Lung Health Research Center

The Lung Health Research Center was established in 1986 under the direction of Dr. Richard E. Kanner, as part of the first major initiative of The Heart, Lung, and Blood Institute in screening for an intervention in early lung disease. Principal Investigators for the Lung Health Research Center are Drs. Richard Kanner and Mary Beth Scholand.

The first lung health study involved a randomized clinical trial involving 10 clinical centers in the United States and Canada that enrolled 5,887 male and female smokers age 35-60 years with early chronic obstructive pulmonary disease (COPD).

COPD Research

1. Lung Health Study I, II, III
2. The Lung Cancer Substudy (LCS). 1994-1999
3. A Multicenter Evaluation of the Effects of Zyban versus Placebo in a population of smokers with COPD. Glaxo-Welcome 1998-2000
4. A Double-Blind Randomized, Placebo and Active Controlled Multicenter, Parallel Group, Dose Ranging Study of L753099 in Patients with COPD. Merk & Co. 2000
5. A Randomized, double-blind, parallel group trial assessing the efficacy and safety in subjects at least 12 years of age with chronic asthma currently treated with inhaled corticosteroids. Glaxo-Welcome, Inc. 2000
6. Efficacy and safety of MF-DPI in the Treatment of Patients with Chronic Obstructive Pulmonary Disease. Schering Plough. 2001-2002
7. A randomized, 24 week, double-blind, placebo controlled, parallel group study to evaluate the efficacy and tolerability of Ariflo (15 mg BID) in patients with Chronic Obstructive Pulmonary Disease. Glaxo-Smithkline. 2001-2002
8. A phase IIIB, multicenter, randomized, double-blind, placebo-controlled, parallel group trial assessing the rate of decline of lung function with Tiotropium 18 mcg inhalation capsule once daily in patients with chronic obstructive pulmonary disease