We seek to unravel how key regulatory systems control blood pressure and kidney function, with a particular focus on:

• Renin–Angiotensin and Endothelin Systems 
  We harness genetically modified mouse models—both overexpressing and lacking specific components—to investigate how these systems coordinate cardiovascular and renal physiology.
• Sphingolipids in Kidney Health 
  Utilizing genetic and pharmacological techniques, we are systemically delineating the role ceramides play in kidney disease and health.
• A Diverse Toolkit for Discovery
  Employing a blend of molecular biology, in vivo physiological assessments, and cell culture techniques, we probe the functional contributions of each pathway under both normal and disease states.

Why It Matters

Understanding these regulatory networks provides profound insights into the mechanisms underlying hypertension and renal dysfunction. Our research aims to translate basic science into meaningful advances in treatment strategies for blood pressure control and kidney disease.