School of Medicine

International Head and Neck Cancer Epidemiology Consortium

International Head and Neck Cancer Epidemiology Consortium

The In ternational H ead and N eck C ancer E pidemiology (INHANCE) Consortium is a collaboration of research groups leading large molecular epidemiology studies of head and neck cancer (oral cavity, oropharynx, hypopharynx and larynx).

Questionnaire data on over 26,600 cases & 37,900 controls, and biological samples from a majority of the study population were collected. These studies have been conducted in various regions of the world. Please click here for the details.

We aim to improve the understanding of the causes and mechanisms of head and neck cancer.

2021 INHANCE meeting on Zoom (May 11, 2021)

(INHANCE meeting on zoom, May 11, 2021)


INHANCE Recent Publications

Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer. Giraldi L, Collatuzzo G, Hashim D, Franceschi S, Herrero R, Chen C, Schwartz SM, Smith E, Kelsey K, McClean M, Gillison M, Boccia S, Hashibe M, Amy Lee YC, Boffetta P. Cancer Epidemiol. 2021 Sep 9;75:102020. doi: 10.1016/j.canep.2021.102020. Epub ahead of print. PMID: 34509873.

Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium. Conway DI, Hovanec J, Ahrens W, Ross A, Holcatova I, Lagiou P, Serraino D, Canova C, Richiardi L, Healy C, Kjaerheim K, Macfarlane GJ, Thomson P, Agudo A, Znaor A, Brennan P, Luce D, Menvielle G, Stucker I, Benhamou S, Ramroth H, Boffetta P, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt A, Koifman R, Wunsch-Filho V, Yuan-Chin AL, Hashibe M, Behrens T, McMahon AD. J Epidemiol Community Health. 2021 Feb 23:jech-2020-214913. doi: 10.1136/jech-2020-214913. Epub ahead of print. PMID: 33622804.

Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer. Bravi F, Lee YA, Hashibe M, Boffetta P, Conway DI, Ferraroni M, La Vecchia C, Edefonti V; INHANCE Consortium investigators. Oral Dis. 2021 Jan;27(1):73-93. doi: 10.1111/odi.13502. Epub 2020 Jul 16. PMID: 32569410; PMCID: PMC7752834.

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. Di Credico G, Polesel J, Dal Maso L, Pauli F, Torelli N, Luce D, Radoi L, Matsuo K, Serraino D, Brennan P, Holcatova I, Ahrens W, Lagiou P, Canova C, Richiardi L, Healy CM, Kjaerheim K, Conway DI, Macfarlane GJ, Thomson P, Agudo A, Znaor A, Franceschi S, Herrero R, Toporcov TN, Moyses RA, Muscat J, Negri E, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt AW, Koifman R, Wunsch-Filho V, Olshan AF, Zevallos JP, Sturgis EM, Li G, Levi F, Zhang ZF, Morgenstern H, Smith E, Lazarus P, La Vecchia C, Garavello W, Chen C, Schwartz SM, Zheng T, Vaughan TL, Kelsey K, McClean M, Benhamou S, Hayes RB, Purdue MP, Gillison M, Schantz S, Yu GP, Chuang SC, Boffetta P, Hashibe M, Yuan-Chin AL, Edefonti V. Br J Cancer. 2020 Oct;123(9):1456-1463. doi: 10.1038/s41416-020-01031-z. Epub 2020 Aug 24. PMID: 32830199

Risk Prediction Models for Head and Neck Cancer in the US Population From the INHANCE Consortium. Lee YA, Al-Temimi M, Ying J, Muscat J, Olshan AF, Zevallos JP, Winn DM, Li G, Sturgis EM, Morgenstern H, Zhang ZF, Smith E, Kelsey K, McClean M, Vaughan TL, Lazarus P, Chen C, Schwartz SM, Gillison M, Schantz S, Yu GP, D'Souza G, Gross N, Monroe M, Kim J, Boffetta P, Hashibe M. Am J Epidemiol. 2020 Apr 2;189(4):330-342. doi: 10.1093/aje/kwz259. PMID: 31781743