Overview

Research Training Fellowship

Research opportunities are provided by faculty located at the University of Utah School of Medicine and the VA Medical Center. Faculty in the departments of internal medicine, surgery, pathology, biochemistry, and human genetics are active participants.

Six Broad Areas of Research

Area #1 - Electrophysiology & Cardiac Arrhythmias: This area includes cellular electrophysiology, with Na + and K+ channel molecular biology; computer modeling of arrhythmias; spatial repolarization and activation mapping; late potential localization; mechanisms of clinical VT; ablation techniques; and clinical arrhythmia trials.
CARMA
CVRTI

Area #2 - Congestive Heart Failure: This area includes molecular biology of cardiovascular receptors; receptor biochemistry and physiology; mechanisms of calcium regulation; immunologic mechanisms of myocyte injury; clinical heart failure therapies; clinical immunosuppression in cardiac transplantation; and other clinical transplantation studies.

Area #3 - Clinical Trials and Epidemiology: This area includes trials in arrhythmia therapy; studies of the genetics and treatment of coronary prone pedigrees; novel immunosuppression in human heart transplantation and other studies.

Area #4 - Coronary Artery Disease: This area includes basic studies of the role of the endothelium in atherogenesis; in vivo ultrasound analysis of plaque progression; fibrinolytic trials in myocardial infarction; detection and prevention of accelerated graft coronary atherosclerosis; and the role of chlamydia infection in atherogenesis.

Area #5 - Pathophysiology of Myocyte Excitation: Contraction Coupling: This area includes studies of ATP depletion injury to myocytes; lymphocyte-induced contractile dysfunction; transmembrane calcium movement and calcium homeostasis; regulation of myocyte Na-K ATPase activity; and myocyte function in animal models of heart failure.

Area #6 - Cardiovascular Molecular Biology: This area includes projects examining the molecular genetic basis of the hereditary long QT syndrome; molecular genetics and biology of lipoprotein lipase deficiency; molecular genetics of human hypertension; molecular biology of leukocyte adhesion to endothelium; and elastin pathobiology.
View our T32 opportunities.

Area #7 - Advanced Imaging

There are many other active research projects not listed above. Research outside the above areas is available and capable trainees are encouraged to develop independent research interests. Please visit our research pages for more information.

Collaborations

We also collaborate with the Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), whose primary focus is cardiac electrophysiology and ion transport, with investigative expertise ranging from the molecular level to the whole heart.