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THERAPEUTICS FOR INHERITED DISEASES OF THE NERVOUS SYSTEM: Spinocerebellar ataxias, amyotrophic lateral sclerosis (ALS), and Parkinson's disease


Our laboratory studies usually begin with genetic analysis of human families, followed by modeling of the disease process by introducing the mutations found in the families into cells or mice. This group has been interested in amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD), and in the spinocerebellar ataxias, which are inherited, progressive, neurodegenerative diseases that affect the cerebellum (a part of the brain primarily concerned with coordination of movement). 

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Red and blue neurons


A GGC-Repeat Expansion In ZFHX3 Encoding Polyglycine Causes Spinocerebellar Ataxia Type 4 and Impairs Autophagy 

Antisense-Therapie Neurologischer Erkrankungen

Staufen1 Links RNA Stress Granules and Autophagy in a Model of Neurodegeneration

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model

Antisense Oligonucleotide Therapy for Spinocerebellar Ataxia Type 2

The Pulst and Scoles Lab is a talented group of individuals, each playing a key role in driving neurology research forward. We are united by a shared passion for scientific exploration and innovation.

Meet the Team

Pulst and Scoles Lab group photo (black and white)

Latest News

Lab Pictures

Lab Figures/Images

  • New BAC SCA2 model

  • HRS trafficks EGFR-GFP

  • Atxn2 KO blocks C. elegans germ cell development

  • Purkinje cell loss in ATXN2 transgenic mice

  • Anticipation in SCA2