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Ordering Recommendation

• This is an autoantibody panel for initial diagnostic assessment and disease monitoring in dermatitis herpetiformis.

• Order concurrently with perilesional skin biopsy for direct immunofluorescence for initial diagnosis.

• Use for disease monitoring with semiquantitative antibody level assessments and tracking

• To screen for other immunobullous diseases in addition to dermatitis herpetiformis, order concurrently with the Pemphigoid Panel, Pemphigus Panel, IgA cell surface antibodies indirect immunofluorescence individual test, IgG collagen type VII antibody ELISA individual test

Components

  • IgA endomysial (EMA) antibodies by indirect immunofluorescence
  • IgA tissue transglutaminase (transglutaminase type 2, TG2) antibody level by ELISA
  • IgA epidermal transglutaminase (transglutaminase type 3, TG3) antibody level by ELISA

Methodology

Indirect immunofluorescence/enzyme-linked immunosorbent assay (ELISA)

Performed

Varies

Reported

4-9 days

New York Department of Health (NYDOH) Approval Status

This test is New York DOH approved except IgA epidermal transglutaminase ELISA.

Information Required to Submit with Order

Completed Immunodermatology Laboratory requisition form and copies of both sides of insurance cards or completed billing information

CPT Code(s)

88346; 83516 x 2 (86256 x 1 possible)
 

SPECIMEN REQUIREMENTS

Collect Blood

Plain red top tube or serum separator tube.  

Specimen Preparation

2 mL serum separated from blood into serum vial provided in kit (Minimum needed: 0.5 mL)

Storage/Transport Temperature

Room temperature  

Conditions with Disclaimer for Potentially Anomalous Results

Hemolyzed or lipemic serum specimens, whole blood  

Stability

Ambient: 7 days
Refrigerated: 14 days
Frozen: Indefinitely