Knudsen-HCI People

Projects
- Cell clusters based on hematoxylin features in kidney cancer (link to paper)
- Pipeline for scoring IHC images: PD-L1 expression in lung cancer (link to paper)
- Biomarkers of aggressive prostate cancer (ONECUT2 and cell plasticity) 
- Spatial analysis (link to paper)
- Detection of small organelles in the cytoplasm of  IHC and IF stained cells in culture and in FFPE tissues.
- RNA scope quantification

I received my PhD in Biological Engineering at Utah State University. My dissertation focused on the analysis of biological samples using Raman Spectroscopy. In my current position as a project scientist, I use my technical expertise for analysis of microscopic images. My research interests include the discovery of new biomarkers through multiplexed immunofluorescence imaging of patient tissues, the prediction of protein expression from H&E stained tissue sections and spatially resolved, single cell analysis of protein and RNA expression to characterize cell neighborhoods in the tumor microenvironment.  
I enjoy my work in the field of digital pathology because it allows me to learn cutting-edge, new software and AI based platforms. I develop solutions for challenging problems in image analysis to help improve patient care and the development of new cancer treatments.