleotide polymorphisms and recurrent pregnancy loss. J Perinatol 2013;33:589-92.

Sharshiner R, Romero ST, Bardsley TR, Branch DW, Silver RM. Celiac disease serum markers and recurrent pregnancy loss. J Reprod Immunol 2013;100:104-8.

Romero ST, Sharshiner M, Stoddard GJ, Branch DW, Silver RM. Correlation of serum fructosamine and recurrent pregnancy loss. J Obstet Gynecol Res 2016; 42:763-8. doi:10.1111/jog.12974 Epub.

Radin RG, Mumford SL, Sjaarda LA, Silver RM, Wactawski-Wende J, Lynch AM, Perkins NJ, Wilcox BD, Hinkle SN, Plowden TC, Kim K, Schisterman EF. Recent attempted and actual weight change in relation to pregnancy loss: a prospective cohort study. BJOG 2017;doi:10.1111/1471-0528.14859.

Kim K, Schisterman EF, Silver RM, Wilcox BD, Lynch AM, Perkins NJ, Browne R W , Lesher L, Stanford JB, Ye A, Wactawski-Wende J, Mumford S. Shorter time to pregnancy with increasing preconception carotene concentrations among women with 1 to 2 previous pregnancy losses. Am J Epidemiol 2018;doi:10.1093/aje/kwy101.

Kim K, Schisterman EF, Silver RM, Wilcox BD, Lynch AM, Perkins NJ, Browne RW, Lesher LL, Stanford JB, Ye A, Wactawski-Wende J, Mumford SL. Shorter time to pregnancy with increasing preconception carotene concentrations among women with 1 to 2 previous pregnancy losses. Am J Epidemiol 2018; doi: 10.1093/aje/kwy101.

Sullivan AE, Silver RM, LaCoursiere DY, Porter TF, Branch DW. (2004). Recurrent fetal aneuploidy and recurrent miscarriage. Obstet Gynecol, 104(4), 784-8.

Carrell DT, Wilcox AL, Lowy L, Peterson CM, Jones KP, Erickson L, Campbell B, Branch DW, Hatasaka HH. (2003). Elevated sperm chromosome aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss. Obstet Gynecol, 101(6), 1229-35.

Sullivan AE, Lewis T, Stephenson M, Odem R, Schreiber J, Ober C, Branch DW. (2003). Pregnancy outcome in recurrent miscarriage patients with skewed X chromosome inactivation. Obstet Gynecol, 101(6), 1236-42.

Dizon-Townson DS, Kinney S, Branch DW, Ward K. (1997). The factor V Leiden mutation is not a common cause of recurrent miscarriage. J Reprod Immunol, 34(3), 217-23.

Dizon-Townson D, Nelson L, Scott JR, Branch DW, Ward K. (1995). Human leukocyte antigen DQ alpha sharing is not increased in couples with recurrent miscarriage. Am J Reprod Immunol, 34(4), 209-12.

Rote NS, Dostal-Johnson D, Branch DW. (1990). Antiphospholipid antibodies and recurrent pregnancy loss: correlation between the activated partial thromboplastin time and antibodies against phosphatidylserine and cardiolipin. Am J Obstet Gynecol, 163(2), 575-84.

Scott JR, Branch DW, Kochenour NK, Ward K. (1988). Intravenous immunoglobulin treatment of pregnant patients with recurrent pregnancy loss caused by antiphospholipid antibodies and Rh immunization. Am J Obstet Gynecol, 159(5), 1055-6.

Stillbirth Related Publications

Silver RM, Varner MV, Reddy U, Goldenberg R, Pinar H, Conway D, Bukowski R, Carpenter M, Hogue C, Willinger M, Dudley D, Saade G, Stoll B. Work-up of stillbirth: a review of the evidence. Am J Obstet Gynecol, 2007;196:433-44..

Reddy UM, Goldenberg R, Silver R, Smith GCS, Pauli RM, Wapner RJ, et al. Stillbirth classification: developing an international consensus for research: Executive summary of NICHD workshop. Obstet Gynecol 2009;114:901-14.

Heuser C, Hossain S, Silver RM, Varner MV. Non-anomalous stillbirth by gestational age: trends differ based on method of epidemiologic calculation. J Maternal-Fetal Neonatal Med, 2009. Epub Nov 3.
Heuser C, Hunn J, Varner M, Hossain S, Vered S, Silver RM. Discrepancies between stillbirth birth certificates and medical records. Obstet Gynecol 2010;116:1296-301.

Parker CB, Hogue CJR, Koch MA, Willinger M, Reddy U, Thorsten VR, Dudley DJ, Silver RM, Coustan D, Saade GR, Conway D, Varner MW, Stoll B, Pinar H, Bukowski R, Carprenter M, Goldenberg R, for the Stillbirth Collaborative Research Network. Stillbirth Collaborative Research Network: Design, methods and recruitment experience. Paediatric and Perinatal Epidemiology 2011;25:425-35.

The Stillbirth Collaborative Research Network Writing group – corresponding author RM Silver. (Radek Bukowski, MD; Marshall Carpenter MD;; Deborah Conway, MD; Donald Coustan, MD; Donald J. Dudley, MD; MD; Matthew A. Koch, MD, PhD; Robert Goldenberg, MD; Carol J. Rowland Hogue, PhD; Corette B. Parker, DrPH; Halit Pinar, MD; Uma M. Reddy, MD, MPH; George R. Saade, MD; Robert M. Silver, MD; Barbara Stoll, MD; Michael W. Varner, MD; Marian Willinger PhD). Causes of death among stillbirths. JAMA 2011;306:2459-68.

The Stillbirth Collaborative Research Network Writing group (Radek Bukowski, MD; Marshall Carpenter MD;; Deborah Conway, MD; Donald Coustan, MD; Donald J. Dudley, MD; MD; Matthew A. Koch, MD, PhD; Robert Goldenberg, MD; Carol J. Rowland Hogue, PhD; Corette B. Parker, DrPH; Halit Pinar, MD; Uma M. Reddy, MD, MPH; George R. Saade, MD; Robert M. Silver, MD; Barbara Stoll, MD; Michael W. Varner, MD; Marian Willinger PhD). Association between stillbirth and risk factors known at pregnancy confirmation. JAMA 2011;306:2469-79.

Reddy UM, Page GP, Saade GR, Silver RM, Thorsten VR, Parker CB, Pinar H, Willinger M, Stoll BJ, Heim-Hall J, Varner MW, Goldenberg R, Bukowski R, Wapner RJ, Drews-Botsch CD, O’Brien B, Dudley DJ, Levy B, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Stillbirth Collaborative Research Network (SCRN). Genetic abnormalities in stillbirth: comparison of karyotype and microarray testing. N Engl J Med 2012;367:2185-93.

Hogue CJR, Bann C, Willinger M, Temple J, Parker P, Silver RM, Dudley DJ, Koch M, Coustan D, Stoll BJ, Reddy UM, Saade G, Conway D, Varner MW, Goldenberg RL. A population-based case-control study of stillbirths: the relationship of significant life events to the racial disparity for African Americans. Am J Epidemiol 2013;177:755-67.

Heuser CC, McFadden M, Hammer A, Varner MV, Silver RM. Stillbirth gestational age as a predictor of recurrence risk. A J Perinatol 2013;Aug 5 Epub.

Silver RM, Parker CB, Reddy UM, Goldenberg RL, Coustan C, Dudley DJ, Saade GR, Stoll B, Koch MA, Conway D, Bukowski R, Hogue CJR, Pinar H, Moore J, Willinger M, Branch DW. Anticardiolipin and anti-beta-2-glycoprotein-1 antibodies in a multicenter, population-based case-control study of stillbirth. Obstet Gynecol 2013;122:641-58.

Hogue CJR, Parker CB, Willinger M, Temple JR, Bann CM, Silver RM, Dudley DJ, Moore JL, Coustan DR, Stoll BJ, reddy UM, Varner MW, Saade GR, Conway D, Goldenberg RL, for the Eunice Kennedy Shriver National Institute of Child Health and Development Stillbirth Collaborative Research Network Writing Group. The association of stillbirth with depression 3 – 6 months post-delivery. Paeadiatr Perinat Epidemiol 2015;29:131-43.

Silver RM, Parker CB, Goldenberg RL, Reddy UM, Dudley DJ, Saade GR, Hogue CJR, Coustan D, Koch MA, Conway D, Bukowski R, Pinar H, Varner MV, Stoll B, Moore J, Willinger M. Bile acids in a multi-center, population-based case-control study of stillbirth. Am J Obstet Gynecol 2013 Nov 8 Epub.

Varner MV, Silver RM, Hogue CJR, Willinger M, parker CB, Thorsten VR, Goldenberg RL, Saade GR, Dudley DJ, Coustan D, Stoll B, Bukowski R, Koch MA, Conway D, Pinar H, Reddy U. Association between stillbirth and illicit drug use and smoking during pregnancy. Obstet Gynecol 2014; 123:113-25.

Bukowski R, Hansen NI, Willinger M, Reddy UM, Parker CB, Pinar H, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL for the Eunice Kennedy Shriver national Institute of Child Health and Development (NICHD) Stillbirth Collaborative Research Network (SCRN). Fetal growth and stillbirth: a population based study. PLoS Med 2014;11:e1001633.

Pinar H, Goldenberg RL, Koch MA, Heim-Hall J, Hawkins H, Shehata B, Abramowsky C, Parker CB, Dudley DJ, Silver RM, Stoll B, Carpenter M, Saade G, Moore J, Conway D, Varner MW, Hogue CJR, Coustan DR, Sbrana E, Thorston V, Willinger M, Reddy UM. Placental findings in singleton stillbirths: A case-control study. Obstet Gynecol 2014;123:325-36.

Flenady V, Wojcieszek AM, Middleton P, Elwood D, Erwich JJ, Smith G, Lawn JE, Blencowe H, Khong Y, Silver RM, Boyle FM, Coory M, Leisher SH, Reinebrant H, Gross MM, Horey D, Farrales L, Bloomfield F, McCowan L, Brown S, Joseph KS, Zeitlin J, Ravaldi C, Vannacci A, Cassidy J, Siassakos D, Heazell A, Storey C, Farquar C, Sadler L, Petersen S, Froen JF, Goldenberg RL. Stillbirth: A renewed case for action in high income countries. Lancet 2016; 387:691-702. http://dx.doi.org/10/1016/S0140-6736(15)01020.

Gibbins KJ, Silver RM, Pinar H, Reddy U, Parker C, Thorsten V, Willinger M, Dudley DJ, Saade GR, Coustan D, Koch M, Conway D, Hogue C, Stoll B, Goldenberg RL. Hypertensive disorders of pregnancy, stillbirth and placental pathology. Placenta 2016;43:61-8.

MacDorman MF, Reddy UM, Silver RM. Trends in stillbirth by gestational age, United States, 2006 – 2012. Obstet Gynecol, 2015;126:1146-50.

Silver RM, Saade G, Thorsten V, Parker CB, Reddy UM, Drewes-Botsch C, Conway D, Coustan D, Dudley DJ, Bukowski R, Hogue CJR, Pinar H, Varner MW, Goldenberg RL. Thrombophilias and stillbirth: The Stillbirth Collaborative Research Network. Am J Obstet Gynecol 2016 Apr 27. Pii:S0002-9378(16)30104-1. Doi: 10.1016/j.ajog.2016.04.026 [Epub ahead of print].

Wojcieszek AM, Boyle FM, Cassidy J, Cassidy P, Erwich JJ, Farrales L, Gross MM, Heazell AEP, Leisher SH, Mills T, Murphy M, Pettersson K, Ravaldi C, Ruidiaz J, Silver RM, Storey C, Vannacci A, Middleton P, Ellwood D, Flenady V. Care in subsequent pregnancies following stillbirth: An international survey of parents. BJOG 2016 Nov 30.doi: 10.1111/1471-0528.14424 [epub ahead of print].

Freedman AA, Cammack AL, Temple JR, Silver RM, Dudley DJ, Stoll BJ, Varner MW, Saade GR, Conway D, Goldenberg RL, Hogue CJ. Maternal exposure to childhood maltreatment and risk of stillbirth. Annals Epidemiol 2017;pii:S047-2797(17)30191-6.doi:10.106/j.annepidem.2017.07.001.

Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Hogue CJR, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM. Evaluation for stillbirth: Stillbirth Collaborative Research Network. Obstet Gynecol 2017;129:699-706.

Boyle A, Preslar JP, Hogue CJR, Silver RM, Reddy UM, Goldenberg RL, Stoll BJ, Varner MW, Conway DL, Saade GR, Bukowski R, Dudley DJ. Route of delivery in women with stillbirth. Obstet Gynecol 2017;129:693-8.

Wocjcieszek AM, Shepherd E, Middleton P, Gardener G, Ellwood DA, McClure EM, Gold KJ, Khong TY, Silver RM, Erwich JJHM, Flenady V. Interventions for investigating and identifying the causes of stillbirth. Cochrane Database of Systematic Reviews 2018 Apr 30;4:CD012504. DOI: 10.1002/14651858.CDO12504.

Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL. Altered fetal growth, placental abnormalities, and stillbirth. PLoS One 2017;12:e0182874.doi:10.1371/journal.pone.0182874.ecollection 2017.

Forsberg K, Christiansen-Lindquist L, Silver RM. Factors associated with stillbirth autopsy in Georgia and Utah, 2010-2014. Am J Perinatol 2018; doi:10.1055/s-0038-1648234.

Page JM, Thorsten V, Reddy UM, Dudley DJ, Hogue CJR, Saade GR, Pinar H, Parker CB, Conway D, Stoll BJ, Coustan D, Bukowski R, Varner MW, Goldenberg RL, Gibbins K, Silver RM. Potentially preventable stillbirth in a diverse U.S. cohort. Obstet Gynecol 2018;doi:10.1097/AOG.0000000000000002421.

Gibbons KJ, Reddy UM, Saade GR, Goldenberg RL, Dudley DJ, Parker CB, Thorsten V, Pinar H, Bukowski R, Hogue CJ, Silver RM. Smith-Lemli-Opitz Mutations in Unexplained Stillbirths. Am J Perinatol 2018;doi:10.1055/s-0038-1626705.

Kim K, Browne RW, Nobles CJ, Radin RG, Holland TL, Omosigho UR, Connell MT, Plowden TC, Wilcox BD, Silver RM, Perkins NJ, Schisterman EF, Nichols CM, Kuhr DL, Sjaarda LA, Mumford SL. Harrison MS, Thorsten VR, Dudley DJ, Parker CB, Koch MA, Hogue CJR, Stoll BJ, Silver RM, Varner MW, Pinar HM, Coustan DR, Saade GR, Bukowski RK, Conway DL, Willinger M, Reddy UM, Goldenberg RL. Stillbirth, inflammatory markers, and obesity: Results from the Stillbirth Collaborative Research Network. Am J Perinatol 2018; doi.org/10.1055/s-0038-1639340.

MClure EM, Saleem S, Gouder SS, Dhaded S, Guruprasad G, Kumar Y, Tikmani SS, Kadir M, Raza J, Yasmin H, Moore JL, Kim J, Bann C, Parlberg L, Aceituno A, Carlo WA, Silver RM, Lambert L, Patterson J, Goldenberg RL. The project to understand and research preterm pregnancy outcomes and stillbirths in South Asia (PURPOSe): a protocol of a prospective cohort study of causes of mortality among preterm births and stillbirths. Reprod Health 2018;15:89.doi:10.1186/s12978-018-0528-1.

Angley M, Thorsten VR, Drews-Botsch C, Dudley DJ, Gldenberg RL, Silver RM, Stoll BJ, Pinar H, Hogue CJR. Association of participation in a supplemental nutrition program with stillbirth by race, ethnicity, and maternal characteristics. BMC Pregnancy Childbirth 2018;18:306.doi:1186/s12884-018-1920-0.

Wojcieszek AM, Shepherd E, Middleton P, Lassi ZS, Wilson T, Murphy MM, Heazell AE, Ellwood DA, Silver RM, Flenady V. care prior to and during subsequent pregnancies following stillbirth for improving outcomes. Cochrane Database Syst Rev 2018:CD012203.doi:10.1002/14651858.CD012203.pub2.

Gibbins KJ, Pinar H, Reddy UM, Saade GR, Goldenerg RL, Dudley DJ, Drews-Botsch C, Freedman AA, Daniels LM, Parker CB, Throsten V, Bukowski R, Silver RM. Findings in stillbirths associated with placental disease. Am J Perinatol 2019;may14.doi:10.1055/s-0039-1688472.

Gupta PM, Freedman AA, Kramer MR, Goldenberg RL, Willinger M, Stoll BJ, Silver RM, Dudley DJ, Parker CB, Hogue CJR. Interpregnancy interval and risk of stillbirth: a population-based case control study. Ann Epidemiol 2019; May 11.pii:S1047-2797(18)30815-9.doi:10.1016/j.annepidem.2019.05-001.

Wojcieszek AM, Heazell AEP, Middleton P, Ellwood D, Silver RM, Flenady V. Research priorities and potential methodologies to inform care in subsequeant pregnancies following stillbirth: a web based survey of healthcare professionals, researchers and advocates. BMJ Open 2019;9:e028735.doi:10.1136/bmjopen-2018-028735.

Eller AG, Branch DW, Byrne JL. (2006). Stillbirth at Term. Obstet Gynecol, 108(2), 442-447.
Aagaard-Tillery KM, Holmgren C, Lacoursiere DY, Houssain S, Bloebaum L, Satterfield R, Branch DW, Varner MW. (2006). Factors associated with nonanomalous stillbirths: the Utah Stillbirth Database 1992-2002. Am J Obstet Gynecol, 194(3), 849-54.

Misc. Publications

Wegmann TG, Athanassakis I, Guilbert L, Branch D, Dy M, Menu E, Chaouat G. (1989). The role of M-CSF and GM-CSF in fostering placental growth, fetal growth, and fetal survival. Transplant Proc, 21(1 Pt 1), 566-8.

Palomba S, Santagni S, Gibbins K, La Sala GB, Silver RM. Pregnancy complications in spontaneous and assisted conceptions of women with infertility and factors of subfertility. A comprehensive review. Reprod Biomed Online 2016; S1472-6483(16)30455-2.

Kowalik A, Vichin M, Liu HC, Branch DW, Berkeley AS. (1997). Midfollicular anticardiolipin and antiphosphatigylserine antibody titers do not correlate with in vitro fertilization outcome. Fertil Steril, 68, 298-304.

Esplin MS, Fausett MB, Peltier MR, Hamblin S, Silver RM, Branch DW, Adashi EY, Whiting D. (2005). The use of cDNA microarray to identify differentially expressed labor-associated genes within the human myometrium during labor. Am J Obstet Gynecol, 193(2), 404-13.

Coulam CB, Branch DW, Clark DA, Gleicher N, Kutteh W, Lockshin MD, Rote NS. (1999). American Society for Reproductive Immunology report of the Committee for Establishing Criteria for Diagnosis of Reproductive Autoimmune Syndrome. Am J Reprod Immunol, 41(2), 121-32.

Warren JE, Silver RM, Nelson L, Dalton J, Porter TF, Branch DW. Cervical insufficiency: a genetic condition? Collagen 1α1 intron SP1 and transforming growth factor-β ARG-25-PRO polymorphisms in women with cervical insufficiency. Obstet Gynecol 2007;110:619-24.

Warren JE, Nelson L, Esplin MS, Silver RM. Interleukin-10 polymorphisms and cervical insufficiency. Am J Obstet Gynecol 2009;201:372-4.

Branch DW. (1986). Operations for cervical incompetence. Clin Obstet Gynecol, 29(2), 240-54.
Weis JJ, Yang L, Seiler KP, Silver RM. Pathological manifestations in murine Lyme disease: Association with tissue invasion and spirochete persistence. Clin Infect Dis 1997;25:S18-24..

Lee RM, Brown MA, Branch DW, Ward K, Silver RM. Anticardiolipin and anti-beta-2-glycoprotein-I antibodies in preeclampsia. Obstet Gynecol 2003;102:294-300.

Branch DW, Mitchell MD, Miller E, Palinski W, Witztum JL. (1994). Pre-eclampsia and serum antibodies to oxidised low-density lipoprotein. Lancet, 343(8898), 645-6.

Branch DW, Dudley DJ, LaMarche S, Mitchell MD. (1992). Sera from preeclamptic patients contain factor(s) that stimulate prostacyclin production by human endothelial cells. Prostaglandins Leukot Essent Fatty Acids, 45(3), 191-5.

Branch DW, Dudley DJ, Mitchell MD. (1991). Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia. Lancet, 337(8747), 943-5.

Rote NS, Lau RJ, Harrison MR, Branch DW, Scott JR. (1987). Platelet-binding immunoglobulins in pregnancy-induced hypertension. I. Platelet-associated IgM on fetal platelets: evidence of a fetal autoimmune reaction? J Reprod Immunol, 10(4), 261-72.

Esplin MS, Peltier MR, Hamblin S, Smith S, Fausett MB, Dildy GA, Branch DW, Silver RM, Adashi EY. (2005). Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor. Placenta, 26(8-9), 661-71.

Dudley DJ, Branch DW, Edwin SS, Mitchell MD. (1996). Induction of preterm birth in mice by RU486. Biol Reprod, 55(5), 992-5.

Dudley DJ, Chen CL, Branch DW, Hammond E, Mitchell MD. (1993). A murine model of preterm labor: inflammatory mediators regulate the production of prostaglandin E2 and interleukin-6 by murine decidua. Biol Reprod, 48(1), 33-9.

Faucett MB, Vogtlander M, Lee RM, Rodgers GM, Branch DW, Silver RM. Heparin induced thrombocytopenia is rare in pregnancy. Am J Obstet Gynecol 2001;185:148-52.

Fausett MB, Vogtlander M, Lee RM, Esplin MS, Branch DW, Rodgers GM, Silver RM. (2001). Heparin-induced thrombocytopenia is rare in pregnancy. Am J Obstet Gynecol, 185(1), 148-52.

Silver RM, Porter TF, Branch DW, Esplin MS, Scott JR. (2000). Neonatal alloimmune thrombocytopenia: antenatal management. Am J Obstet Gynecol, 182(5), 1233-8.

Silver RM, Branch DW, Scott JR. (1995). Maternal thrombocytopenia in pregnancy: time for a reassessment. Am J Obstet Gynecol, 173(2), 479-82.

Rodger MA, Hague WM, Kingdom J, Kahn SR, Karovitch A, Sermer M, Clement AM, Coat S, Chan WS, Said J, Rey E, Robinson S, Khurana R, Demers C, Kovacs MJ, Solymoss S, Hinshaw K, Dwyer J, Smith G, McDonald S, Newstead-Angel J, Mcleod A, Khandelwal M, Silver RM, Le Gal G, Greer I, Keely E, Rosene-Montela K, Walker M, Wells PS for the TIPPS investigators. The thrombophilia in pregnancy prophylaxis study (TIPPS): a multi-national randomized trial of antepartum dalteparin compared with no antepartum dalteparin for the prevention of pregnancy complications in pregnant thrombophilic women. Lancet 2014 Jul 24. Pii:S0140-6736(14)60793-5.Epub.