DBMI’s research portfolio covers a broad range of domains and applications including clinical decision support (CDS), population health management, natural language processing, bioinformatics, and translational research informatics. Its strategy is to foster multidisciplinary team-science research programs that capitalize on synergy among all three missions of University of Utah Health. Research initiatives include (1) Reimagine EHR, which is leading the nation in the design, development, implementation, and evaluation of interoperable digital health innovations that are integrated with the EHR to improve care; and (2) Translational Bioinformatics and Clinical Research Informatics, which reflects a large focus of DBMI over the last 10 years, provides informatics translation from molecules to bedside and from analytics/systems development, standards, vocabularies and metadata for interoperability. In addition, DBMI pursues research in areas including translational bioinformatics and precision medicine and prepares its students for careers in these growing fields.