SCIENTIFIC POSTERS
Sunday, April 14
8:00 a.m. MT
Topic: Prevalence and Significance of Multiple Hypercoagulable Conditions in Cerebral Venous Thrombosis: 12 years of Experience in a Referral Center
Presenter: Ahmad Al-Awwad, MD (presenter); Ahmer Asif, MD; David Lee Gordon, MD, FAHA, FAAN; Linda A. Hershey, MD, PhD, FAAN; Veronica Astrid Moreno Gomez, MD; Zainab Al Obaidi, MD; Chao Xu; Calin I. Prodan, MD
Summary: Despite the prevalence of hypercoagulable conditions in patients with cerebral vein thrombosis (CVT), they do not predict CVT severity, although they remain crucial for establishing etiology and determining treatment duration.
8:00 a.m. MT
Topic: Pediatric to Adult MS Transition Practices in the US
Presenter: Aaron Wachtenheim Abrams, MD (presenter); Skyler Peterson; Jonathan Race, PhD; Akash Virupakshaiah, MD; Kimberly O'Neill, MD; Claudia Gambrah-Lyles, MD; Kristen Fisher, DO; Soe Soe Mar, MD, FAAN; Emmanuelle Waubant, MD, PhD, FAAN; Moses Rodriguez, MD, FAAN; Jan-Mendelt Tillema, MD; Teri Schreiner, MD, MPH, FAAN; Mary R. Rensel, MD, FAAN; Tanuja Chitnis, MD, FAAN; Lauren B. Krupp, MD, FAAN; Timothy E. Lotze, MD, FAAN; Theron Charles Casper, PhD; Yolanda Wheeler; Jayne Ness, MD; Mark Gorman, MD; Leslie A. Benson, MD; John W. Rose, MD, FAAN
Summary: There is significant variability in the transition practices from pediatric to adult multiple sclerosis (MS) care across ten major pediatric MS centers in the US, highlighting the need for standardized protocols and improved support for patients and families during this critical period.
8:00 a.m. MT
Topic: The Effectiveness of Neurologic Telehealth Outpatient Care During the COVID-19 Pandemic
Presenter: Chloe Electra Hill, MD; Chun Chieh Lin, PhD; Ellen Anderson-benge; Christine Doss Esper, MD, FAAN, FANA; Kavita Nair, PhD, FAAN; Adam De Havenon, MD; Neil A. Busis, MD, FAAN; Gregory J. Esper, MD, MBA, FAAN; Brian Callaghan, MD, MS, FAAN
Summary: Telehealth neurologic evaluations show comparable follow-up clinic visit rates to in-person visits, with potential differences in emergency room visits, suggesting overall adequacy in care delivery, though further investigation by diagnosis is warranted.
11:45 a.m. MT
Topic: The Evolution of a Multiple Sclerosis Relapse: Analysis of Clinical & Patient-reported Outcome Measures
Presenter: Justin Abbatemarco, MD (presenter); Carol Swetlik, MD; Daniel Ontaneda, MD, PhD, FAAN; Robert A. Bermel, MD; Sarah Marie Planchon Pope, PhD, CCRP; Scott Husak; Brittany Lapin; Yadi Li; Deborah M. Miller, PhD
Summary: The study examines changes in functional and patient-reported outcome measures (PROMs) after a multiple sclerosis (MS) relapse, revealing that while performance outcomes remain similar, patients with a recent relapse exhibit poorer PROMs compared to those without relapse, underscoring the broad impact of relapse on various symptoms.
11:45 a.m. MT
Topic: Development of eIF2B Activator ABBV-CLS-7262 as a Novel Treatment for Vanishing White Matter Disease
Presenter: Amos Baruch, PhD (presenter); Paul Ravi Malik, PhD; ANU GOPATHI, MBBS; Ellen Ingalla; Matthew Rosebraugh, PhD; Yi Rang Han, PhD; Emmanuelle Bellemin; Adrian Serone, PhD; Steven Fausch, PhD; Jyoti Somayaji Asundi, Jr., Other; Ganesh Kolumam, PhD; Chunlian Zhang; Jose Luis Zavala-Solorio, Other; Diana L. Donnelly-Roberts, PhD; Malleswari Challagundla, PhD; Christina Boch; Charlie Cao, PhD; Eric G. Mohler, PhD; Carmela Sidrauski, PhD; Joshua Bonkowsky, MD, PhD; Anna Jeong, MD; Bill Cho, MD, PhD
Summary: The study outlines the scientific rationale and clinical approach for testing ABBV-CLS-7262, an eIF2B activator, as a novel therapy for Vanishing White Matter (VWM) disease, supported by preclinical evidence and Phase 1 data in healthy volunteers, with a Phase 1b/2 study underway in participants with VWM disease to assess safety, tolerability, and pharmacodynamics.
11:45 a.m. MT
Topic: Epigenetic Age and Brain Health Events: Findings from the Health and Retirement Study
Presenter: Cyprien Rivier, MD (presenter); Natalia Szejko, MD, PhD; Daniela Brenda Renedo, MD; Adam De Havenon, MD; Kevin N. Sheth, MD, FAAN; Thomas Gill; Guido Jose Falcone, MD
Summary: The study demonstrates a reciprocal relationship between brain health events (BHE) and epigenetic age acceleration, with both a history of BHE associated with older epigenetic age and epigenetic age acceleration linked to higher risk of BHE, findings supported by Mendelian Randomization (MR) analyses, underscoring the importance of nuanced biological age assessment in neurological research, with epigenetic clocks offering promise in this regard.
11:45 a.m. MT
Topic: Life’s Essential 8 and Brain Health Clinical Outcomes in Middle-aged Adults
Presenter: Santiago Clocchiatti-Tuozzo (presenter); Cyprien Rivier, MD; Daniela Brenda Renedo, MD; Shufan Huo, MD, PhD; Victor Manuel Torres-Lopez, MA; Adam De Havenon, MD; Kevin N. Sheth, MD, FAAN; Thomas Gill; Guido Jose Falcone, MD
Summary: The study aimed to investigate the relationship between cardiovascular health in middle age, assessed by the American Heart Association’s Life’s Essential 8 (LE8) tool, and the risk of stroke, dementia, or late-life depression (LLD) later in life, finding that poorer cardiovascular health was significantly associated with a higher risk of these conditions, suggesting the potential utility of this endpoint in brain health-focused clinical trials.
5:30 p.m. MT
Topic: Diagnostic Challenges of Lyme Neuroborreliosis in Inpatient Neurology: A Case Series
Presenter: Kaitlyn Palmer, MD (presenter); Maria Sokola, MD; Sanem Pinar Uysal, MD; Jessica Cooperrider, MD; Anthony K. Leung, DO; Alejandro Torres-Trejo, MD; Yuebing Li, MD, PhD, FAAN; Justin Abbatemarco, MD
Summary: The study highlights the diagnostic challenges of Lyme neuroborreliosis (LNB) and underscores the importance of increasing awareness among clinicians to prompt timely treatment and management, particularly in traditionally low-incidence areas where cases may be underrecognized due to unfamiliarity with its unique clinical manifestations.
5:30 p.m. MT
Topic: Epilepsy Folklore Belief Is Prevalent in Hispanic Patients with Epilepsy, but Lack of Insurance Is a Bigger Barrier to Care
Presenter: Amanda Elizabeth Simon, MD (presenter); Michelle Miranda, PhD; Angela Yvonne Peters, MD
Summary: Belief in epilepsy folklore is prevalent among Hispanic patients with epilepsy, but it does not seem to significantly delay seeking care, with lack of health insurance identified as a primary barrier to accessing neurologic care in this population.
5:30 p.m. MT
Topic: Kelch-like Protein-11 Encephalitis Case Report
Presenter: Stefanie Jordan Rodenbeck, MD (presenter); Chelsea Schmoll, DO; Katrina Collins, MD
Summary: This poster highlights a case report of a 44-year-old male with Kelch-like Protein-11 Encephalitis (KLHL11 encephalitis), a rare neurological disorder associated with testicular germ cell tumors, characterized by debilitating symptoms and refractory response to immunotherapy, despite aggressive treatment.
5:30 p.m. MT
Topic: Disparities in Healthcare Interactions After Intracerebral Hemorrhage: Evidence from the REDUCE Trial
Presenter: Julia Zabinska (presenter); Christopher Laurence Taylor; Emma Sylvaine Peasley; Dheeraj Devkrishin Lalwani; Anna Schwartz, Other; Guido Jose Falcone, MD; Lauren Hachmann Sansing, MD; Rohan Arora, MD; Carlos Mena-Hurtado, MD; Adam De Havenon, MD; Munachi Nkiru Okpala, NP; Cheryl Bushnell, MD, MHS; Michael T. Mullen, MD; Jordana Cohen; Debbie Cohen; Steven R. Messe, MD, FAAN, FAHA; Rachel Forman, MD; Kevin N. Sheth, MD, FAAN
Summary: A preliminary analysis of post-stroke healthcare interactions for intracerebral hemorrhage (ICH) survivors from the REDUCE trial reveals that African American patients are less likely to engage with the healthcare system after discharge, emphasizing the necessity for targeted support in navigating post-stroke care for this demographic.
5:30 p.m. MT
Topic: Enhanced Benefits of the Life’s Essential 8 in APOE Epsilon 4 Carriers
Presenter: Santiago Clocchiatti-Tuozzo (presenter); Cyprien Rivier, MD; Daniela Brenda Renedo, MD; Shufan Huo, MD, PhD; Victor Manuel Torres-Lopez, MA; Adam De Havenon, MD; Kevin N. Sheth, MD, FAAN; Thomas Gill; Guido Jose Falcone, MD
Summary: Middle-aged APOE ε4 carriers without a history of vascular events derive greater neuro- and cardiovascular benefits from adhering to the American Heart Association's Life’s Essential 8 (LE8), suggesting tailored interventions could improve long-term outcomes for this at-risk population.
5:30 p.m. MT
Topic: Prognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group
Presenter: Ethan Y. Wang (presenter); Shubham Misra, PhD; Jennifer Yan, Other; Pei Yi Chook, MBBS; Yuki Kawamura; Rachel Kitagawa, Other; Jennifer A. Kim, MD; Emily Jean Gilmore, MD; Adam De Havenon, MD; Adithya Sivaraju, MD; Lawrence J. Hirsch, MD, FAAN; Guido Jose Falcone, MD; Lauren Hachmann Sansing, MD; Jessica Magid-Bernstein, MD, PhD; Nishant Kumar Mishra, MD, MBBS, PhD, FESO
Summary: Lower levels of C-C motif chemokine ligand-2 (CCL2) predict poor outcomes one year post-stroke, while no inflammatory biomarker was associated with post-stroke seizure risk, indicating the necessity for prospective studies on the temporal profile of inflammatory biomarkers in post-stroke seizure risk.
Monday, April 15
11:45 a.m. MT
Topic: Describe the Clinical Course, Diagnostic Approach and Outcomes Following Thymectomy in Four Non-myasthenic Patients with Synaptic Antibody-mediated Autoimmune Neurologic Disease
Presenter: Aditi Sharma, MBBS (presenter); Tammy L. Smith, MD, PhD; Melissa Ann Wright, MD; Ka-Ho Wong; M. Mateo Paz Soldan, MD, PhD; John W. Rose, MD, FAAN; Jonathan Ross Galli, MD; Robert Kadish, MD; Stacey Clardy, MD, PhD, FAAN
Summary: Thymectomy led to clinical improvement and disease stabilization in four non-myasthenic patients with synaptic antibody-mediated autoimmune neurologic disease, suggesting its potential therapeutic benefit in such cases where conventional immunotherapy may be insufficient or contraindicated.
11:45 a.m. MT
Topic: Safety of Discontinuing Disease-modifying Therapy in Aging MS Patients: A Single-center Study
Presenter: Cori Polonski, MD (presenter); Ka-Ho Wong; Trieste Francis; John W. Rose, MD, FAAN
Summary: Discontinuation of injectable disease-modifying therapies (DMT) in aging patients with relapsing-remitting Multiple Sclerosis (RRMS) appears safe, as evidenced by stability in clinical metrics and preliminary optical coherence tomography (OCT) measurements suggesting no significant change in total macular volume (TMV) post-discontinuation.
11:45 a.m. MT
Topic: Healthcare Utilization Barriers in Multiple Sclerosis Patients Transitioning from Adolescent to Adult Care: A Multi-institutional Database Analysis in the United States
Presenter: Trieste Francis (presenter); Ka-Ho Wong; Heewon Hwang; Melissa Ann Wright, MD; John W. Rose, MD, FAAN
Summary: The study aims to explore healthcare utilization trends and identify potential barriers faced by young adults with multiple sclerosis (MS) using data from TriNetX, revealing initial findings that only 38% of MS patients in the dataset are prescribed disease-modifying therapies, with further analysis underway to investigate DMT use and clinical visit frequency.
5:30 p.m. MT
Topic: Effect of Levodopa on Blood Pressure and Baroreflex Function in Parkinson's Disease
Presenter: Timi Earl (presenter); Amani Jridi; Perla C. Thulin, MD; Meghan Zorn, PA; Kathleen McKee, MD; Kristin Elle Mitrovich, MD; Paolo M. Moretti, MD; Jumana Tariq A Alshaikh, MD; Panagiotis Kassavetis, MD; Melissa M. Cortez, DO; Guillaume Lamotte, MD
Summary: This prospective study explores the impact of levodopa on blood pressure and baroreflex function in individuals with Parkinson's disease, revealing its association with hypotension in both those with and without neurogenic orthostatic hypotension (OH) and suggesting a potential role in unmasking autonomic dysfunction and contributing to delayed OH.
5:30 p.m. MT
Topic: Orthostatic Headache and Cardiovascular Adrenergic Responses During Valsalva Maneuver in Children and Adolescents with Postural Tachycardia Syndrome
Presenter: Luke Heyliger, MD (presenter); Melissa M. Cortez, DO
Summary: Physiologic differences observed during autonomic reflex screen testing, particularly in cardiovascular adrenergic responses during Valsalva, suggest a potential link between altered cardiovascular function and orthostatic headache in young patients with postural orthostatic tachycardia syndrome (POTS).
Tuesday, April 16
8:00 a.m. MT
Topic: Unraveling the Earliest Phases of Vascular Cognitive Impairment and Dementia by Establishing a Large USA CADASIL Consortium
Presenter: Michael D. Geschwind, MD, PhD, FAAN (presenter); Jose Biller, MD, FAAN, FACP, FAHA; Jamie Elliott, MD, PhD; Suman Jayadev, MD; Stephen P. Salloway, MD, MS; Jose Gutierrez, MD; Sudha Seshadri, MD, FAAN; Jennifer J. Majersik, MD, FAAN; Karen Dianne Orjuela, MD, FAAN; David S. Liebeskind, MD, FAAN; Helmi L. Lutsep, MD, FAAN; Ihab Hajjar; Fanny Mojdeh Elahi, MD; Henry Jeremy Bockholt; Jane S. Paulsen, PhD
Summary: This study aims to characterize the clinical progression and identify biomarkers in presymptomatic to early/moderate symptomatic NOTCH3 carriers of CADASIL, utilizing a longitudinal cohort across 12 USA sites to inform future treatment trials and improve understanding and management of vascular dementias.
8:00 a.m. MT
Topic: Characterization of Social Determinants of Health in Patients with Anti-NMDAR Encephalitis
Presenter: Ka-Ho Wong (presenter); Sarah Shapiro; Erena Tonee Clah Kolb; Riya Amit Soneji; Abigail Hailey Sorenson; Melissa Ann Wright, MD; Trieste Francis; Tammy L. Smith, MD, PhD; Stacey Clardy, MD, PhD, FAAN
Summary: Patients with anti-NMDAR encephalitis, often from socioeconomically disadvantaged backgrounds, exhibit various social determinants of health (SDOH) challenges, with ongoing research aimed at delineating these factors to improve diagnostic timeliness and inform targeted interventions.
8:00 a.m. MT
Topic: ECT in NMDAR Encephalitis: A Retrospective Cohort and Systematic Review of Literature
Presenter: Melissa Ann Wright, MD (presenter); Mar Guasp, MD; Christian Lachner; Gregory S. Day, MD, MSc, FAAN; Grace Gombolay, MD; Maarten Jan Titulaer, MD, PhD; Stacey Clardy, MD, PhD, FAAN
Summary: Electroconvulsive therapy (ECT) in patients with anti-NMDAR encephalitis (NMDARE) shows mixed outcomes with limited evidence supporting its efficacy, highlighting the need for caution and further research due to potential risks and confounding factors.
8:00 a.m. MT
Topic: Seizures in the Leukodystrophies
Presenter: Ashley Nicole Hackett, MD (presenter); Katie Liu; Helena Yan; Camille Sierra Corre, MD; Kerry Gao, Other; Daniel Conor Kelly; Gabrielle T. Ghabash; Jordan Goodman; William Benko, MD; Robert Ian Thompson-Stone, MD, FAAN; Seyed Ali Fatemi, MD, MBA; Gerald Raymond, MD; Stephanie Keller, MD; Florian Eichler, MD; Maria Escolar; Joshua Bonkowsky, MD, PhD; Eric James Mallack, MD
Summary: Seizures are prevalent in 29% of pediatric patients with leukodystrophies, with age, focal slowing, and generalized epileptiform discharges being significant predictors, while lacosamide and levetiracetam are identified as effective antiseizure medications in this population.
11:45 a.m. MT
Topic: Predictive Value of Clinical, Cerebrospinal Fluid, & Vessel Wall MRI Variables in Diagnosing Primary Angiitis of the CNS
Presenter: Aaron Shoskes, DO (presenter); Abbas Kharal, MD; Sidonie Elie Ibrikji, MD; Youssef Farag; Matthew Kiczek; Richa Sheth; Muhammad Shazam Hussain, MD
Summary: The study investigates diagnostic predictors for Primary Angiitis of the Central Nervous System (PACNS) using clinical, cerebrospinal fluid (CSF), and quantitative vessel-wall magnetic resonance imaging (VWMRI) markers, finding that encephalopathy, seizure, headache, CSF pleocytosis, and specific VWMRI metrics are significantly associated with PACNS diagnosis.
11:45 a.m. MT
Topic: Conjugal Synucleinopathies: A Clinicopathologic Study
Presenter: Shannon Chiu, MD (presenter); Charles H. Adler, MD, PhD, FAAN; Matthew J. Halverson; Nan Zhang; Holly A. Shill, MD, FAAN; Erika Driver-Dunckley, MD, FAAN; Shyamal Mehta, MD, PhD, FAAN; Alireza Atri, MD, PhD; John N. Caviness, MD, FAAN; Geidy Serrano; David Shprecher, DO, FAAN; Christine Belden; Marwan N. Sabbagh, MD, FAAN; Kathy Ellen Long; Thomas Beach
Summary: The study aimed to investigate the presence of synucleinopathies in conjugal couples through neuropathological analysis, revealing that while some couples showed synucleinopathy alignment, the rarity of such occurrences suggests limited transmission between spouses.
5:30 p.m. MT
Topic: Relapses in Neurosarcoidosis: Analysis of Disease Recurrence from a Single Center Cohort
Presenter: Aditi Sharma, MBBS; Ka-Ho Wong; Tammy L. Smith, MD, PhD; Melissa Ann Wright, MD; Jennifer Lord, MD; M. Mateo Paz Soldan, MD, PhD; Robert Kadish, MD; Jonathan Ross Galli, MD; John W. Rose, MD, FAAN; Stacey Clardy, MD, PhD, FAAN
Summary: This study examines disease relapses in neurosarcoidosis within a cohort from the University of Utah Healthcare System, highlighting the need for evidence-based guidelines on immunotherapy selection and treatment duration in this complex condition.
5:30 p.m. MT
Topic: LAMA2 Mutation Presenting as Leukodystrophy and Cancer: Case Series
Presenter: Shreya Rajesh Goyalpatel, Other (presenter); Neelam Goyal, MD; May Han, MD; Jacinda B. Sampson, MD, PhD
Summary: Two sisters with no neuromuscular symptoms but multiple cancers exhibit an atypical, autosomal dominant leukodystrophy associated with a novel LAMA2 gene mutation, shedding light on the diverse presentations of LAMA2-related disorders.
Wednesday, April 17
8:00 a.m. MT
Topic: Improving Rural Stroke Processes - A Trainee-driven Approach
Presenter: Mandi Ellgen, MD (presenter); Kristena Hunsaker, RN; Stephanie Lyden, MD; Thomas M. Buchanan, MD; Yao He, MS; Lee Shan Chung, MD; Jennifer J. Majersik, MD, FAAN
Summary: In this rural telestroke initiative, a neurology resident led the implementation of acute stroke protocols, resulting in increased utilization of critical CT angiography (CTA) for detecting large vessel occlusions (LVOs), highlighting the potential for trainees to address resource deficiencies in underserved areas.
8:00 a.m. MT
Topic: Isolated Optic Neuritis: Etiology, Characteristics, and Outcomes in a Large Single-center Cohort
Presenter: Yoji Hoshina, MD (presenter); Meagan Dawn Seay, DO: Ka-Ho Wong; Sravanthi Vegunta, MD; Melissa Ann Wright, MD; Tammy L. Smith, MD, PhD; Stacey Clardy, MD, PhD, FAAN
Summary: This study evaluates demographic, clinical, and outcome data in patients with isolated optic neuritis (ON), revealing a high prevalence of AQP4-IgG and MOG-IgG negativity despite recent testing advances, highlighting the importance of recognizing clinical features for prognosis and treatment in this population.
8:00 a.m. MT
Topic: Antibodies to Ha, Ks, and Zo: Frequency and Characteristics of Antibody-positive Patients in an Unselected Cohort
Presenter: Kyphuong Luong, PhD (presenter); Tammy L. Smith, MD, PhD; Lisa Kay Peterson, PhD
Summary: The study investigates the frequency and clinical characteristics of Ha, Ks, and Zo antibodies in anti-synthetase syndrome (ASyS) patients, utilizing a line immunoblot assay (LIA) to detect these antibodies, highlighting its importance for diagnosis and disease management.
8:00 a.m. MT
Topic: Evaluating Sleep Apnea Risk in Survivors of Intracerebral Hemorrhage in the REDUCE Cohort
Presenter: Emma Sylvaine Peasley (presenter); Jacqueline Geer, MD; Julia Zabinska; Rachel Forman, MD; Dheeraj Devkrishin Lalwani; Anna Schwartz, Other; Guido Jose Falcone, MD; Lauren Hachmann Sansing, MD; Rohan Arora, MD; Carlos Mena-Hurtado, MD; Adam De Havenon, MD; Munachi Nkiru Okpala, NP; Cheryl Bushnell, MD, MHS; Michael T. Mullen, MD; Jordana Cohen; Debbie Cohen; Steven R. Messe, MD, FAAN, FAHA; Kevin N. Sheth, MD, FAAN
Summary: The study conducted an exploratory analysis within the REDUCE trial, finding that Hispanic survivors of intracerebral hemorrhage (ICH) were more likely to be at high risk for obstructive sleep apnea (OSA) compared to non-Hispanic survivors, suggesting a potential association that warrants further investigation in larger cohorts.
11:45 a.m. MT
Topic: Depression and Anxiety in Neuromyelitis Optica Spectrum Disease (NMOSD): Analysis of a National Dataset
Presenter: Esther Zeng (presenter); Abigail Hailey Sorenson; Tammy L. Smith, MD, PhD; Melissa Ann Wright, MD; Aditi Sharma, MD; Trieste Francis; John W. Rose, MD, FAAN; Ka-Ho Wong; Stacey Clardy, MD, PhD, FAAN
Summary: This study reveals that depression and anxiety are prevalent in approximately two-fifths of NMOSD patients, with over half diagnosed before their NMOSD confirmation, emphasizing the importance of vigilance in screening for mental health issues during patient visits.
11:45 a.m. MT
Topic: Frequency of Neuromyelitis Optica Spectrum Disorder Correlated Symptoms: A Pre- and Post-diagnosis Comparison from a National Dataset
Presenter: Abigail Hailey Sorenson (presenter); Esther Zeng; Tammy L. Smith, MD, PhD; Melissa Ann Wright, MD; Aditi Sharma, MD; Trieste Francis; John W. Rose, MD, FAAN; Ka-Ho Wong; Stacey Clardy, MD, PhD, FAAN
Summary: This study utilizing the TriNetX database highlights the common symptom diagnoses of neuromyelitis optica spectrum disease (NMOSD) both pre- and post-diagnosis, emphasizing the importance of understanding the clinical presentation and longitudinal follow-up of NMOSD patients.
11:45 a.m. MT
Topic: Indirect Treatment Comparison of Ravulizumab Versus Approved Treatment Options for Adults with Aquaporin-4 Immunoglobulin G-Positive (AQP4-IgG+) Neuromyelitis Optica Spectrum Disorder (NMOSD)
Presenter: Stacey Clardy, MD, PhD, FAAN (presenter); Sean J. Pittock, MD; Orhan Aktas, MD; Jin Nakahara, MD, PhD; Noriko Isobe, MD; Diego Centonze; Sami Fam; Adrian Kielhorn; Jeffrey Yu, PhD; Jeroen Paul Jansen, PhD; Ina Zhang
Summary: In adult patients with AQP4-IgG+ NMOSD, ravulizumab demonstrates superior efficacy compared to satralizumab and inebilizumab as monotherapy, while showing comparable efficacy to eculizumab, and when used in combination with immunosuppressants, ravulizumab remains more effective than satralizumab and comparable to eculizumab.
11:45 a.m. MT
Topic: NMOSD Patients Transitioning from Adolescent to Adult Care: A Multi-institutional Database Analysis in the United States
Presenter: Melissa Ann Wright, MD; Ka-Ho Wong; Trieste Francis; Abigail Hailey Sorenson; John W. Rose, MD, FAAN; Tammy L. Smith, MD, PhD; Stacey Clardy, MD, PhD, FAAN
Summary: In a national cohort of young patients with Neuromyelitis Optica Spectrum Disorder (NMOSD), healthcare utilization trends reveal potential barriers and social determinants of health, highlighting the vulnerability of this population to inconsistent treatment and emphasizing the importance of addressing these challenges for optimizing long-term outcomes during transitions of care.
11:45 a.m. MT
Topic: Post-COVID Hemicrania Continua: A Case Report
Presenter: Sara Zeccardi, NP (presenter); Katherine Dorfman; Seniha N. Ozudogru, MD
Summary: The poster presents a unique case of new-onset hemicrania continua headache following COVID-19 infection, highlighting the diverse spectrum of post-COVID headaches and emphasizing the importance of considering hemicrania continua in the differential diagnosis, while also advocating for the development of diagnostic criteria for post-COVID headaches.
11:45 a.m. MT
Topic: Different Response to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage
Presenter: Maximiliano Alberto Hawkes, MD (presenter); Santiago Clocchiatti-Tuozzo; Cyprien Rivier, MD; Adnan I. Qureshi, MD; Charles Matouk; Nils Petersen, MD; Adam De Havenon, MD; Kevin N. Sheth, MD, FAAN; Guido Jose Falcone, MD
Summary: Intensive blood pressure reduction reduces hematoma expansion in deep intracerebral hemorrhages but increases the risk of renal adverse events, highlighting divergent responses between deep and lobar hemorrhages and underscoring the necessity for deeper biological insights for tailored therapeutic strategies.
5:30 p.m. MT
Topic: Comparison of Depression and Anxiety in Neuromyelitis Optica Spectrum Disease and Multiple Sclerosis Patients: Analysis of Two National Datasets
Presenter: Abigail Hailey Sorenson (presenter); Esther Zeng; Heewon Hwang; Tammy L. Smith, MD, PhD; Melissa Ann Wright, MD; Aditi Sharma, MD; Trieste Francis; John W. Rose, MD, FAAN; Ka-Ho Wong; Stacey Clardy, MD, PhD, FAAN
Summary: Patients diagnosed with multiple sclerosis (MS) exhibit higher rates of depression and anxiety diagnoses compared to those diagnosed with neuromyelitis optica spectrum disease (NMOSD), suggesting potential differences in mental health symptomatology or screening practices between the two conditions.
5:30 p.m. MT
Topic: NMOSD: Previously Seropositive Patient Presents with Seronegative Brainstem Attack
Presenter: Drew Weber, MD (presenter); John W. Rose, MD, FAAN; L Dana DeWitt, MD
Summary: In a patient initially diagnosed with seropositive neuromyelitis optica spectrum disorder (NMOSD) who later became seronegative, a brainstem attack occurred despite the absence of detectable aquaporin-4 antibodies, prompting questions about the natural fluctuation of antibody presence and potential mechanisms underlying seronegative attacks.
5:30 p.m. MT
Topic: Evaluating the Use and Efficacy of Avonex and Plegridy in Pediatric Patients
Presenter: Melissa Ann Wright, MD (presenter); Bradley Barney, PhD; Skyler Peterson; Michael Waltz; John W. Rose, MD, FAAN; Mary R. Rensel, MD, FAAN; Aaron Wachtenheim Abrams, MD; Emmanuelle Waubant, MD, PhD, FAAN; Yolanda Wheeler; Moses Rodriguez, MD, FAAN; Jan-Mendelt Tillema, MD; Lauren B. Krupp, MD, FAAN; Mark Gorman, MD; Leslie A. Benson, MD; Timothy E. Lotze, MD, FAAN; Nikita Shukla, MD; Soe Soe Mar, MD, FAAN; Tanuja Chitnis, MD, FAAN; Teri Schreiner, MD, MPH, FAAN; Megan Vignos, PhD; Jonathan Planton, PharmD, BCGP; Theron Charles Casper, PhD
Summary: The study aimed to summarize the demographic, clinical characteristics, and efficacy outcomes of pediatric-onset multiple sclerosis (POMS) patients treated with Avonex or Plegridy, revealing that the data from the registry align with previously reported effects of these therapies in adults with MS.
5:30 p.m. MT
Topic: A Novel Mouse Model of Cerebral Demyelination in X-linked Adrenoleukodystrophy Highlights NLRP3 Activation in Lesion Pathogenesis
Presenter: Ezzat Hashemi, PhD (presenter); Isha Srivastava, MD, PhD; Alejandro Aguirre; Ezra Yoseph; Esha Kaushal, PhD; Avni Awani; Jae Kyu Ryu, PhD; Shahrzad Talebian; Pauline Chu; Lawrence Steinman, MD, FAAN; Paul Orchard; Troy Lund; May Han, MD; Joshua Bonkowsky, MD, PhD; Keith Van Haren, MD
Summary: The poster presents the creation and characterization of a novel mouse model of X-linked adrenoleukodystrophy (ALD), demonstrating similarities between the mouse model and human cALD lesions, suggesting its utility in studying disease mechanisms and potential therapeutic targets.
5:30 p.m. MT
Topic: Fast Track Neurology Headache Clinic for Pregnant Patients: Is It Doable or Needed?
Presenter: Sara Zeccardi, NP (presenter); Seniha N. Ozudogru, MD
Summary: The poster outlines a program aimed at reducing wait times and increasing satisfaction for pregnant patients experiencing headaches by implementing a nurse practitioner-led headache care initiative, resulting in improved patient satisfaction and decreased wait times, with plans for ongoing assessment of provider satisfaction and program refinement.