SCIENTIFIC PLATFORM SESSIONS
Sunday, April 14
2:36 p.m. MT
Topic: Increased Risk of Suicidal Ideation in Patients with Spinocerebellar Ataxias
Presenter: Levi Peppel (presenter); Ruo-Yah Lai; Puneet Opal, MD, PhD; Jeremy D. Schmahmann, MD, FAAN; Christopher Gomez, MD, PhD; Henry L. Paulson, MD, PhD, FAAN; Theresa A. Zesiewicz, MD; Susan L. Perlman, MD; George R. Wilmot, MD, PhD; Sarah H. Ying, MD; Chiadi Uchendu Onyike, MD; K O. Bushara, MBBS, FRCP; Michael D. Geschwind, MD, PhD, FAAN; Karla Patricia Figueroa; Stefan M. Pulst, MD, FAAN; S H. Subramony, MBBS, FAAN; Antoine Duquette, MD; Tetsuo Ashizawa, MD, FAAN; Ali G. Hamedani, MD, MHS; Marie Ynez Davis, MD, PhD; Sharan Srinivasan, MD; Matthew Robert Burns, MD, PhD; Lauren Moore, PhD; Vikram Shakkottai, MD, PhD; Liana Rosenthal, MD; Sheng-Han Kuo, MD; Chi-Ying (Roy) Lin, MD, FAAN
Summary: This study reveals a higher prevalence of suicidal ideation in individuals with spinocerebellar ataxias (SCAs) compared to the general population, particularly prominent in SCA3 cases, emphasizing the importance of including suicidal risk screening as part of the clinical assessment for SCAs.
2:36 p.m. MT
Topic: Neuropathological Profile of Cases with Mild Cognitive Impairment
Presenter: Andrew Hiep Ho, DO (presenter); Parichita Choudhury, MD; Charles H. Adler, MD, PhD, FAAN; David Shprecher, DO, FAAN; Shyamal Mehta, MD, PhD, FAAN; Holly A. Shill, MD, FAAN; Erika Driver-Dunckley, MD, FAAN; Christine Belden; Geidy Serrano; Thomas Beach; Alireza Atri, MD, PhD; Cecilia Tremblay, PhD
Summary: This presentation aims to characterize the neuropathological heterogeneity in mild cognitive impairment (MCI), revealing associations between vascular pathology and both amnestic and non-amnestic MCI subtypes, as well as differences in white matter rarefaction and Lewy bodies among multidomain MCI cases.
3:30 p.m. MT
Topic: Polygenic Resistance to Blood Pressure Treatment and Stroke Risk
Presenter: Shufan Huo, MD, PhD (presenter); Cyprien Rivier, MD; Santiago Clocchiatti-Tuozzo; Daniela Brenda Renedo, MD; Hongyu Zhao, PhD; Adam De Havenon, MD; Kevin N. Sheth, MD, FAAN; Guido Jose Falcone, MD
Summary: This study examines the impact of polygenic predisposition to hypertension on blood pressure treatment response and stroke risk in primary prevention, revealing that individuals with higher genetic predisposition have an increased risk of resistant hypertension and stroke, suggesting the need for personalized interventions targeting high-risk subjects.
3:30 p.m. MT
Topic: Predictors of a Relapsing Course in Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease
Presenter: Akash Virupakshaiah, MD (presenter); Vinicius Andreoli Schoeps, MD; Jonathan Race, PhD; Michael Waltz; Siefaddeen Sharayah, MD; Zahra Nasr, MD; Carson Moseley, MD, PhD; Scott S. Zamvil, MD, PhD, FAAN; Cristina Maria Gaudioso, MD; Allison Schuette; Theron Charles Casper, PhD; John W. Rose, MD, FAAN; Eoin P. Flanagan, MBBCh, FAAN; Moses Rodriguez, MD, FAAN; Jan-Mendelt Tillema, MD; Tanuja Chitnis, MD, FAAN; Mark Gorman, MD; Jennifer Graves, MD, PhD; Leslie A. Benson, MD; Mary R. Rensel, MD, FAAN; Aaron Wachtenheim Abrams, MD; Lauren B. Krupp, MD, FAAN; Timothy E. Lotze, MD, FAAN; Gregory S. Aaen, MD; Yolanda Wheeler; Teri Schreiner, MD, MPH, FAAN; Amy T. Waldman, MD; Janet Chong; Soe Soe Mar, MD, FAAN; Emmanuelle Waubant, MD, PhD, FAAN
Summary: This study identifies female sex, Hispanic/Latino ethnicity, and initiation of maintenance treatment with anti-CD20 agents or intravenous immunoglobulin shortly after onset as factors associated with a lower risk of relapse in pediatric patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), emphasizing the importance of early intervention strategies for those at higher risk of recurrence.
Monday, April 15
11:15 a.m. MT
Topic: Safety and Outcomes of Intravenous Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage within the Florida Stroke Registry
Presenter: Aaron Shoskes, DO (presenter); Lili Zhou; Hao Ying, PhD, Other; Hannah Gardener, ScD; Ayham Alkachroum; Ruijie Yin, PhD; Gillian L. Gordon-Perue, MD, FAAN; Antonio Bustillo; Sebastian Koch, MD; Erika Tatiana Marulanda-Londono, MD; Carolina Gutierrez; Tatjana Rundek, MD, PhD; Jose Gabriel Romano, MD, FAAN; Jennifer J. Majersik, MD, FAAN; Veronica Astrid Moreno Gomez, MD; Negar Asdaghi, MD
Summary: This study examines the safety of intravenous thrombolysis (IVT) in ischemic stroke patients with prior intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH), revealing a more than tripled risk of symptomatic hemorrhage in this population, highlighting the importance of cautious clinical consideration and further research in this area.
11:27 a.m. MT
Topic: Brain Health Outcomes in Sexual and Gender Minority Groups
Presenter: Shufan Huo, MD, PhD (presenter); Cyprien Rivier, MD; Santiago Clocchiatti-Tuozzo; Daniela Brenda Renedo, MD; N. Abimbola Sunmonu, MD, PhD; Adam De Havenon, MD; Kevin N. Sheth, MD, FAAN; Guido Jose Falcone, MD
Summary: This study investigates the risk of adverse brain health outcomes among sexual and gender minority (SGM) individuals compared to cisgender heterosexual individuals, revealing that SGM groups have higher odds of stroke, dementia, and late-life depression, highlighting the need for inclusive and diverse neurological care.
4:54 p.m. MT
Topic: Risk and Onset Latency of Incident (New-onset) Epilepsy After Stroke in Post-9/11 U.S. Veterans: A Post-hoc Analysis of the Long-term Impact of Military-relevant Brain Injury Consortium (LIMBIC-CENC) Study Data
Presenter: Manaz Rezayee (presenter); Jacqueline Hirschey, MD; Megan Amuan; Zulfi Haneef, MD, MBBS, MRCP, FAAN; Linda S. Williams, MD, FAAN; Ian Stewart; Elisabeth Wilde, PhD; Eamonn Kennedy, PhD; Marissa Kellogg, MD, MPH; Mary Jo Pugh, PhD, RN, FAAN
Summary: This study finds that approximately 10% of post-9/11 Veterans who experience strokes develop epilepsy, with half developing epilepsy within 9.5 months of stroke and 25% experiencing onset after prolonged latencies exceeding 3 years.
Tuesday, April 16
1:24 p.m. MT
Topic: Quantitative Assessment of Reperfusion Impact on Cerebral Edema and Functional Outcomes in Large-vessel Occlusion Stroke Patients
Presenter: Madelynne Olexa (presenter); Yelyzaveta Begunova; Rajat Dhar, MD; Charles Matouk; Kevin N. Sheth, MD, FAAN; Santiago Ortega Gutierrez, MD; Adam De Havenon, MD; Nils Petersen, MD
Summary: This study investigates the relationship between reperfusion and cerebral edema after endovascular thrombectomy for large-vessel occlusion stroke, revealing that successful reperfusion is linked with decreased edema markers and improved functional outcomes, highlighting the importance of reperfusion in stroke management.
1:36 p.m. MT
Topic: Exploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage
Presenter: Madelynne Olexa (presenter); Yelyzaveta Begunova; Emily Jean Gilmore, MD; Jennifer A. Kim, MD; Alison Herman; Rachel Beekman, MD; Jessica Magid-Bernstein, MD, PhD; Charles Matouk; Kevin N. Sheth, MD, FAAN; Eliza Cushman Miller, MD; Santiago Ortega Gutierrez, MD; Adam De Havenon, MD; Lauren Hachmann Sansing, MD; Nils Petersen, MD
Summary: This study explores the relationship between cerebrospinal fluid interleukin-6 (IL-6) levels and cerebral autoregulation in aneurysmal subarachnoid hemorrhage (aSAH) patients, suggesting a potential association between IL-6 levels and impaired autoregulation, highlighting the need for further research to refine management strategies for improved outcomes.
Wednesday, April 17
1:00 p.m. MT
Topic: Nine-year Trends in Payments for Disease Modifying Therapies in Multiple Sclerosis and Autoimmune Neurological Related Disorders in Medicare Part D
Presenter: Ka-Ho Wong (presenter); Erica Marini; Trieste Francis; Robert Kadish, MD; Jonathan Ross Galli, MD; M. Mateo Paz Soldan, MD, PhD; Julia Klein, NP; Abigail Hailey Sorenson; Jordan King, Other; John W. Rose, MD, FAAN; Tammy L. Smith, MD, PhD; Stacey Clardy, MD, PhD, FAAN
Summary: This presentation examines the escalating costs of disease-modifying therapies (DMTs) for multiple sclerosis (MS) and autoimmune neurological-related disorders (ANRD) in Medicare Part D from 2013 to 2021, highlighting a significant increase in both claims and payments, particularly for infusible medications, suggesting the need for legislative measures to alleviate the burden on the Centers for Medicare and Medicaid Services (CMS) budget.
1:36 p.m. MT
Topic: Evaluation of Glial Fibrillary Acidic Protein (GFAP) and Neurofilament Light Chain (NfL) Levels During Eculizumab and Ravulizumab Treatments in Aquaporin-4-Positive (AQP4+) Neuromyelitis Optica Spectrum Disorder (NMOSD)
Presenter: Dean M. Wingerchuk, MD, FAAN (presenter); Jeffrey L. Bennett, MD, PhD, FAAN; Achim Berthele; Stacey Clardy, MD, PhD, FAAN; Ho Jin Kim, MD; Jin Nakahara, MD, PhD; Jerome De Seze; Makoto Kinoshita, MD, PhD; Ruba Deeb Bou-Chahine, PhD; Yasmin Mashhoon, PhD; Becky J. Parks, MD; Kerstin Allen; Ketan Thakar, PhD; Dan Carlin, PhD; Jeannette Stankowski, PhD; Sean J. Pittock, MD
Summary: This study evaluates serum GFAP and NfL levels during treatment with complement component 5 inhibitor therapies in AQP4+ NMOSD, finding decreasing levels over time, suggesting sustained reduction in astrocyte and neuronal damage, which could serve as potential biomarkers of therapeutic efficacy.
1:48 p.m. MT
Topic: Implementing the American Academy of Neurology (AAN) Anti-racism Curriculum into Neurology Residency Education
Presenter: Alissa Ashley Thomas, MD, FAAN (presenter); Lamees H. Alzyoud, MD; Raeann Bourscheid, MD; Gitanjali Das, MD; Parisa Heidari, MD; Rebecca Pollard, MD; Robin Ulep, MD; Jana Wold, MD; Nimish A. Mohile, MD, FAAN
Summary: This presentation assesses the feasibility of incorporating the AAN Anti-Racism Education Program into standard neurology resident education, demonstrating that implementation was viable and led to enhanced confidence among residents and faculty in addressing race and racism.
Thursday, April 18
2:48 p.m. MT
Topic: Factors Associated with Delayed Clinical Evaluation for Patients with Intracerebral Hemorrhage in the ERICH Study
Presenter: Dheeraj Devkrishin Lalwani (presenter); Julia Zabinska; Emma Sylvaine Peasley; Adam De Havenon, MD; Guido Jose Falcone, MD; Joshua Goldstein; Daniel Woo, MD, FAAN; Kevin N. Sheth, MD, FAAN
Summary: This study identifies patient-level factors associated with shorter Onset-to-CT (OCT) times in Intracerebral Hemorrhage (ICH), highlighting the importance of EMS arrival, Hispanic ethnicity, and non-lobar bleeds in facilitating timely diagnosis and treatment.