Selected Publications
- Age-related macular degeneration: natural history revisited in geographic atrophy. Broadbent E, Künzel SH, Pfau M, Schmitz-Valckenberg S, Fleckenstein M. Eye (Lond). 2025 Feb;39(2):217-227.
- Informing Endpoints for Clinical Trials of Geographic Atrophy. Lad EM, Fleckenstein M, Holz FG, Shen L, Priore LVD, Silva R, Staurenghi G, Waheed N, Chakravarthy U. Annu Rev Vis Sci. 2024 Sep;10(1):455-476.
- [Use of artificial intelligence in geographic atrophy in age-related macular degeneration]. Chang P, von der Emde L, Pfau M, Künzel S, Fleckenstein M, Schmitz-Valckenberg S, Holz FG. Ophthalmologie. 2024 Aug;121(8):616-622.
- Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years. Saßmannshausen M, Döngelci S, Vaisband M, von der Emde L, Sloan KR, Hasenauer J, Holz FG, Schmitz-Valckenberg S, Ach T. Invest Ophthalmol Vis Sci. 2024 Apr 1;65(4):45.
- Association of Lesion Location and Functional Parameters with Vision-Related Quality of Life in Geographic Atrophy Secondary to Age-related Macular Degeneration. Künzel SH, Broadbent E, Möller PT, Lindner M, Goerdt L, Czauderna J, Schmitz-Valckenberg S, Holz FG, Pfau M, Fleckenstein M. Ophthalmol Retina. 2024 Feb 3:S2468-6530(24)00057-5.
- Rationale and Design of VOYAGER: Long-term Outcomes of Faricimab and Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema in Clinical Practice. Guymer R, Bailey C, Chaikitmongkol V, Chakravarthy U, Chaudhary V, Finger RP, Gallego-Pinazo R, Chuan AKH, Ishida S, Lövestam-Adrian M, Parravano M, Luna Pinto JD, Schmitz-Valckenberg S, Sheth V, Souied EH, Chi GC, Gilberg F, Glittenberg C, Scheidl S, Bengus M. Ophthalmol Sci. 2023 Dec 3;4(3):100442.
- Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression. Zouache MA, Richards BT, Pappas CM, Anstadt RA, Liu J, Corsetti T, Matthews S, Seager NA, Schmitz-Valckenberg S, Fleckenstein M, Hubbard WC, Thomas J, Hageman JL, Williams BL, Hageman GS. Nat Commun. 2024 Jan 10;15(1):443. doi: 10.1038/s41467-023-44605-0.PMID: 38200010 Free PMC article.
- Age-Related Macular Degeneration: A Review. Fleckenstein M, Schmitz-Valckenberg S, Chakravarthy U. JAMA. 2024 Jan 9;331(2):147-157.
- Inter-Reader Agreement and Longitudinal Progression of Incomplete/Complete Retinal Pigment Epithelium and Outer Retinal Atrophy in AMD. Schmitz-Valckenberg S, Saßmannshausen M, Braun M, Steffen V, Gao SS, Honigberg L, Ferrara D, Pfau M, Holz FG. Ophthalmol Retina. 2023 Jul 28:S2468-6530(23)00354-8.
- Repeatability of Quantitative Autofluorescence Imaging in a Multicenter Study Involving Patients With Recessive Stargardt Disease 1. Dhooge PPA, Möller PT, Meland N, Stingl K, Boon CJF, Lotery AJ, Parodi MB, Herrmann P, Klein W, Fsadni MG, Wheeler-Schilling TH, Holz FG, Hoyng CB, Schmitz-Valckenberg S; Soraprazan Consortium.Transl Vis Sci Technol. 2023 Feb 1;12(2):1.
- From Genes, Proteins, and Clinical Manifestation: Why Do We Need to Better Understand Age-Related Macular Degeneration? Schmitz-Valckenberg S, Zouache MA, Hageman GS, Fleckenstein M. Ophthalmol Sci. 2022 May 31;2(2):100174.
- Progression of Age-Related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5) or Chromosome 10 (ARMS2/HTRA1) or Both. Schmitz-Valckenberg S, Fleckenstein M, Zouache MA, Pfau M, Pappas C, Hageman JL, Agrón E, Malley C, Keenan TDL, Chew EY, Hageman GS. JAMA Ophthalmol. 2022 Mar 1;140(3):252-260.
- Intersession Repeatability of Structural Biomarkers in Early and Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report. Saßmannshausen M, Thiele S, Behning C, Pfau M, Schmid M, Leal S, Luhmann UFO, Finger RP, Holz FG, Schmitz-Valckenberg S; MACUSTAR Consortium. Transl Vis Sci Technol. 2022 Mar 2;11(3):27.
- A randomized, open-label, multicenter study of switching to brolucizumab with or without a loading dose for patients with suboptimal anatomically controlled neovascular age-related macular degeneration-the FALCON study. Holz FG, Schmitz-Valckenberg S, Wolf A, Agostini H, Lorenz K, Pielen A, Feltgen N, Guthoff R, Quiering C, Clemens A, Jaeger K. Graefes Arch Clin Exp Ophthalmol. 2022 Feb 21.
- Efficacy and Safety of Biosimilar FYB201 Compared with Ranibizumab in Neovascular Age-Related Macular Degeneration. Holz FG, Oleksy P, Ricci F, Kaiser PK, Kiefer J, Schmitz-Valckenberg S; COLUMBUS-AMD Study Group. Ophthalmology. 2022 Jan;129(1):54-63.
- OCT Signs of Early Atrophy in Age-Related Macular Degeneration: Interreader Agreement: Classification of Atrophy Meetings Report 6. Wu Z, Pfau M, Blodi BA, Holz FG, Jaffe GJ, Liakopoulos S, Sadda SR, Staurenghi G, Bjelopera E, Brown T, Chang P, Choong J, Corradetti G, Corvi F, Domalpally A, Hurtenbach C, Nittala MG, Olson A, Pak JW, Pappe J, Saßmannshausen M, Skalak C, Thiele S, Guymer RH, Schmitz-Valckenberg S. Ophthalmol Retina. 2022 Jan;6(1):4-14.
- Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis. Rieck S, Kilgus S, Meyer JH, Huang H, Zhao L, Matthey M, Wang X, Schmitz-Valckenberg S, Fleischmann BK, Wenzel D. Arterioscler Thromb Vasc Biol. 2021 Dec;41(12):2974-2989.
- Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration. Barkana Y, Pondorfer SG, Schmitz-Valckenberg S, Russ H, Finger RP. Sci Rep. 2021 Feb 26;11(1):4764.
- Imaging Features Associated with Progression to Geographic Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 5. Jaffe GJ, Chakravarthy U, Freund KB, Guymer RH, Holz FG, Liakopoulos S, Monés JM, Rosenfeld PJ, Sadda SR, Sarraf D, Schmitz-Valckenberg S, Spaide RF, Staurenghi G, Tufail A, Curcio CA. Ophthalmol Retina. 2021 Sep;5(9):855-867.
- Use of Composite End Points in Early and Intermediate Age-Related Macular Degeneration Clinical Trials: State-of-the-Art and Future Directions. Terheyden JH, Schmitz-Valckenberg S, Crabb DP, Dunbar H, Luhmann UFO, Behning C, Schmid M, Silva R, Cunha-Vaz J, Tufail A, Weissgerber G, Leal S, Holz FG, Finger RP; on behalf of the MACUSTAR Consortium. Ophthalmologica. 2021;244(5):387-395.
- Age-Related Macular Degeneration. Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz- Valckenberg S, Klaver CC, Wong WT, Chew EY. Nat Rev Dis Primers. 2021 May 6;7(1):31.
- Estimation of current and post-treatment retinal function in chronic central serous chorioretinopathy using artificial intelligence. Pfau M, van Dijk EHC, van Rijssen TJ, Schmitz-Valckenberg S, Holz FG, Fleckenstein M, Boon CJF. Sci Rep. 2021 Oct 14;11(1):20446.
- Association of Reading Performance in Geographic Atrophy Secondary to Age-Related Macular Degeneration With Visual Function and Structural Biomarkers. Künzel SH, Lindner M, Sassen J, Möller PT, Goerdt L, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M, Pfau M. JAMA Ophthalmol. 2021 Nov 1;139(11):1191-1199
- Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation. Behning C, Fleckenstein M, Pfau M, Adrion C, Goerdt L, Lindner M, Schmitz-Valckenberg S, Holz FG, Schmid M. BMC Med Res Methodol. 2021 Aug 17;21(1):170.
- Probabilistic Forecasting of Anti-VEGF Treatment Frequency in Neovascular Age-Related Macular Degeneration. Pfau M, Sahu S, Rupnow RA, Romond K, Millet D, Holz FG, Schmitz-Valckenberg S, Fleckenstein M, Lim JI, de Sisternes L, Leng T, Rubin DL, Hallak JA. Transl Vis Sci Technol. 2021 Jun 1;10(7):30.
- Conversion from Intermediate Age-Related Macular Degeneration to Geographic Atrophy in a Proxima B Subcohort Using a Multimodal Approach. Schmitz-Valckenberg S, Braun MD, Thiele S, Ferrara D, Honigberg L, Gao SS, Chen H, Steffen V, Holz FG, Saßmannshausen M. Ophthalmologica. 2021;244(6):523-534.
- Determinants of cone- and rod-function in geographic atrophy: AI-based structure-function correlation.
- Pfau M, Emde LV, Dysli C, Möller PT, Thiele S, Lindner M, Schmid M, Rubin DL, Fleckenstein M, Holz FG, Schmitz-Valckenberg S.Am J Ophthalmol. 2020 Apr 11:S0002-9394(20)30170-7.
- Natural History of Geographic Atrophy Secondary to Age-Related Macular Degeneration: Results from the Prospective Proxima A and B Clinical Trials. Holekamp N, Wykoff CC, Schmitz-Valckenberg S, Monés J, Souied EH, Lin H, Rabena MD, Cantrell RA, Henry EC, Tang F, Swaminathan B, Martin J, Ferrara D, Staurenghi G.Ophthalmology. 2020 Jun;127(6):769-783.
- ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD). Liakopoulos S, Spital G, Brinkmann CK, Schick T, Ziemssen F, Voegeler J, Koch M, Kirchhof B, Holz FG, Pauleikhoff D, Schmitz-Valckenberg S.Br J Ophthalmol. 2020 Feb 17:bjophthalmol-2019-315717. doi: 10.1136/bjophthalmol-2019-315717. Online ahead of print.
- Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group. Spaide RF, Jaffe GJ, Sarraf D, Freund KB, Sadda SR, Staurenghi G, Waheed NK, Chakravarthy U, Rosenfeld PJ, Holz FG, Souied EH, Cohen SY, Querques G, Ohno-Matsui K, Boyer D, Gaudric A, Blodi B, Baumal CR, Li X, Coscas GJ, Brucker A, Singerman L, Luthert P, Schmitz-Valckenberg S, Schmidt-Erfurth U, Grossniklaus HE, Wilson DJ, Guymer R, Yannuzzi LA, Chew EY, Csaky K, Monés JM, Pauleikhoff D, Tadayoni R, Fujimoto J.Ophthalmology. 2020 May;127(5):616-636.
- Type 1 Choroidal Neovascularization Is Associated with Reduced Localized Progression of Atrophy in Age-Related Macular Degeneration. Pfau M, Möller PT, Künzel SH, von der Emde L, Lindner M, Thiele S, Dysli C, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M.Ophthalmol Retina. 2020 Mar;4(3):238-248.
- Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4. Guymer RH, Rosenfeld PJ, Curcio CA, Holz FG, Staurenghi G, Freund KB, Schmitz-Valckenberg S, Sparrow J, Spaide RF, Tufail A, Chakravarthy U, Jaffe GJ, Csaky K, Sarraf D, Monés JM, Tadayoni R, Grunwald J, Bottoni F, Liakopoulos S, Pauleikhoff D, Pagliarini S, Chew EY, Viola F, Fleckenstein M, Blodi BA, Lim TH, Chong V, Lutty J, Bird AC, Sadda SR.Ophthalmology. 2020 Mar;127(3):394-409.