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Research Papers


Suryavanshi P, Reinhart KM, Shuttleworth CW, Brennan KC. Action Potentials Are Critical for the Propagation of Focally Elicited Spreading Depolarizations. J Neurosci. 2022 Mar 16;42(11):2371-2383.


Parker PD, Suryavanshi P, Melone M, Sawant-Pokam PA, Reinhart KM, Kaufmann D, Theriot JJ, Pugliese A, Conti F, Shuttleworth CW, Pietrobon D, Brennan KC. Non-canonical glutamate signaling in a genetic model of migraine with aura. Neuron. 2021 Feb 17;109(4):611-628.e8.

Cortez MM, Millsap L, Rea NA, Sciarretta C, Brennan KC. Photophobia and allodynia in persistent post-traumatic headache are associated with higher disease burden. Cephalalgia. 2021 Sep;41(10):1089-1099.

Cortez MM, Millsap L, Brennan KC. Synergistic but separable sensory changes in postural tachycardia syndrome and chronic migraine. Clin Auton Res. 2021 Apr;31(2):263-271.


Sawant-Pokam PA, Vail TJ, Metcalf CS, Maguire JL, McKean TO, McKean NO, Brennan KC. Preventing neuronal edema increases network excitability after traumatic brain injury. J Clin Invest. 2020 Nov 2;130(11):6005-6020.


Cortez MM, Theriot JJ, Rea NA, Gowen FE, Brennan KC. Low-frequency facial hemodynamic oscillations distinguish migraineurs from non-headache controls. Cephalalgia Rep. 2019 Jan 1;2:10.1177/2515816319888216.

Cortez MM, Rae N, Millsap L, McKean N, Brennan KC. Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache. Front Neurol. 2019 May 8;10:478.


Kaufmann D, Brennan KC. The Effects of Chronic Stress on Migraine Relevant Phenotypes in Male Mice. Front Cell Neurosci. 2018 Sep 19;12:294.


Sawant-Pokam PM, Suryavanshi P, Mendez JM, Dudek FE, Brennan KC. Mechanisms of Neuronal Silencing After Cortical Spreading Depression. Cereb Cortex. 2017 Feb 1;27(2):1311-1325.

Kaufmann D, West PJ, Smith MD, Yagen B, Bialer M, Devor M, White HS, Brennan KC. sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. Pharmacol Res. 2017 Mar;117:129-139.

Kaufmann D, Theriot JJ, Zyuzin J, Service CA, Chang JC, Tang YT, Bogdanov VB, Multon S, Schoenen J, Ju YS, Brennan KC. Heterogeneous incidence and propagation of spreading depolarizations. J Cereb Blood Flow Metab. 2017 May;37(5):1748-1762.

Cortez MM, Rea NA, Hunter LA, Digre KB, Brennan KC. Altered pupillary light response scales with disease severity in migrainous photophobia. Cephalalgia. 2017 Jul;37(8):801-811.


Bogdanov VB, Middleton NA, Theriot JJ, Parker PD, Abdullah OM, Ju YS, Hartings JA, Brennan KC. Susceptibility of Primary Sensory Cortex to Spreading Depolarizations. J Neurosci. 2016 Apr 27;36(17):4733-43.

sec-Butylpropylacetamide (SPD) has antimigraine properties. Kaufmann D, Bates EA, Yagen B, Bialer M, Saunders GH, Wilcox K, White HS, Brennan KC.Cephalalgia. 2016 Sep;36(10):924-35.


López-Valdés HE, Clarkson AN, Ao Y, Charles AC, Carmichael ST, Sofroniew MV, Brennan KC. Memantine enhances recovery from stroke. Stroke. 2014 Jul;45(7):2093-2100

Brennan K.C., Mendez JM, Theriot JJ, Sawant PM, Lopez-Valdes HE, Ju YS, Tang, YT. (2014) Minimum Conditions for the Induction of Cortical Spreading Depression in Brain Slices. J Neurophysiol. 2014 Aug 13.


Brennan, K.C., Bates, E.A., Shapiro, R.E., Zyuzin, J., Hallows, W.C., Huang, Y., Lee, H.Y., Jones, C.R., Fu, Y.H., Charles, A.C., and Ptacek, L.J. (2013) Casein kinase 1 delta mutations in familial migraine and advanced sleep phase. Sci Transl Med, 2013 May 1;5(183):183ra56. doi: 10.1126/scitranslmed.3005784.Cover, editorial..

Clarkson, A.N., Lopez-Valdes, H.E., Overman, J.J., Charles, A.C., Brennan, K.C.*, and Carmichael, S.T.* (2013) Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model. J Cereb Blood Flow Metab, doi:10.1038/jcbfm.2013.7. *Equal contribution.

Cortical Sensory Plasticity in a Model of Migraine with Aura. J. Neurosci., 32:15252-15261. Theriot JJ, Toga AW, Prakash N, Ju YS, Brennan KC.

Bogdanov, V.B., Bogdanova, O.V., Koulchitsky, S.V., Chauvel, V., Multon, S., Makarchuk, M.Y., Brennan, K.C., Renshaw, P.F., and Schoenen, J. (2013) Behavior in the open field predicts the number of KCl-induced cortical spreading depressions in rats. Behav Brain Res, Jan 1;236(1):90-3. doi: 10.1016/j.bbr.2012.08.004. Epub 2012 Aug 14. PMID: 22981717.

Brennan KC, Chang JC, He D, Huang H, Miura RM, Wilson PL, Wylie JJ. (2013) A Mathematical Model of the metabolic and perfusion effects on cortical spreading depression. PLoS One 2103 14;8(8).


Tang, Y.T., Kim, J., López-Valdés, H.E., Brennan, K.C., and Ju, Y.S. (2011) Development and characterization of a microfluidic chamber incorporating fluid ports with active suction for localized chemical stimulation of brain slices. Lab Chip, Jul 7;11(13):2247-2254. Epub 2011 May 12. PMID: 21562669.

Chang, J.C., Brennan, K.C., and Chou T. (2011) Tracking monotonically advancing boundaries in image sequences using graph cuts and recursive kernel shape priors. IEEE Trans Med Imaging, May;31(5):1008-1020. Epub 2011 Dec 5. PMID: 22156978.


Chang, J.C., Shook, L.L., Biag, J., Nguyen, E.N., Toga, A.W., Charles, A.C., and Brennan, K.C. (2010) Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression. Brain, 133(Pt 4):996-1012.

Lopez-Valdes, H.E., Beltran-Parrazal, L., Brennan, K.C., and Charles, A.C. (2010) Bradykinin increases resensitization of purinergic receptor signaling in glioma cells. Cancer Cell Int, 10:35.

Tang, Y.T., Kim, J., Lopez-Valdes, H., Brennan, K.C., and Ju, Y.S. (2010) Microfluidic Chamber with Active Suction Ports for Localized Chemical Stimulation of Brain Slices. Proceedings of IEEE 23rd International Conference on Micro Electro Mechanical Systems. Hong Kong, China, 304-307.


Bates, E., Nikai, T., Brennan, K.C., Fu, Y.H., Charles, A., Basbaum, A., Ptacek, L., and Ahn, A. (2009) Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia (Epub ahead of print).


Charles, A., and Brennan, K.C. (2008) A touch of increased pain: cutaneous allodynia in migraine. Ann Neurol, 63(2):130-132.

Charles, A.C., and Brennan, K.C. (2008) Glial cell calcium signaling. In: Squire L (Ed.), Encyclopedia of Neuroscience. Elsevier Press.


Charles, A., Flippen, C., Romero Reyes, M., and Brennan, K.C. (2007) Memantine for prevention of migraine: a retrospective study of 60 cases. J Headache Pain, 8(4):248-250.

Brennan, K.C., Romero Reyes, M., Lopez Valdes, H.E., Arnold, A.P., and Charles, A.C. (2007) Reduced threshold for cortical spreading depression in female mice. Ann Neurol, 61(6):603-606.

Brennan KC, Charles A. (2007) Sumatriptan-naproxen combination for acute migraine. Nat Clin Pract Neurol 2007 Nov 11;3(11):604-5.

Brennan, K.C., Beltran-Parrazal, L., Lopez-Valdes, H.E., Theriot, J., Toga, A.W., and Charles, A.C. (2007) Distinct vascular conduction with cortical spreading depression. J Neurophysiol, 97(6):4143-4151.


Beltran-Parrazal, L., López-Valdés, H.E., Brennan, K.C., Díaz-Muñoz, M., de Vellis, J., and Charles, A.C. (2006) Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium. Am J Physiol Cell Physiol, 291(6):C1193-1197.


Brennan, K.C., Jurewicz, E.C., Ford, B., Pullman, S.L., and Louis, E.D. (2002) Is essential tremor predominantly a kinetic or a postural tremor? A clinical and electrophysiological study. Mov Disord, 17(2):313-316.


Sakai, N., Brennan, K., Weiss, L., and Matile, S. (1997) Toward Biomimetic Ion Channels Formed by Rigid-Rod Molecules: Length-Dependent Ion-Transport Activity of Oligo(p-Phenylene)s. J Am Chem Soc, 119: 8726-8727.

Review Papers


Pietrobon D, Brennan KC. Genetic mouse models of migraine. J Headache Pain. 2019 Jul 12;20(1): 79.


Brennan KC, Pietrobon D. A Systems Neuroscience Approach to Migraine. Neuron. 2018 Mar 7;97(5):1004-1021.


Digre, K.B., and Brennan, K.C. (2012) Shedding light on photophobia. J Neuroophthalmol, Mar;32(1):68-81. doi: 10.1097/WNO.0b013e3182474548. Review. PMID: 22330853.

Ahn, A.H., and Brennan, K.C. (2012) Unanswered questions in headache: how does a migraine attack stop? Headache, Jan;52(1):186-187. doi: 10.1111/j.1526-4610.2011.02078.x. Epub 2012 Jan 3. PMID: 22221296.



Brennan, K.C., and Charles, A. (2010) An update on the blood vessel in migraine. Curr Opin Neurol, 23(3):266-274.

Charles, A., and Brennan, K.C. (2010) The neurobiology of migraine. Handb Clin Neurol, 97:99-108.


Brennan, K.C., and Charles, A. (2009) Sleep and headache. Semin Neurol, 29(4):406-418.

Brennan, K.C., and Toga, A.W. (2009) Intraoperative optical imaging. In: Frostig R (Ed.), Methods for in vivo Optical Imaging of the Central Nervous System. CRC Press.

Charles, A., and Brennan, K. (2009) Cortical spreading depression-new insights and persistent questions. Cephalalgia, 29(10):1115-1124.


Brennan, K.C., and Charles, A.C. (2008) Mechanisms of cortical spreading depression as targets for migraine therapy. In: OlesenJ, Ramadan N (Eds.), Frontiers in Headache Research: Innovative Drug Development for Headache Disorders. Oxford University Press.


Matsumoto, J., Saver, J.L., Brennan, K.C., and Ringman, J.M. (2005) Mitochondrial encephalomyopathy with lactic acidosis and stroke (MELAS). Reviews in Neurological Diseases, 2(1):30-34.