Increased Neuroinflammation after Exposure to Repetitive Blast
The purpose of this study is to gain a better understanding of blast-related traumatic brain injury (TBI) in veterans. This study tests the hypothesis that neuroinflammation is elevated in veterans with TBI and a history of blast exposure.
Study Details
Background
Many active-duty military and veterans report exposure to blast-related injuries (up to 74% according to a survey from 2009). Initial reports have shown that long-term exposure to repetitive low-level blasts can lead to TBI and inflammation in the brain. Evidence suggests that prolonged inflammation is harmful to brain structure and function and can lead to Alzheimer's disease, Parkinson's disease, ALS, and other neurological diseases. This study aims to investigate the role of chronic inflammation in response to blast exposures in veteran military populations.
Purpose
This study is part of a series of related projects in conjunction with the University of Virginia, the Navy, and Johns Hopkins, who are all seeking to better understand the relationship between blast-related injury in veterans, inflammation in the brain, and long-term brain health.
Methods
The study will involve a series of surveys and cognitive tests, an MRI, and a blood draw. This information will be used to look at how inflammation in the brain affects behavior, thinking, brain structure, and blood biomarkers.
Participation
Inclusion criteria:
- Ages 18–65 veterans and non-active military members
- Individuals with and without a history of mild traumatic brain injury (concussion) while deployed
- At least three years since their last injury
- Overall adequate medical health
- Able to undergo magnetic resonance imaging (MRI)
Contact info:
If you are interested in participating in the study, please contact us by phone or email:
- Phone: 385-645-4171
- Email: tbicc.uu@gmail.com
Resources
For more information about blast-related TBI and inflammation, please see the following resources:
- A study discussing the impact of blast exposure on long-term health
