INJURY AND PREVENTION: DEVELOPING A COMPREHENSIVE, QUANTITATIVE UNDERSTANDING OF HIP MORPHOMETRICS AND BIOMECHANICS IN COLLEGIATE ATHLETES AT RISK FOR DEVELOPING FEMOROACETABULAR IMPINGEMENT SYNDROME
Pac-12 05/03/2018 – 04/30/2021 $844,139
Principle Investigator: Andrew Anderson, PhD
Femoroacetabular impingement syndrome (FAIS) is a common cause of hip pain and dysfunction among collegiate athletes, and a known precursor to hip osteoarthritis. Prevention is the key to reducing rates of FAIS, but research in this area is lacking. The research team believes effective prevention of FAIS starts with an in-depth understanding of how hip anatomy is altered in three-dimensions, and the extent to which abnormal hip anatomy disrupts hip biomechanics, prior to the onset of symptoms. In this study, researchers will compare 3D hip shape and biomechanics between collegiate athletes, control subjects that do not have a history of participation in the same sports, and FAIS patients who are seen in treated in the clinic. The future impact of this work is that it will support a prospective trial to determine if application of a modified training regimen reduces the prevalence of FAIS in athlete.
RANDOMIZED CONTROLLED CLINICAL OUTCOMES OF THE VANGUARD XP BICRUCIATE KNEE SYSTEM (ORTHO.CR.GK9B.13)
BioMet Manufacturing Corp 07/21/2014 – 08/05/2028 $529,098
Principle Investigator: Jeremy Gililland, MD
This study is designed to compare the clinical outcomes in patients who receive the Vanguard XP Knee System and patients who receive the Vanguard CR Femur with CR Bearing.
The Objectives of this study include:
- Compare patient perception of their knee implant feeling “normal / asymptomatic.”
- Compare clinical outcomes through 2 year standard of care follow-up.
- Evaluate patient perceived clinical outcomes and survivorship through 10-years of follow-up.
THE INVESTIGATIONAL PLAN FOR THE EVALUATION OF TEH ACADIA(TM) FACET REPLACEMENT SYSTEM
Globus Medical Inc. 01/01/2013 – 01/15/2020 $213,000
Principle Investigator: Darrel Brodke, MD
Acadia Facet Replacement System was designed to maintain motion and stability of the lumbar spine after full decompression of the neural elements and complete facetectomy. In this IDE multicenter randomized control trial, the Acadia implant is compared to decompression and fusion at a single level in the lumbar spine.
GENOMIC CATEGORIZATION OF CLEAR CELL SARCOMAGENESIS TO GUIDE THERAPEUTIC INVESTIGATION
CURE Childhood Cancer Foundation 07/01/2016 – 01/01/2018 $150,000
Principle Investigator: Kevin Jones, MD, PhD
The goals of this project are to determine the prevalence of secondary mutations in clear cell sarcoma, evaluate the impact of Trp53 or Cdkn2a loss of function on genomic stability in clear cell sarcoma, and identify secondary genetic changes capable of contributing to clear cell sarcoma progression and metastasis.
ENGINEERING V5-TAGGED SS18-SSX IN MICE TO UNDERSTAND THE EPIGENETIC REGULATION OF SS18-SSX IN SYYNOVIAL SARCOMAGENESIS
Paul Nabil Bustany Fund 11/01/2014 – 10/31/2017 $100,000
Principle Investigator: Kevin Jones, MD, PhD
EVALUATION OF SERUM METAL ION LEVELS IN A SERIES OF PATIENTS
Zimmer Inc 06/12/2016 – 06/12/2023 $91,184
Principle Investigator: Jeremy Gililland, MD
PALOVERATENE IN OSTEOCHONDROMAGENSIS
Clementia Pharmaceuticals Inc 01/01/2016 – 03/07/2019 $80,752
Principle Investigator: Kevin Jones, MD, PhD
EVALUATION OF VANGUARD SSK 360 REVISION KNEE SYSTEM GLOBAL DATA COLLECTION (W/PS & PSC BEARINGS ORTHO.CRG1.13)
BioMet Manufacturing Corp 04/29/2013 – 04/29/2026 $64,364
Principle Investigator: Jeremy Gililland, MD
The purpose of this study is to evaluate the performance of the Vanguard® SSK 360 revision knee system. We will evaluate the ability of this system in the the restoration of mechanical alignment, clinical outcomes and survivorship.
FOR ORTHOPAEDIC TRAUMA
Orthopaedic Trauma Association 01/01/2017 – 12/31/2018 $52,650
Principle Investigator: Thomas Higgins, MD
A MULTI-CENTER, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLINDED TRAIL OF EFFICACY AND SAFETY OF RILUZOLE IN ACUTE SPINAL CORD INJURY
AO North America 06/04/2013 – 03/15/2018 $47,552
Principle Investigator: Darrel Brodke, MD
Patients with cervical spine trauma, undergoing surgery to decompress the spinal cord and stabilize the spine, have a moderately high risk of nerve and spinal cord worsening perioperatively. It is hypothesized that Riluzole, a Glutamate/Calcium channel blocker used in ALS, will have an ameliorating effect on this complication. This is an AOSpine sponsored, multicenter prospective placebo-controlled randomized trial.
OMEGA FELLOWSHIP 2019-2020
OMeGA Medical Grant Association $40,000
Principle Investigator: Christopher Peters, MD
The Department of Orthopaedics at the University of Utah acknowledges OMeGA Medical Grants Association and the support of for its generous grant..
RILUZOLE IN PATIENTS W/CERVICAL SPONSDYLOTIC MYELOPATHY UNDERGOING SURGICAL TREATMENT
NOR Consult LLC 10/01/2011 – 10/01/17 $38,725
Principle Investigator: Darrel Brodke, MD
Patients with cervical spondylotic myelopathy, undergoing surgery to decompress the spinal cord, have a moderately high risk of nerve and spinal cord injury perioperatively. It is hypothesized that Riluzole, a Glutamate/Calcium channel blocker used in ALS, will have an ameliorating effect on this complication. This is an AOSpine sponsored, multicenter prospective placebo-controlled randomized trial.
BIOMECHANICAL TESTING OF STABILYNX ROTATOR CUFF REPAIR SYSTEM
Joseph Donahue MD Medical Corp 06/01/2017 – 06/30/18 $26,850
Principle Investigator: Heath Henninger, PhD
The purpose of this study is to compare the biomechanical strength of full thickness rotator cuff repairs using the Stabilynx anchor system to a gold standard rotator cuff repair. Cyclic loading and ultimate failure testing will be performed in paired human cadaver shoulders, where contrasting constructs are placed in matched pairs.
NOVEL MECHANISMS OF FLACOKAWAIN A TARGETING SYNOVIAL SARCOMA
Albert Einstein Medical Center 11/01/2016 – 10/31/17 $25,000
Principle Investigator: Kevin Jones, MD, PhD
GLOBAL CLINICAL EVIDENCE PLAN FOR VANGUARD XP (ORTHO.CR.GK9)
BioMet Manufacturing Corp 06/22/2015 – 06/21/2022 $22,342
Principle Investigator: Jeremy Gililland, MD
This is a Global registry for patients who have undergone knee replacement with a new knee replacement design that saves both the ACL and PCL and is being performed by FORCE-TJR. We are a recruiting site for this study. FORCE-TJR is a national registry and research effort with over 25,000 patients already participating, who are undergoing total joint replacement. This specific research opportunity allows patients to contribute to research, based on patient reported outcomes that we hope will lead to improving the overall quality of life and health for people who require a knee replacement.
DEVELOPMENT OF A METHOD TO DIAGNOSE SUBTLE SYNDESMOSIS
American Orth Foot & Ankle Society 07/01/2017 – 06/30/2018 $20,000
Principle Investigator: Alexej Barg, MD; Charles Saltzman, MD
Our primary goal is to develop a reliable diagnostic method in patients with low-grade, subtle syndesmosis instability using conventional weight-bearing radiographs and/or weight-bearing CT scans. This should help to reduce the rate of unrecognized or misdiagnosed injuries of distal tibiofibular syndesmosis and possible avoid the sequelae of pain, ankle instability and/or the development of posttraumatic ankle osteoarthritis.
AN IMAGING FRAMEWORK FOR CLINICALLY TESTING NEW TREATMENTS TO PREVENT POST-TRAUMATIC OA
University of Iowa 01/01/2017 – 12/31/2018 $20,000
Principle Investigator: Thomas Higgins, MD
The immediate goal of the research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress in ankles following an intra-articular fracture of the tibial pilon. The standing CT scanner holds promise for detecting arthritic changes earlier than other imaging modalities because of the combination of its 3D nature and ability to image joints in a weight-bearing pose. A secondary goal of the research is to enable predictive models for osteoarthritis risk based on measures of post-treatment contact stress, both to inform treatment and so that new interventions can be tested in a manner incorporating risk stratification. A prospective multi-center clinical study of patients having sustained intra-articular fractures of the tibial pilon is being undertaken. Radiographs and standing CT scans obtained at follow-up clinical visits will be collected and used to evaluate joint degeneration. Clinical outcome data will also be collected.
ASSESSING RISK OF OPIOID DEPENDENCE IN TRAUMA PATIENTS: BIOMARKERS AND ATTENTIONAL BIAS OF ABUSE
Orthopaedic Trauma Association 01/01/2017 – 12/31/2017 $20,000
Principle Investigator: Anna Vanderhorst, MD; Thomas Higgins, MD
This study is designed to identify early risk factors for trauma patients who go on to become opioid mis-users. Study participants will undergo psychological testing with the Attentional Bias test, a computer test designed to identify patients who preferentially pay attention to opioid, pain, and pleasure visual cues. Patients will take this test within 24 hours of injury and at the 2 week and 6 week follow-up visits. We will also obtain blood samples within 24 hours of injury, 24 hours post-op, 48 hours post-op, and at the 2 week and 6 week follow up visits. The blood samples will be analyzed for genetic expression of biomarkers linked with opioid abuse.
A LONGITUDINAL PROSPECTIVE ULTRASONOGRAPHIC STUDY OF ULNAR COLLATERAL LIGAMENT: DOES THE LIGAMENT HEAL?
MLB 02/01/2018 – 05/31/2019 $18,677
Principle Investigator: Peter Chalmers, MD
Pitching-related injuries are very common, occurring in 30-74% of pitchers. Tearing of the ulnar collateral ligament (UCL) is one of the most common problems, with 25% of Major League Baseball (MLB) pitchers having undergone surgery for tears of the UCL. It is unknown whether partial tears in the ligament can heal. The purpose this study is to determine the response of the UC in professional pitchers to a single season and a single off-season. We hypothesize that the ligament will respond to activity such that during the season evidence of damage to the ligament will accumulate and during the off-season evidence of damage to the ligament will resolve.
SUPERVISED PHYSIOTHERAPY VERSUS A HOME EXERCISE PROGRAM AFTER REVERSE TOTAL SHOULDER ARTHROPLASTY: A RANDOMIZED TRIAL
Orthopaedic Trauma Association 07/01/2017 – 06/30/2018 $17,773
Principle Investigator: Peter Chalmers, MD
The purpose of this study is to compare a structured home exercise program to supervised physiotherapy post-operatively after primary reverse total shoulder arthroplasty by performing a multi-center, assessor-blinded, randomized clinical trial. This study has two centers: the Departments of Orthopaedic Surgery at Washington University in Saint Louis and at the University of Utah in Salt Lake City.
WHAT HAPPENS ON THE BACK TABLE? VIABILITY OF RIA GRAFT AS A FUNCTION OF TIME AND TEMPERATURE
AO North America 03/15/2017 – 06/30/2018 $9,500
Principle Investigator: William Uffman, MD
The goals of this grant are to:
- Identify the optimal ex-vivo intra-operative storage duration without detrimental effects on graft viability.
- To identify the optimal ex-vivo intraoperative storage temperature for graft viability.
- To provide guidelines for RIA harvest in non-union surgery to best manage modifiable intra-operative factors like storage temperature and time for optimal graft viability.
GREIS UNIVERSITY OF UTAH SPORTS MEDICINE FELLOWSHIP
Depuy Synthes 08/01/2017 – 07/31/2018 $9,200
Principle Investigator: Patrick Greis, MD
The DePuy Fellowship provides support for academic pursuits, research, and salary support of the sports medicine fellows. It helps support and defrays the cost of training. With this additional support, the fellows have been able to attend outside meetings and participate in learning activities that require travel and overnight stays.
INTRAOPERATIVE DATA COLLECTION FOR THE USE OF A NOVEL DIGITAL FLUOROSCOPIC GRID
Orthogrid Systems 01/01/2012 – 12/31/2017 $8,257
Principle Investigator: Jeremy Gililland, MD
The DePuy Fellowship provides support for academic pursuits, research, and salary support of the sports medicine fellows. It helps support and defrays the cost of training. With this additional support, the fellows have been able to attend outside meetings and participate in learning activities that require travel and overnight stays.