Publications

Link to full publications

• López DA1, Apostol AC1, Lebish EJ, Valencia CH, Romero-Mulero MC,, Pavlovich P, Hernandez GE, Forsberg EC, Cabezas-Wallscheid N, Beaudin AE. Prenatal inflammation perturbs fetal hematopoiesis and causes persistent changes to postnatal immunity. Cell Reports. Accepted in principle. 1These authors contributed equally.  https://www.biorxiv.org/content/10.1101/2022.05.08.491095v1.full.pdf
• López DA, Beaudin AE.  Isolation and characterization of fetal liver hematopoietic stems cells. Invited Chapter for "Hematopoietic Stem Cell Protocols", Springer Nature Methods in Molecular Biology Series.  In press.  
• Worthington AK, Cool T, Poscablo DM, Hussaini A, Beaudin AE, Forsberg EC. IL7Rɑ, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells.  Development. (2022). 149(8):dev200139.   https://journals.biologists.com/dev/article/149/8/dev200139/274067 
• Hernandez GE, Ma F, Martinez G, Firozabadi N, Salvador J, Juang LJ, Leung J, Zhao P, Lopez DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe ML. Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state. (2021). Nature Cardiovascular Research.  Jan;1(1):67-84. doi: 10.1038/s44161-021-00006-4.  https://www.nature.com/articles/s44161-021-00006-4
• Otsuka KS, Neilson C, Firpo MA, Park AH, Beaudin AE.  Early life inflammation and the developing hematopoietic and immune systems: the cochlea as a sensitive indicator of disruption.  (2021) Cells.10, 3596. https://www.mdpi.com/2073-4409/10/12/3596
• Beaudin, AE. Takes one to B1a: Dismantling the origin of mantle cell lymphoma.  (2021). Journal of Experimental Medicine. 218 (10) e20211482. https://doi.org/10.1084%2Fjem.20211482 
• Lopez DA, Beaudin AE. Layered immunity of the developing thymus. (2021) Blood. 137(8):1003-1004.  https://ashpublications.org/blood/article/137/8/1003/475254
• Apostol AC, Lopez DA, Beaudin AE. A "Switch" in time through genes aligned: Unraveling the genomic landscape of HSC development. (2020) Cell Stem Cell.  5;27(5):695-697. https://www.sciencedirect.com/science/article/pii/S1934590920305051
• Apostol AC, Jensen KDC, Beaudin AE1. Training the fetal immune system through maternal inflammation:  A layered hygiene hypothesis. (2020) Frontiers in Immunology. 11;11:123. 1Corresponding author. https://www.frontiersin.org/articles/10.3389/fimmu.2020.00123/full
• Leung G1, Cool T1, Valencia C, Worthington A, Beaudin AE2, Forsberg EC2.  The lymphoid-associated interleukin-7 receptor (IL-7R) regulates tissue resident macrophage development. (2019).  Development. 146 (14) pii.  1 These authors contributed equally to this work.  2 These authors contributed equally to this work and are co-corresponding authors. https://journals.biologists.com/dev/article-abstract/146/14/dev176180/48958

    Highlighted in "Research Highlight": "On the Origin of Tissue Resident     Macrophages." Development. 146 (14)

• Boyer SW1, Rajendiran S1 Beaudin AE1, Perez-Cunningham J, Smith-Berdan S, Martin EW, Muthuswamy PK, Cheung C, Tsang H, Landon M, Forsberg EC.  (2019) Clonal and quantitative in vivo assessment of hematopoietic stem and progenitor cell differentiation.  Stem Cell Reports 12(4):801-815.1 These authors contributed equally to this work. https://www.sciencedirect.com/science/article/pii/S2213671119300554
• Valentine KM, Davini D, Lawrence TJ, Mullins GN, Mansala M, Al-Kuhlani M, Pinney JM, Davis JK, Beaudin AE, Sindi SS, Gravano DM, Hoyer KK.  (2018) CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease. J Immunol.  1:201 (1):31-40.  https://www.jimmunol.org/content/201/1/31.short
• Apostol AC, Beaudin AE. (2018) Reversing time: EZH1 deficiency hastens definitive hematopoiesis.  Cell Stem Cell.  ;22(3):285-287 https://www.sciencedirect.com/science/article/pii/S1934590918300687
• Cole CK, Byrne A, Beaudin AE, Forsberg EC, Vollmers C. (2018) Tn5Prime, a Tn5 based 5’ Capture Method for Single Cell RNA-seq.  Nucleic Acids Research.   46 (10), e62-e62. https://academic.oup.com/nar/article-abstract/46/10/e62/4934127
• Byrne A, Beaudin AE, Olsen HE, Jain M, Cole C, Palmer T, DuBois RM, Forsberg EC, Akeson M, Vollmers C.  (2017) Nanopore Long-Read RNAseq Reveals Widespread Transcriptional Variation Among the Surface Receptors of Individual B cells.  Nature Communications 19(8): 16027 https://www.nature.com/articles/ncomms16027
• Beaudin AE, Forsberg EC.  (2016) To B1a or not to B1a: do hematopoietic stem cells contribute to tissue-resident immune cells?   Blood. 128(24):2765-2769. https://ashpublications.org/blood/article-abstract/128/24/2765/35980
• Beaudin AE, Boyer SW, Perez-Cunningham J, Hernandez GE, Derderian SC, Jujuvarapu C, Aaserude E, MacKenzie T, Forsberg EC.  (2016) A transient development hematopoietic stem cell gives rise to innate-like B- and T-cells.  Cell Stem Cell.  1;19(6):768-783. https://www.sciencedirect.com/science/article/pii/S1934590916302600

    
Comment in:  Vanhee S, Yuan J. (2016). Fetal to adult hematopoiesis with the “Flk” of a Switch.  Cell Stem Cell 1;19(6):673-674.

Comment in:  Waas B, Maillard I.  (2017) Fetal hematopoietic stem cell make waves.  Stem Cell Investigation.7;4:25

• Hoeffel G, Chen J, Lavin Y, Low D, Almeida A, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poidinger M, Zolezzi F, Larbi A, Ng LG, Chan JKY, Greter M, Becher B, Samokhvalov IM, Merad M, Ginhoux F.  (2015) C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity, 42(4):665-78. https://www.sciencedirect.com/science/article/pii/S1074761315001259

    
Comment in:  Schneider C, Kopf M. (2015) tEMPting fate MaYBe the solution. Immunity, 42(4):597-9.

• Beaudin AE, Boyer SW, Forsberg EC.  (2014) Flk2/Flt3 promotes both myeloid and lymphoid development by expanding non-self-renewing multipotent hematopoietic progenitor cells. Experimental Hematology, 42(3):218-229. https://www.sciencedirect.com/science/article/pii/S0301472X13009223

    Highlighted in: “In This Issue”, Experimental Hematology, March 2014

• Epelman S, Lavine KJ, Beaudin AE, Sojka D, Brija T, Schwendener R, Forsberg EC, Yokoyama W, Murphy KM, Colonna M, Randolph GJ, Mann DL.  (2014) Novel cardiac macrophage populations during steady-state and inflammation. Immunity, 40(1):91-104. https://www.sciencedirect.com/science/article/pii/S107476131300558X

Comment in: Cohen HB, Mosser DM. (2014) Cardiac macrophages: how to mend a broken heart. Immunity, 40(1):3-5.  

• Abarinov EV1 Beaudin AE1, Field MS, Perry CA, Allen RH, Stabler SP, Stover PJ.  (2013) Disruption of Shmt1 impairs hippocampal neurogenesis and mnemonic function in mice. Journal of Nutrition, 143(7): 1028-35. 1These authors contributed equally. https://academic.oup.com/jn/article-abstract/143/7/1028/4637649
• Boyer SW, Beaudin AE, Forsberg EC. (2012) Mapping stem cell differentiation pathways from hematopoietic stem cells using Flk2/Flt3 lineage tracing.  Cell Cycle, 11(17): 3180-8. https://www.tandfonline.com/doi/abs/10.4161/cc.21279
• Beaudin AE, Perry CA, Stabler SP, Allen RH, Stover PJ. (2012) Maternal Mthfd1 Disruption Impairs fetal growth but does not cause NTDs in mice.  American Journal of Clinical Nutrition, 95(4):882-91.  https://academic.oup.com/ajcn/article/95/4/882/4576775
• Beaudin AE, Abarinov EV Malysheva O, Caudill MA, Stabler SP, Allen RH, Stover PJ. (2012) Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knock-out mice.  American Journal of Clinical Nutrition, 95(1):109-14. https://academic.oup.com/ajcn/article/95/1/109/4576491

Comment in: Shane, B. (2012) Folate-responsive birth defects: of mice and women. American Journal of Clinical Nutrition 95(1):1-2.

• Beaudin AE, Abarinov EV, Noden DM, Perry CA, Chu S, Stabler SP, Allen RH, Stover PJ. (2011) Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.  American Journal of Clinical Nutrition, 93(4):789-98. https://academic.oup.com/ajcn/article/93/4/789/4597709
• Beaudin AE, Stover PJ (2009) Insights into metabolic mechanisms underlying folate-responsive neural tube defects - A minireview.  Birth Defects Research, Part A: Clinical and Molecular Teratology, 85(4):274-84.  https://onlinelibrary.wiley.com/doi/abs/10.1002/bdra.20553
• Beaudin AE, Stover PJ. (2007) Folate-mediated one carbon metabolism and neural tube defects: balancing genome synthesis and gene expression.  Birth Defects Research Part C: Embryo Today,;81(3):183-203.  https://onlinelibrary.wiley.com/doi/abs/10.1002/bdrc.20100
• Moon J, Beaudin AE, Verosky S, Driscoll LL, Weiskopf M, Levitsky DA, Crnic LS, Strupp BJ. (2006) Attentional dysfunction, impulsivity, and resistance to change in a mouse model of Fragile X syndrome.  Behavioral Neuroscience, 120(6):1367-79. 
• Lauay C, Komorowski R, Beaudin AE, DeVoogd TJ. (2005) Adult female and male zebra finches show distinct patterns of spine deficits in the song system when reared without exposure to normal adult song.  Journal of Comparative Neurology, 487(2):119-26.