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International Head and Neck Cancer Epidemiology Consortium (INHANCE)

The In ternational H ead and N eck C ancer E pidemiology (INHANCE) Consortium is a collaboration of research groups leading large molecular epidemiology studies of head and neck cancer (oral cavity, oropharynx, hypopharynx and larynx).

Questionnaire data on over 26,600 cases & 37,900 controls, and biological samples from a majority of the study population were collected. These studies have been conducted in various regions of the world.  More details.

We aim to improve the understanding of the causes and mechanisms of head and neck cancer.


Inhance meeting group 2022
INHANCE meeting on zoom, September 16, 2022


INHANCE Recent Publications

Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE ConsortiumGoyal N, Hennessy M, Lehman E, Lin W, Agudo A, Ahrens W, Boccia S, Brennan P, Brenner H, Cadoni G, Canova C, Chen C, Conway D, Curado MP, Dal Maso L, Daudt AW, Edefonti V, Fabianova E, Fernandez L, Franceschi S, Garavello W, Gillison M, Hayes RB, Healy C, Herrero R, Holcatova I, Kanda JL, Kelsey K, Hansen BT, Koifman R, Lagiou P, La Vecchia C, Levi F, Li G, Lissowska J, Mendoza López R, Luce D, Macfarlane G, Mates D, Matsuo K, McClean M, Menezes A, Menvielle G, Morgenstern H, Moysich K, Negri E, Olshan AF, Pandics T, Polesel J, Purdue M, Radoi L, Ramroth H, Richiardi L, Schantz S, Schwartz SM, Serraino D, Shangina O, Smith E, Sturgis EM, Świątkowska B, Thomson P, Vaughan TL, Vilensky M, Winn DM, Wunsch-Filho V, Yu GP, Zevallos JP, Zhang ZF, Zheng T, Znaor A, Boffetta P, Hashibe M, Lee YA, Muscat JE. Oral Dis. 2022 Mar 24. doi: 10.1111/odi.14196. Epub ahead of print. PMID: 35322907.

Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancerGiraldi L, Collatuzzo G, Hashim D, Franceschi S, Herrero R, Chen C, Schwartz SM, Smith E, Kelsey K, McClean M, Gillison M, Boccia S, Hashibe M, Amy Lee YC, Boffetta P. Cancer Epidemiol. 2021 Dec;75:102020. doi: 10.1016/j.canep.2021.102020. Epub 2021 Sep 9. PMID: 34509873.

Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE ConsortiumConway DI, Hovanec J, Ahrens W, Ross A, Holcatova I, Lagiou P, Serraino D, Canova C, Richiardi L, Healy C, Kjaerheim K, Macfarlane GJ, Thomson P, Agudo A, Znaor A, Brennan P, Luce D, Menvielle G, Stucker I, Benhamou S, Ramroth H, Boffetta P, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt A, Koifman R, Wunsch-Filho V, Yuan-Chin AL, Hashibe M, Behrens T, McMahon AD. J Epidemiol Community Health. 2021 Aug;75(8):779-787. doi: 10.1136/jech-2020-214913. Epub 2021 Feb 23. PMID: 33622804; PMCID: PMC8292575.

Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer. Bravi F, Lee YA, Hashibe M, Boffetta P, Conway DI, Ferraroni M, La Vecchia C, Edefonti V; INHANCE Consortium investigators. Oral Dis. 2021 Jan;27(1):73-93. doi: 10.1111/odi.13502. Epub 2020 Jul 16. PMID: 32569410; PMCID: PMC7752834.

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. Di Credico G, Polesel J, Dal Maso L, Pauli F, Torelli N, Luce D, Radoi L, Matsuo K, Serraino D, Brennan P, Holcatova I, Ahrens W, Lagiou P, Canova C, Richiardi L, Healy CM, Kjaerheim K, Conway DI, Macfarlane GJ, Thomson P, Agudo A, Znaor A, Franceschi S, Herrero R, Toporcov TN, Moyses RA, Muscat J, Negri E, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt AW, Koifman R, Wunsch-Filho V, Olshan AF, Zevallos JP, Sturgis EM, Li G, Levi F, Zhang ZF, Morgenstern H, Smith E, Lazarus P, La Vecchia C, Garavello W, Chen C, Schwartz SM, Zheng T, Vaughan TL, Kelsey K, McClean M, Benhamou S, Hayes RB, Purdue MP, Gillison M, Schantz S, Yu GP, Chuang SC, Boffetta P, Hashibe M, Yuan-Chin AL, Edefonti V. Br J Cancer. 2020 Oct;123(9):1456-1463. doi: 10.1038/s41416-020-01031-z. Epub 2020 Aug 24. PMID: 32830199.