Skip to main content
First Semester Enrolled Study Description Publication Title Journal Date
Fall 2009 Biosignature A multi-centered study looking at RNA responses in febrile infants to predict serious bacterial illness Association of RNA Biosignatures with Bacterial Infections in Febrile Infants Aged 60 Days or Younger Journal of American Medical Association 2016
Fall 2009 PICU Glucose



A randomized controlled trial that analyzes whether a blood glucose control protocol better controls blood glucose in pediatric intensive care patients than no protocol The evolution of eProtocols that enable reproducibleclinical research and care methods Journal of Clinical Monitoring and Computing 2012
A Pediatric Intensive Care Unit Bedside Computer Clinical Decision Support Protocol for Hyperglycemia Is Feasible, Safe and Offers Advantages Diabetes Technology & Therapeutics 2017
Design and rationale of Heart and Lung Failure – Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children Contemporary Clinical Trials 2017
  Abdominal Trauma A multi-centered study to identify factors associated with intra-abdominal injury in pediatric blunt-trauma patients Accuracy of the abdominal examination for identifying children with blunt intr-abdominal injuries' Journal of Pediatrics 2014
Relationship of Physician-identified Patient Race and Ethnicity to Use of Computed Tomography in Pediatric Blunt Torso Trauma Academic Emergency Medicine 2016
Comparison of Clinician Suspicion Versus a Clinical Prediction Rule in Identifying Children at Risk for Intra- abdominal Injuries After Blunt Torso Trauma Academic Emergency Medicine 2015
Management of children with solid organ injuries after blunt torso trauma Journal of Trauma and Acute Care Surgery 2015
Use of Oral Contrast for Abdominal Computed Tomography in Children With Blunt Torso Trauma Annals of Emergency Medicine 2015
Association Between the Seat Belt Sign and Intra abdominal Injuries in Children With Blunt Torso Trauma in Motor Vehicle Collisions Academic Emergency Medicine 2014
Use of the focused assessment with sonography for trauma (FAST) examination and its impact on abdominal computed tomography use in hemodynamically stable children with blunt torso trauma Journal of Trauma and Acute Care Surgery 2014
Interobserver Agreement in the Clinical Assessment of Children With Blunt Abdominal Trauma Academic Emergency Medicine 2013
A Multicenter Study of the Risk of Intra-Abdominal Injury in Children After Normal Abdominal Computed Tomography Scan Results in the  Emergency Department Annals of Emergency Medicine 2013
Identifying Children at Very Low Risk of Clinically Important Blunt Abdominal Injuries Annals of Emergency Medicine 2011
Occult Pneumothoraces in Children With Blunt Torso Trauma Academic Emergency Medicine 2014
Sensitivity of Plain Pelvis Radiography in Children With Blunt Torso Trauma Annals of Emergency Medicine 2015
Fall 2009 RESTORE PICU A multi-centered randomized controlled study comparing a sedation protocol versus no protocol to prepare intubated patients for extubation Protocolized sedation vs usual care in pediatric patients mechanicall ventilated for acute respiratory failure: a randomized clinical trial' Journal of American Medical Association 2015
Early High-Frequency Oscillatory Ventilation in Pediatric Acute American Journal of Respiratory and Critical 2016
Dexmedetomidine Use in Critically Ill Children With Acute Respiratory Failure* Pediatric Critical Care Medicine 2016
Patient, Process, and System Predictors of Iatrogenic Withdrawal Syndrome in Critically Ill Children* Critical Care Medicine 2017
Sedation Management in Children Supported on Extracorporeal Membrane Oxygenation for Acute Respiratory Failure Critical Care Medicine 2017
Accuracy of an Extubation Readiness Test in Predicting Successful Extubation in Children  With  Acute Respiratory Failure From Lower Respiratory Tract Disease Critical Care Medicine 2017
Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure Pediatric Critical Care Medicine 2017
Maintaining Interrater Agreement of Core Assessment Instruments in a Multisite Randomized Controlled Clinical Trial: The Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Trial Nursing Research 2017
Fall 2009 Seizure A multi-centered randomized double- blinded controlled study comparing two medications for the treatment of pediatric status epilepticus Lorazepam vs diazapam for pediatric status epilepticus: a randomized clinical trial' Journal of American Medical Association 2014
Fall 2009 THAPCA A multi-centered randomized controlled study analyzing whether hypothermia after pediatric cardiac arrest improves outcome Functional Outcome Trajectories After Out-of-Hospital Pediatric Cardiac Arrest Critical Care Medicine 2016
Summer 2010 Pneumonia A multi-center study of the etiology of pneumonia in hospitalized children Community-acquired pneumonia requiring hospitalization among US children' New England Journal of Medicine 2015
Summer 2010 Cardiology Questionnaire A questionnaire for parents who have recently had a complex congenital heart defect in their child and the impact of counseling Modifiers of stress related to timing of diagnosis in parents of children with complex congenital heart disease Maternal Fetal Neonatal Medicine 2016
Fall 2010 Infant Neuro Trauma A multi-center study to diagnose silent brain injury in infants Validation of the Pittsburgh Infant Brain Injury Score for Abusive Head Trauma' Pediatrics 2016
Fall 2010 Maternal Flu A single-center study to understand how maternal immunization affects infant immunity to influenza Influenza in Infants Born to Women Vaccinated During Pregnancy' Pediatrics 2016
Fall 2010 STAGES A single-centered study of Adipokines, Growth and Endocrine Stages of Adolescent patients Breast-feeding, Leptin:Adiponectin Ratio, and Metabolic Dysfunction in Adolescents with Obesity Southern Medical Journal 2017
Fall 2010 Quality of Life in Children with Disabilities A single-centered survey of perceived quality of life in patients with significant developmental delay and/or medical issues Differing perceptions regarding quality of life and inpatient treatment goals for children with severe disabilities' Academic Pediatrics 2014
Spring 2011 Appendicitis A single-centered study to help improve the diagnosis of appendicitis in children while minimizing exposure to radiation Implementing an ultrasound-based protocol for diagnosing appendicitis while maintaining diagnostic accuracy' Pediatric Radiology 2015
Spring 2011 Fracture Pain A single-centered study to determine the quickest, most effective pain relief for children presenting to the ER with possible extremity fracture Pediatric emergency department triage-based pain guideline utilizing intranasal fentanyl: Effect of implementation American Journal of Emergency Medicine 2018
Spring 2011 Burden of Cancer A single-centered study to evaluate the burden of childhood cancer care on patient’s and their families Financial Burden of Pediatric Cancer for Patients and Their Families' Journal of Oncology Practice 2014
Spring 2011 Asthma Severity A single-centered study to identify genetic variables in response to asthma medication use in children Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma' American Journal of Respiratory Cell & Mole 2015
Fall 2011 Progesterone A multi-centered pilot study that collects data for a larger study of progesterone after a traumatic brain injury Progesterone for neuroprotection in pediatric traumatic brain injury' Pediatric Clinical Care Medicine 2015
Spring 2012 Skull Fracture A single-centered study assessing neurological complications of patients with an isolated skull fracture who have been discharged from the Emergency Department Impact of newly adopted guidelines for management of children with isolated skull fractures' Journal of Pediatric Surgery 2014
Fall 2012 LP Positioning A single-centered study comparing the success of lumbar puncture in two positions with infants A randomized controlled trial of positioning for lumbar puncture in young infants' Pediatric Emergency Care 2016
Spring 2013 CDAT A single-centered study to evaluate how traumatic brain injury affects children’s development Persistent post-concussion symptoms after injury Pediatrics 2018
Healthcare utilization and missed workdays of parents of children with traumatic brain injury Journal of Head Trauma Rehabilitation 2019
Ability of the PILOT score to predict 6-month functional outcomes in pediatric patients with moderate-severe traumatic brain injury Journal of Pediatric Surgery 2019
Longitudinal developmental outcomes after traumatic brain injury in young children: are infants more vulnerable than toddlers? Journal of Neurotrauma 2019
Psychosocial and executive function recovery trajectories one year after pediatric traumatic brain injury: the influence of age and injury severity Journal of Neurotrauma 2018
Spring 2014 PEER A single-centered study to evaluate the effects of the environment on gene expression in the placenta The fascinating and complex role of the placenta in pregnancy and fetal well-being' Journal of Midwifery Womens Health 2015
Spring 2015 Orencia A single-centered study characterize and evaluate the safety of adatacept in Juvenile Idiopathic Arthritis Subcutaneous Abatacept in Patients WithPolyarticular Course Juvenile Idiopathic Arthritis Arthritis & Rheumatology 2018
Spring 2015 SoMo A single-centered study to examine the use of social media among families whose children are treated in Oncology and assess their satisfaction with provided services Social Media Use Among Parents and Caregivers of Children with Cancer Journal of Pediatric Oncology 2018
Summer 2015 ESETT A single centered community consultation survey to gather feedback for an upcoming study on epilepticus that is exempt from informed consent Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus The New England Journal of Medicine 2019
Summer 2016 Survivors of Care (SOAR) A multi-centered study to define RNA Biosignatures in febrile infants with baterial, viral, or viral-bacterial infections An Assessment to Inform Pediatric Cancer Provider Development and Delivery of Survivor Care Plans. Journal of Cancer Education 2015
Survivorship care plan experiences among childhood acute lymphoblastic leukemia patients and their families. BMC Pediatrics 2019
Fall 2016 Asthma IV Magnesium A multi-centered study to better understand how magnesium affects kids with asthma and how their bodies process it Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma European Journal of Clinical Pharmacology 2018
Fall 2016 Poison Control Study A single-centered study to assess parents attitudes and behaviors related to managing pediatric poisonings Study of Caregivers Regarding Pediatric Poisoning Clinical Pediatrics 2019
Spring 2017 Bronchiolitis Study A single-centered study to learn about what happens to children with bronchiolitis after they are sent home following hospitalization Outcomes of Follow-up Visits After Bronchiolitis Hospitalizations JAMA Pediatrics 2018
Spring 2017 Tetanus Study A single-centered survey to assess accuracy of need for tetanus vaccine/booster after laceration based on parental history compared with the state database Accuracy of Parental-Reported Tetanus Vaccination Status for Children With Lacerations Pediatric Emergency Care 2019
Fall 2020 Social Determinants of Health A single centered study to understand and identify the scope of social determinants of health within the PCH ED patient population. Social Needs Screenings During Pediatric Emergency Department Visits: Disparities in Unmet Social Needs Academic Pediatrics 2022