Nick Mamalis, MD

Nick Mamalis, MD

Nick Mamalis, MD, is a co-director of Intermountain Ocular Research Center, a nonprofit, independent laboratory that performs basic, in depth scientific research on intra-ocular lenses. In addition, the Center provides services and education to surgeons, clinical ophthalmologists, their patients, and intra-ocular lens manufacturers worldwide. The Moran Eye Center is now pleased to announce the formal merger of the Intermountain Ocular Research Center with the Apple Laboratory, to form the expanded David J. Apple Laboratories for Ophthalmic Devices Research.

Education: MD, University of Utah School of Medicine, Salt Lake City, UT

Academic Appointments: Professor of Ophthalmology & Visual Sciences—University of Utah School of Medicine; Director of Ocular Pathology


 

Liliana Werner, MD, PhD

Liliana Werner, MD, PhD

Liliana Werner, MD, PhD, is a Tenured Professor of Ophthalmology and Visual Sciences and Co-Director of the Intermountain Ocular Research Center at the John A. Moran Eye Center at the University of Utah. She has an MD/Ophthalmology degree from Brazil and a PhD degree (Biomaterials) from France (Université Paris V, René Descartes). She is the 2003 Research to Prevent Blindness Olga Keith Wiess Scholar awardee, member of the Editorial Board of the Journal of Cataract & Refractive Surgery (JCRS), member of the International Intra-Ocular Implant Club, member of the Institutional Review Board (IRB) of the University of Utah, as well as chair of the Continuing Medical Education (CME) Committee of the American Society of Cataract & Refractive Surgery (ASCRS). She is also a former Judge and Chief Judge of the ASCRS Film Festival and former member of the Cataract Subcommittee and the Ophthalmic News & Education Network (O.N.E.) of the American Academy of Ophthalmology (AAO). Dr. Werner’s research is centered on the interaction between ocular tissues and different intraocular lens (IOL) designs, materials, and surface modifications. These include IOLs implanted after cataract surgery, phakic lenses for refractive surgery, and ophthalmic implantable devices in general. She has authored more than 300 peer-reviewed publications and book chapters on the subject, co-edited three books, and received numerous awards in international meetings for scientific presentations, videos, and posters. She has also been a guest speaker in different international meetings in at least 20 countries. Also, Dr. Werner is a consultant for different companies manufacturing IOLs and other ocular biodevices, as well as a consultant for the Food and Drug Administration (FDA).

Education: MD, Federal University of Minas Gerais, Brazil; PhD, Biomaterials from the Université de Paris V (René Descartes), Paris, France

Academic Appointments: Professor of Ophthalmology & Visual Sciences—University of Utah School of Medicine


Postoperative anterior and posterior capsule opacification in an autopsy eye implanted with a plate silicone IOL.
Postoperative anterior and posterior
capsule opacification in an autopsy eye
implanted with a plate silicone IOL.

Patient Care Significance

Each year approximately 1.4 million people in the United States receive intra-ocular lens (IOL) implants after surgical removal of cataracts. Though these replacement lenses improve vision, postoperative complications can occur. The Department of Ophthalmology and Visual Sciences in the University of Utah School of Medicine established a research program in 1984 to study the causes and origins of IOL-related complications. Research performed in this center has resulted in improved quality and design of IOLs, developed new surgical techniques now used by most implant surgeons, and spurred the withdrawal of poorly designed IOLs from the marketplace. We are now studying the causes, prevention, and treatment of posterior capsule opacification and development of IOLs from new soft biomaterials. The Center functions as a national registry for removed IOLs and eye tissue with lens-induced disease. Ophthalmologists worldwide have sent over 16,000 specimens to the center and many eye banks from around the nation regularly send tissues to the center for histopathological analysis.

The Center also conducts research on exciting new technologies. Incorrect IOL power is still a problem following otherwise successful cataract surgery. We have worked with the industry to develop a light adjustable lens which allows lens power to be changed following surgery while the implant is inside the eye.

Another major area of research is the development of an “accommodative” IOL. Currently, IOLs correct distance vision following cataract surgery, but do not allow many patients to have clear near vision for reading. Our clinician-scientists have worked with ophthalmic companies in the development of an accommodative IOL that can provide good distance and near vision.