Celiac/Dermatitis Herpetiformis IgG Panel
Ordering Recommendation
•This is the secondary antibody panel for diagnostic assessment and disease monitoring in celiac disease both with and without associated dermatitis herpetiformis. Patients with dermatitis herpetiformis and/or celiac disease may have IgG endomysial and IgG tissue transglutaminase antibodies in sera both in the presence and absence of IgA antibodies; notably, such IgG antibodies may be present in patients with IgA deficiency, although they also may be present in patients who are not IgA deficient.
•To assess for dermatitis herpetiformis or celiac disease, order the Celiac IgA Panel or Dermatitis Herpetiformis IgA Panel concurrently or initially and this panel subsequently.
Components
- IgG endomysial (EMA) antibodies by indirect immunofluorescence
- IgG tissue transglutaminase (transglutaminase type 2, TG2) antibody level by ELISA
Methodology
Indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA)
Performed
Varies
Reported
4-9 days
New York Department of Health (NYDOH) Approval Status
This test is New York DOH approved.
Information Required to Submit with Order
Completed Immunodermatology Laboratory requisition form and copies of both sides of insurance cards or completed billing information
CPT Code(s)
88346; 83516 (86256 x 1 possible)
SPECIMEN REQUIREMENTS
Collect Blood
Plain red top tube or serum separator tube.
Specimen Preparation
2 mL serum separated from blood into serum vial provided in kit (Minimum needed: 0.5 mL)
Storage/Transport Temperature
Room temperature
Conditions with Disclaimer for Potentially Anomalous Results
Hemolyzed or lipemic serum specimens, whole blood
Stability
Ambient: 7 days
Refrigerated: 14 days
Frozen: Indefinitely