This research uses both impact and blast models in rodents to investigate the underlying neuronal substrate brain injury. Also, in collaboration with the Puget Sound VA we have investigated persistent cognitive deficits in Veterans with mild traumatic brain injury from multiple exposures to explosive blasts. The MRI and PET imaging for both projects use similar protocols and images analyses to permit cross-species comparisons.
Related Publications
- Peskind ER, Petrie EC, Cross DJ, Pagulayan K, McCraw K, Hoff D, Hart K, Yu C-E, Raskind MA, Cook DG, Minoshima S. Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms. NeuroImage. 2011; 54:S76-S82. PMID: 20385245. PMCID: PMC3264671
- Petrie, EC., DJ. Cross, V.L. Yarnykh, T. Richards, N.M. Martin, K. Pagulayan, D. Hoff, K. Hart, C. Mayer, M. Tarabochia, M.A. Raskind, S. Minoshima, and E.R. Peskind, Neuroimaging, behavioral, and psychological sequelae of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan war veterans. J Neurotrauma, 2014. 31(5): p. 425-36. PMC3934596 PMID: 24102309
- Cross, DJ, Garwin, GG, Cline, MM, Richards, TL, Yarnykh, V, Mourad, PD, Ho, RJY, Minoshima, S. Paclitaxel improves outcome from traumatic brain injury. Brain Res, 2015. DOI: 10.1016/j.brainres.2015.06.006. PMID: 26086366
- Meabon JS, Huber BR, Cross DJ, Richards TL, Minoshima S, Pagulayan KF, Li G, Meeker KD, Kraemer BC, Petrie EC, Raskind MA, Peskind ER, Cook D. Repetitive blast in veterans and mice causes persistent cerebellar dysfunction. Sci Transl Med. 2016 Jan 13;8(321):321ra6. doi10.1126/scitranslmed.aaa9585. PMID:26764157
- Meabon JS, Cook DG, Yagi M, Terry GE, Cross DJ, Muzi M, Pagulayan KF, Logsdon AF, Schindler AG, Ghai V, Wang K, Fallen S, Zhou Y, Kim TK, Lee I, Banks WA, Carlson ES, Mayer C, Hendrickson RC, Raskind MA, Marshall DA, Perl DP, Keene CD, Peskind ER. Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure. J of the Neurological Sciences, 417: 2020, https://doi.org/10.1016/j.jns.2020.117049.