Skip to main content

We have developed statistical quantitative brain mapping technology (3D-SSP/NEUROSTAT) to help investigate brain disorders and to assist clinical diagnosis using PET, SPECT, and MRI.  This software is currently used in more than 50 countries worldwide and used as a common analytical tool for ADNI studies at the University of Michigan imaging core and for the currently funded IAEA research project “Enhancing Capacity of Neuroimaging and Biomarkers: Application in Early-stage Alzheimer's Disease with Comorbidities.”  The software has also been adapted to pre-clinical imaging studies.  This software has contributed to seminal discoveries of functional abnormalities in various brain disorders and is also assisting accurate clinical diagnosis at multiple institutions.

Visit the Neurostat/3D-SSP site.

Related Publications

  1. Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE. A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med. 1995 Jul;36(7):1238-48. PubMed PMID: 7790950
  2. Burdette JH, Minoshima S, Vander Borght T, Tran DD, Kuhl DE. Alzheimer disease: improved visual interpretation of PET images by using three-dimensional stereotaxic surface projections. Radiology. 1996 Mar;198(3):837-43. PubMed PMID: 8628880
  3. Cross DJ, Minoshima S, Nishimura S, Noda A, Tsukada H, Kuhl DE. Three-dimensional stereotactic surface projection analysis of macaque brain PET: development and initial applications. J Nucl Med. 2000 Nov;41(11):1879-87. PubMed PMID: 11079499
  4. Ishii K, Kanda T, Uemura T, Miyamoto N, Yoshikawa T, Shimada K, Ohkawa S, Minoshima S. Computer-assisted diagnostic system for neurodegenerative dementia using brain SPECT and 3D-SSP. Eur J Nucl Med Mol Imaging. 2009 May;36(5):831-40. PubMed PMID: 19148640