Contributions of inflammatory mediators to age-related neurodegenerative disease and multiple sclerosis.
Regulation of BMP activity; non-canonical and canonical Wnt signaling in hematopoiesis
Developmental processes of cellular morphogenesis and patterning in the primary sensory system.
My laboratory studies the molecular mechanisms that regulate neurogenesis. We use zebrafish as a model organism, focusing on the role of Wnt signaling during development and regeneration.
Genomic imprinting and epigenetic and genetic pathways that influence neuronal circuits that regulate behavior
My lab leverages in vivo optical imaging techniques in order to uncover the synaptic and cellular mechanisms that underlie the brain’s ability to form and recall episodic memories.
Our goal is to identify essential pathways linked to human neurodevelopmental disease. We study these pathways during normal development and in disease states using model systems to identify essential and conserved biological processes.
Characterize the enzymatic properties of a family of GDE enzymes that shed GPI anchors from the plasma membrane.
We study human synapses in health and disease. We seek to understand the molecular mechanisms underlying the development of healthy synapses as well as synaptic abnormalities in human neurons. The ultimate goal of our research is to fuel the discovery of effective treatments for patients with neuropsychiatric disorders associated with autism, intellectual disability, schizophrenia, and epilepsy.
My lab is interested in elucidating the fundamental cellular and molecular processes that underlie memory formation. In particular we are interested in the elucidation of the protein machinery at the synapse that governs long-term storage of information, and how basic cell biological processes have been elaborated in neurons for the purpose of modulating synaptic transmission. In addition, we are interested in how these processes go awry in neurological diseases.
My laboratory is focused on understanding the molecular pathways controlling neural development and degeneration in the retina. The retina is of critical importance since disorders of eye development can lead to congenital blindness, while degeneration of retinal neurons can cause progressive blindness at later ages.
The goal of our research is to understand sensory encoding and brain processing of olfactory information.
Research in the Williams lab focuses on understanding how cell adhesion molecules instruct neurons to build the right type of synapse with the right synaptic partners and what happens to brain function if this process goes awry.
Yost researches an important cellular process in which small molecules (proteoglycans) are added to proteins and allow for these proteins to be in the right place to transmit their signals. These signals are important when cells communicate with each other and are often not working correctly during cancer metastasis (when cancer spreads to other parts of the body).