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Ordering Recommendation

• This is a test for autoantibodies in patient’s serum for diagnostic assessment and disease monitoring in celiac disease and dermatitis herpetiformis.

• For initial diagnosis of dermatitis herpetiformis, order concurrently with perilesional skin biopsy for direct immunofluorescence.

• Use for disease monitoring with semiquantitative antibody level assessments and tracking.

• Consider more broad-based panel autoantibody assessment initially and for persisting unexplained or worsening disease activity; panels that include IgA endomysial antibodies: Dermatitis Herpetiformis IgA Panel and Celiac Disease IgA Panel.


Methodology

 

Indirect immunofluorescence - monkey esophagus substrate (additionally, human umbilical cord substrate, as indicated)


Performed

Daily


Reported

2-5 days


New York State Department of Health (NYSDOH) Approval Status

This test is New York State DOH approved.


Information Required to Submit with Order

Completed Immunodermatology Laboratory requisition form and copies of both sides of insurance cards or completed billing information.


CPT Code(s)

88346 (86256 x 1 possible)


SPECIMEN REQUIREMENTS

Collect Blood

Plain red top tube or serum separator tube.  


Specimen Preparation

2 mL serum separated from blood into serum vial provided in kit (Minimum needed: 0.5 mL) 


Storage/Transport Temperature

Room temperature  


Conditions with Disclaimer for Potentially Anomalous Results

Hemolyzed or lipemic serum specimens, whole blood  


Stability

Ambient: 7 days
Refrigerated: 14 days
Frozen: Indefinitely