Microbiology and Immunology Dean Tantin Research Lab
Welcome to the Tantin Laboratory
Our research emphasis is the regulation of gene expression, in the biological settings of the immune response, stem cells and cancer. We use mice and human cells as model systems, along with biochemical, molecular biological and genomic approaches, to probe the full spectrum of transcription factor function from molecular mechanism to physiological function.
Sequence-specific DNA binding transcription factors are the most potent controllers of gene expression, as demonstrated by their central role in development and in lineage reprogramming. Because the patterns of specific gene expression established by transcription factors are critical for successful development and signal response, aberrations in transcription factor function lead to myriad human disorders such as immune dysfunction, developmental defects and cancer. Our lab studies mammalian transcription factors, their cofactors and the chromatin marks they control, to answer fundamental questions regarding lymphocyte development and function, stem cells, pluripotency and malignancy.
Some current major projects in the lab:
Role of the transcription factor Oct1 in stem cells and regeneration of the gut epithelium
Control of Oct1 protein stability by the tumor suppressor BRCA1
Roles of the transcriptional cofactor OCA-B in CD4+ T cell memory and autoimmunity
Roles of OCA-B, GFI1 and IKAROS in leukemia
Oct1/4 interplay in pluripotent cells and developmental gene poising
Oxidative regulation of Oct4 and implications in reprogramming and peri-implantation development