Dr. Bailey DP5 Award
Sep 14, 2020 12:00 AMSummary of research: Dr. Bailey's research seeks to understand how the coagulation system goes awry in viral hemorrhagic fever, with a focus on yellow fever. In collaboration with physician-scientists in Brazil, Dr. Bailey showed that coagulation abnormalities in yellow fever is characterized by the activation and consumption of clotting factors. Using several animal models of yellow fever virus (YFV) infection including non-human primates and mice transplanted with human hepatocytes, Dr. Bailey demonstrated that infection of hepatocytes -- a major target of YFV infection -- does not account for the observed activation of clotting factors. Together, these observations expand current understanding of yellow fever pathogenesis, suggesting that extra-hepatic processes are likely to play a significant role in the development of hemorrhagic yellow fever disease. Dr. Bailey's current research seeks to more fully understand the tissue tropism of YFV, how tropism relates to the development of consumptive coagulopathy, and the molecular interactions that govern these processes. Dr. Bailey's research program also includes projects on Ebola and COVID-19 pathogenesis.