UROLOGY RESEARCH
PUBLICATIONS
Explore high impact publications by year from the University of Utah Division of Urology.
- Tonna JE, Hanson HA, Cohan JN, McCrum ML, Horns JJ, Brooke BS, Das R, Kelly BC, Campbell AJ, Hotaling J.
- BMC Health Serv Res. 2020 Dec 3;20(1):1119.
- Moghalu OI, Das R, Horns J, Campbell A, Hotaling JM, Pastuszak AW.
- Int J Impot Res. 2020 Oct 6.
- Cheng PJ, Keihani S, Roth JD, Pariser JJ, Elliott SP, Bose S, Khavari R, Crescenze I, Stoffel JT, Velaer KN, Elliott CS, Raffee SM, Atiemo HO, Kennelly MJ, Lenherr SM, Myers JB.
- Neurourol Urodyn. 2020 Aug;39(6):1771-1780.
Factors associated with appropriate and low-value PSA testing.
- Oswald N, Lin T, Haaland B, Flynn M, Kawamoto K, Cooney KA, Lowrance W, Hanson HA, O'Neil B.Cancer Epidemiol. 2020 Jun;66:101724.
- Armstrong JM, Martin CR, Dechet C, Morton K, Evans D, Ambrose J, Maughan BL, O'Neil B, Lowrance W.
- Urol Oncol. 2020 Jul;38(7):636.e1-636.e6
Combining Drive Time and Urologist Density to Understand Access to Urologic Care.
- Leiser CL, Anderson RE, Martin C, Hanson HA, O'Neil B.
- Urology. 2020 May;139:78-83
- Keihani S, Rogers DM, Putbrese BE, Anderson RE, Stoddard GJ, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Fick CN, Smith BP, Okafor BU, Askari R, Miller BD, Santucci RA, Carrick MM, Allen L, Norwood S, Hewitt T, Burks FN, Heilbrun ME, Gross JA, Myers JB; in conjunction with the Trauma and Urologic Reconstruction Network of Surgeons.
- J Trauma Acute Care Surg. 2020 Mar;88(3):357-365.
Utilization of Radiographic Imaging for Infant Hydronephrosis over the First 12 Months of Life.
- Schaeffer AJ, Cartwright PC, Lau GA, Ebert MD, Fino NF, Nkoy FL, Hess R.
- Adv Urol. 2020 Jul 30;2020
Drs. Doug Carrell and James Hotaling authors on pivotal work examining the effects, in men, of zinc and folic acid supplementation on live birth rates, published this month in JAMA. The article was entitled “Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment”.
Dr. Hotaling was co-author along with Drs. Brad Cairns and Jingtao Guo in the first ever genomic study of testis cellular differentiation during puberty and the effects of testosterone suppression in transwomen. The article was published in Cell Stem Cell and entitled “The Dynamic Transcriptional Cell Atlas of Testis Development During Human Puberty.”
- Pastuszak AW, Thirumavalavan N, Kohn TP, Lipshultz LI, Eisenberg ML.
- Sex Med. 2019 Dec;7(4):403-408.
- Martin C, West JM, Palermo S, Patel DP, Presson AP, Comploj E, Pycha A, Hancock JB, Dechet CB, Trenti E.
- Urologia. 2019 Nov;86(4):183-188.
- Tiegs AW, Landis J, Garrido N, Scott RT Jr, Hotaling JM.
- Urology. 2019 Oct;132:109-116.
- Hanson HA, Martin C, O'Neil B, Leiser CL, Mayer EN, Smith KR, Lowrance WT.
- J Urol. 2019 Dec;202(6):1209-1216.
- Keihani S, Putbrese BE, Rogers DM, Zhang C, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Fick CN, Smith BP, Okafor BU, Askari R, Miller B, Santucci RA, Carrick MM, Kocik JF, Hewitt T, Burks FN, Heilbrun ME, Myers JB; in conjunction with the Trauma and Urologic Reconstruction Network of Surgeons.
- J Trauma Acute Care Surg. 2019 Jun;86(6):974-982.
- Myers JB, Lenherr SM, Stoffel JT, Elliott SP, Presson AP, Zhang C, Rosenbluth J, Jha A, Patel DP, Welk B; Neurogenic Bladder Research Group.
- J Urol. 2019 Sep;202(3):574-584.
- Keihani S, Rogers DM, Putbrese BE, Moses RA, Zhang C, Presson AP, Hotaling JM, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Smith BP, Okafor BU, Askari R, Miller B, Santucci RA, Carrick MM, Kocik JF, Hewitt T, Burks FN, Heilbrun ME, Myers JB; in conjunction with the Trauma and Urologic Reconstruction Network of Surgeons.
- J Trauma Acute Care Surg. 2019 May;86(5):774-782.
- Keihani S, Putbrese BE, Rogers DM, Patel DP, Stoddard GJ, Hotaling JM, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Fick CN, Smith BP, Okafor BU, Askari R, Miller B, Santucci RA, Carrick MM, Kocik JF, Hewitt T, Burks FN, Heilbrun ME, Myers JB; in conjunction with the Trauma and Urologic Reconstruction Network of Surgeons.
- J Trauma Acute Care Surg. 2019 Feb;86(2):274-281.
- Myers JB, Lenherr SM, Stoffel JT, Elliott SP, Presson AP, Zhang C, Rosenbluth J, Jha A, Patel D, Welk B; Neurogenic Bladder Research Group (NBRG. org).
- Neurourol Urodyn. 2019 Jan;38(1):285-294.
- Martin C, Haaland B, Tward AE, Dechet C, Lowrance W, Stephenson RA, Hanson H, O'Neil B.
- J Urol. 2019 Apr;201(4):751-758.
The adult human testis transcriptional cell atlas.
- Guo J, Grow EJ, Mlcochova H, Maher GJ, Lindskog C, Nie X, Guo Y, Takei Y, Yun J, Cai L, Kim R, Carrell DT, Goriely A, Hotaling JM, Cairns BR.
- Cell Res. 2018 Dec;28(12):1141-1157.
Establishing a stable, repeatable platform for measuring changes in sperm DNA methylation.
- Abbasi M, Smith AD, Swaminathan H, Sangngern P, Douglas A, Horsager A, Carrell DT, Uren PJ.
- Clin Epigenetics. 2018 Sep 18;10(1):119.
- O'Neil B, Martin C, Kapron A, Flynn M, Kawamoto K, Cooney KA.
- Cancer Epidemiol. 2018 Oct;56:112-117.
- Carrell DT, Salas-Huetos A, Hotaling J.
- Fertil Steril. 2018 Aug;110(3):401-402.
- Patel B, Meeks H, Wan Y, Johnstone EB, Glenn M, Smith KR, Hotaling JM.
- Cancer Epidemiol. 2018 Oct;56:1-5.
- Alder NJ, Keihani S, Stoddard GJ, Myers JB, Hotaling JM.
- BJU Int. 2018 Oct;122(4):688-694.
- Keihani S, Xu Y, Presson AP, Hotaling JM, Nirula R, Piotrowski J, Dodgion CM, Black CM, Mukherjee K, Morris BJ, Majercik S, Smith BP, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Thomsen PB, Erickson BA, Baradaran N, Breyer BN, Miller B, Santucci RA, Carrick MM, Hewitt T, Burks FN, Kocik JF, Askari R, Myers JB; Genito-Urinary Trauma Study Group.
- J Trauma Acute Care Surg. 2018 Mar;84(3):418-425.
Familial Cancer Clustering in Urothelial Cancer: A Population-Based Case-Control Study.
- Martin C, Leiser CL, O'Neil B, Gupta S, Lowrance WT, Kohlmann W, Greenberg S, Pathak P, Smith KR, Hanson HA.
- J Natl Cancer Inst. 2018 May 1;110(5):527-533.
- Rao PK, Boulet SL, Mehta A, Hotaling J, Eisenberg ML, Honig SC, Warner L, Kissin DM, Nangia AK, Ross LS.
- J Urol. 2017 Apr;197(4):1121-1126.
- Bassett MR, Santiago-Lastra Y, Stoffel JT, Goldfarb R, Elliott SP, Pate SC, Broghammer JA, Gaither T, Breyer BN, Vanni AJ, Voelzke BB, Erickson BA, McClung CD, Presson AP, Tward JD, Myers JB; Neurogenic Bladder Research Group; Trauma and Urologic Reconstructive Network of Surgeons.
- J Urol. 2017 Mar;197(3 Pt 1):744-750.
- Chandrapal JC, Nielson S, Patel DP, Zhang C, Presson AP, Brant WO, Myers JB, Hotaling JM.
- BJU Int. 2016 Dec;118(6):994-1000.
Risk of childhood mortality in family members of men with poor semen quality.
- Hanson HA, Mayer EN, Anderson RE, Aston KI, Carrell DT, Berger J, Lowrance WT, Smith KR, Hotaling JM.
- Hum Reprod. 2017 Jan;32(1):239-247.
Gender Differences in Publication Productivity Among Academic Urologists in the United States.
- Mayer EN, Lenherr SM, Hanson HA, Jessop TC, Lowrance WT.
- Urology. 2017 May;103:39-46.
Orgasmic Function after Radical Prostatectomy.
- Du K, Zhang C, Presson AP, Tward JD, Brant WO, Dechet CB.
- J Urol. 2017 Aug;198(2):407-413.
- Martin L, Mullaney S, Peche W, Peterson K, Chan S, Morton R, Wan Y, Zhang C, Presson AP, Emery B, Aston K, Jenkins T, Carrell D, Hotaling J.
- Urology. 2017 Sep;107:114-119.
- Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR.
- Cell Stem Cell. 2017 Oct 5;21(4):533-546.
- Son J, Samuel R, Gale BK, Carrell DT, Hotaling JM.
- Biomicrofluidics. 2017 Sep 27;11(5)
GRANTS
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PROJECTS
- Imaging utilization for post-natal hydronephrosis is proportional to hydronephrosis grade, Anthony J. Schaeffer, MD, MPH
- Frequency of imaging in infants with uretero-pelvic junction-like hydronephrosis
Anthony J. Schaeffer, MD, MPH, Neha R. Malhotra, MD, Glen A. Lau, MD, Patrick C. Cartwright, MD, Nora F. Fino, MS, Flory L. Nkoy, MD, MS, MPH, Mark D. Ebert, MD, Rachel Hess, MD, MS - Proximal Fistula Repair Not More Likely to Fail Compared to Distal Fistula Following Hypospadias Repair, Glen Lau, MD, Austen Slade, MD
- Closure of distal versus proximal urethrocutaneous fistulae after hypospadias repair
Austen D. Slade M.D., Neha M. Malhotra M.D., Anthony J. Schaeffer M.D., Patrick C. Cartwright M.D., Glen A. Lau M.D.
Objectives
Urethrocutaneous fistulae are the most common complication following hypospadias repair, and proximal hypospadias carry a nearly two-fold risk for fistula formation compared to distal. The impact of fistula location on success of repair has not been well studied. We hypothesized that repairs of distal fistulas would be more successful when compared to proximal fistulas and aimed to identify surgical factors that may affect these outcomes.
Methods
Retrospective review of all patients undergoing repair of fistula at our institution from 2014 to 2017 following hypospadias repair. Data collected included location of fistula, size of fistula, type of magnification used, suture type, use of post-operative stent, number and type of interposition layers used. Univariate analysis was performed using chi-square tests for categorical variables, multivariate analysis was performed using logistic regression.
Results
During the study period 31 patients presented for fistula repair. There were 17 (54.8%) distal and 14 (45.2%) proximal fistulas. There was no difference in success for distal (70.6% successful) vs proximal (63.4%) fistula repair (p = 0.71). Proximal fistulae were not more likely to be stented (p=0.24) but were more likely to have had an interposition layer (p=0.02). Median age at initial repair was 7 months (IQR 5, mean 11.5 months). Median time from hypospadias repair to diagnosis of fistula was 7 months (IQR 11.5, mean 9.8 months).
Conclusions
Based on our data, proximal and distal fistulae after hypospadias repair have comparable rates of successful closure. Notably, proximal fistula repairs were more likely to utilize an interposition coverage layer than distal fistula repairs. Use of an interposition layer has previously been shown to decrease fistula formation after initial hypospadias repair, and this could also affect outcomes in fistula repair. - No difference in surgical outcomes after MACE with multi-disciplinary clinic follow-up, M. Chad Wallis, MD, Neha R. Malhotra, MD
- The effect of a multidisciplinary colorectal clinic on Malone antegrade continence enema (MACE) outcomes
Neha R. Malhotra, Glen A. Lau, Austen D. Slade, Zachary J. Kastenberg, Sarah Zobell, Michael D. Rollins, M. Chad Wallis
Introduction
The Malone antegrade continence enema (MACE) allows patients to perform colonic irrigation, manage fecal incontinence and empty in a more predictable manner, improve social continence. Various technical modifications have improved outcomes and decreased complications. A critical component to success is regular follow-up and adherence to a bowel program; therefore, it has been suggested that a team approach to bowel management should be employed. We hypothesized that a multi-disciplinary colorectal clinic would improve surgical outcomes in patients with MACE. - Materials and Methods
A multi-disciplinary colorectal clinic (CRC) was implemented at our institution in 2011. This clinic, led by a general surgeon, is a collaborative effort between general surgeons, urologists, gastroenterologists and gynecologists and utilizes physicians, advanced practice providers and nurses as well as social workers and nutritionists. All patients undergoing MACE are eligible to follow in CRC, regardless of operating service. Patients undergoing MACE in the two years prior (2009, 2010) and the two years after (2011, 2012) were identified and a retrospective chart review was performed. Outcomes of patients who were followed in CRC were compared to those who did not follow in CRC (control group). Univariate analysis was performed using chi-square tests for categorical variables. A small sample size precluded multivariate analysis. Mann-Whitney test was used to analyze non-parametric variables. Statistical significance was determined by a p value of < 0.05. Statistical analysis was performed using SPSS Version 25 (IBM, Armonk, NY).
Results
59 patients were identified in the four years prior to and after initiation of CRC; 35 (59.3%) patients were followed in CRC and 24 (40.7%) were not. Patients in CRC were more likely to have phone appointments (CRC median 3, control median 0; p =<0.01), but had comparable numbers of clinic visits (CRC median 4, control median 6; p = 0.17). There was no difference in post-operative ED visits (p = 0.09), unscheduled post-operative clinic visits (p = .90), early complications (p = 0.24), late complications (p = 0.93), or reoperations (p = .60; skin level revision p = 0.97, takedown p = 0.97, re-do MACE p = 0.40) in either cohort. Patients undergoing MACE by general surgery were more likely to be seen in the CRC than urology patients (14.3% of urology MACEs, 76.7% of general surgery MACEs; p < 0.01)
Conclusion
Our study did not show a difference in surgical outcomes with follow-up in a multidisciplinary colorectal clinic; this may have been due to limited sample size. Our results do show a significant increase in phone visits and a non-significant decrease in clinic visits. There was no difference in post-operative ED visits, patient phone calls or unscheduled visits. Further work is necessary to determine if increased phone follow-up with potentially decreased clinic visits improves patient satisfaction and decreases cost of care. - Trend towards decreased PACU time in boys undergoing caudal block prior to hypospadias repair, M. Chad Wallis, MD
- The effect of a multidisciplinary colorectal clinic on Malone antegrade continence enema (MACE) outcomes
Neha R. Malhotra, Glen A. Lau, Austen D. Slade, Zachary J. Kastenberg, Sarah Zobell, Michael D. Rollins, M. Chad Wallis
Purpose
The efficacy of caudal versus penile blocks is not well characterized among boys undergoing hypospadias repair. This study informs a prospective, double-blinded, randomized, controlled trial of caudal vs. penile blocks for hypospadias repair. We hypothesized that caudal blocks would provide superior perioperative analgesia.
Methods
A single-institution retrospective review of prospectively-enrolled boys undergoing initial hypospadias repair was performed. Boys were excluded if they received dual caudal and penile blocks, if electronic anesthesia records were not available, or if additional procedures were performed under the same anesthetic. Patient characteristics, procedure characteristics, postoperative times, pain scores in the first 2 postoperative hours, and opioid administration were recorded. Univariate, non-parametric tests of significance were performed to evaluate between-group differences.
Results
106 boys were repaired at a median 7.3 months. The median urethroplasty length was 8mm and 76% of repairs were stented. 89 boys received penile blocks and 17 received caudal blocks. The groups were similar in terms of age and weight. The group receiving caudal blocks had a significantly longer urethroplasty length (p = 0.02; Table 1). The median anesthesia and PACU times were 134 and 37 minutes, respectively. The median intra- and postoperative weight-based morphine equivalents administered were 4.8mg/kg and 0mg/kg, respectively. Boys undergoing caudal blocks were more likely undergo stent placement and had significantly longer anesthesia (p = 0.02) and surgery (p = 0.01) times. There were no significant between-group differences in PACU time, postoperative pain scores, or opioid use. Perioperative use of non-opioid analgesics was variable (Table 2).
Conclusions
While no significant differences in the efficacy of caudal versus penile blocks were demonstrated, there was a trend towards decreased PACU time in boys undergoing caudal blocks. Standardization of perioperative non-opioid analgesic use is essential in the upcoming prospective trial.
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