PIONEERING ADULT-ONSET NEURODEGENERATION RESEARCH: Spinocerebellar ataxias, amyotrophic lateral sclerosis (ALS), and Parkinson's disease
GENETIC ANALYSIS OF HUMAN FAMILIES
Our laboratory studies usually begin with genetic analysis of human families, followed by modeling of the disease process by introducing the mutations found in the families into cells or mice. This group has been interested in amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD), and in the spinocerebellar ataxias, which are inherited, progressive, neurodegenerative diseases that affect the cerebellum (a part of the brain primarily concerned with coordination of movement).