New metabolic function identified for the tumor suppressor BRCA1
Jan 19, 2018 12:00 AM
Investigators from the Department of Pathology, in collaboration with a group at Ohio State University, have shown that BRCA1—a well-known gene which when inherited in mutant form can pre-dispose individuals to breast and ovarian cancer—promotes a form of metabolism associated with more differentiated and noncancerous cells. The new work focuses on a function of BRCA1 in which it tags other proteins for degradation. One such degradation target, a protein known as Oct1, promotes a metabolic profile associated with tumor cells. By catalyzing Oct1 degradation, BRCA1 therefore opposes pro-malignant metabolism, consistent with its tumor suppressive function. “The field is almost entirely focused on the DNA repair aspects of BRCA1,” says Dr. Dean Tantin, senior author on the study. “These findings, and work from others, indicates that the book is not yet closed on the many other functions of BRCA1.” Dr. Rachel Factor, Associate Professor of Pathology, was also involved with the work.
You can read the full article here.