Our department is dedicated to conducting research that promotes health equity for all individuals.
We recognize that disparities in healthcare and health outcomes exist, and we are committed to identifying and addressing the root causes of these disparities through rigorous scientific inquiry. Through collaborative partnerships with communities and other organizations, the Department of Population Health Sciences strives to promote health equity and improve the health of all individuals.
Mmadili Ilozumba, PhD, MSPH, CPH
I’m Dr. Mmadili Ilozumba, a Cancer Epidemiologist. My research primarily focuses on understanding the molecular, genetic, environmental, and lifestyle/behavioral risk factors associated with cancer etiology and outcomes. I am particularly passionate about addressing cancer health disparities in racial and ethnic minorities and medically underserved populations.
My research background includes elucidating how changes in gene expression levels and obesity influence the risk of prostate cancer progression (biochemical recurrence) in African American men. Using a novel candidate-driven approach for gene selection, I observed differential gene expression levels in tissue samples, including normal tissues, prostate intraepithelial neoplasia, and tumor tissues. By studying the genes deregulated in patients with obesity compared to those without, I was able to understand how obesity alters gene expression in prostate cancer tumors of African American men. These findings have the potential for considerable clinical impact in individualized prostate cancer risk estimation, treatment modality selection, and risk assessment for prostate cancer progression in African American men.
My research has also examined gene-environment interactions, particularly the role of the mammalian target of rapamycin (mTOR) pathway in breast cancer risk among Black women. By exploring the interplay between obesity, physical activity, energy intake, and mTOR signaling, my work has advanced our understanding of breast cancer etiology and the influence of energy imbalance on the mTOR pathway. This research provides insights for future mechanism-based interventions.
Currently, I am exploring the differences in treatment discontinuation and treatment toxicity among colorectal cancer patients by rural and urban status and age of onset (early-onset vs late-onset colorectal cancer). Additionally, I am investigating multiple risk factors for treatment discontinuation and toxicity, including race, ethnicity, socioeconomic status, and the area deprivation index (ADI), as well as the intersectionality of these factors.
I personally value mentorship because I understand its crucial role in the development of early cancer researchers. I have had the opportunity to mentor several students, providing guidance and support as they navigate their research careers. I strive to be consistently available for my mentees, offering them the knowledge and skills they need to excel in their work. My goal is to help them become the best versions of themselves, fostering their growth and encouraging their success in the field of cancer research.
Who are your partners?
I have collaborated with partners on landmark epidemiologic studies, including the Women’s Health Initiative (WHI), the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium, the Women’s Circle of Health Study (WCHS), the Women’s Health After Breast Cancer (ABC) Study, and the Pathways Study (A Prospective Study of Breast Cancer Survivorship within Kaiser Permanente Northern California). I have also worked with collaborators from labs at major institutes such as Roswell Park Comprehensive Cancer Center, Kaiser Permanente Division of Research, and the University of Florida.
Currently, I am working closely with the Principal Investigators and collaborators of the ColoCare Study, a multicenter, international cohort involving over 4,200 colorectal cancer patients. This study supports interdisciplinary investigations into colorectal cancer outcomes and prognosis, providing a unique resource for my current scientific objectives.
What is something you’re proud of in your work?
I am proud of my contributions to advancing cancer research and making a significant impact on the lives of cancer patients. My work aims to improve survivorship and clinical outcomes while also focusing on cancer prevention. It is incredibly fulfilling to identify the causes of cancer and inform the implementation of preventive measures. For example, addressing behavioral risk factors such as obesity and promoting active lifestyles can significantly reduce cancer risk.
Additionally, I take pride in identifying and addressing social determinants of health, which can have a profound ripple effect on public health policies and patient care. Social determinants of health are the conditions in the environments where people are born, live, learn, and work that influence a wide range of health risks and outcomes including healthcare access and quality, education access and quality, social and community context, economic stability, and neighborhood and built environment. By highlighting gaps in healthcare and advocating for necessary changes, I contribute to creating a healthier society. This comprehensive approach, from prevention to treatment and policy advocacy, allows me to make a meaningful difference in cancer research and patient outcomes.
What is something you’re excited about?
I am deeply excited about cancer research. The entire process, from developing a hypothesis and crafting a research proposal or grant application to collecting data and conducting statistical analyses, is thrilling. The challenge of rigorously testing hypotheses and the anticipation of whether the research findings will support them is a major driving force in my work. It is especially rewarding when my study findings validate my study hypotheses, as it reinforces the significance of the research and its potential impact. Additionally, the prospect of contributing new knowledge to the field of cancer research and ultimately improving patient outcomes fuels my enthusiasm and dedication to this important work.
What brought you to the PHS?
I was drawn to the PHS by the exceptional team led by Dr. Cornelia Ulrich, who is also my Principal Investigator. The opportunity to engage in cutting-edge cancer research and collaborate with leading investigators was highly appealing. Additionally, the chance to experience life in Salt Lake City, Utah, and enjoy its gorgeous mountains was a significant factor in my decision.
What does a perfect weekend look like for you?
A perfect weekend for me starts with completely shutting down my laptop and stepping away from cancer research and all work-related tasks (which hardly happens, lol). I savor quality time with friends, indulge in a self-care routine, and take the time to organize my home. Cooking is another joy, allowing me to unwind and get creative in the kitchen. The highlight of my weekend is attending Holy Mass at the Catholic church, which grounds and rejuvenates me for the week ahead. This blend of relaxation, social connection, and spiritual nourishment makes for an ideal and fulfilling weekend.
