- Maria Bettini Lab
The focus of research in my laboratory are the mechanisms of tolerance and their failure in autoimmunity. In order to understand pathways leading to immune dysregulation we are using a combination of innovative mouse models of T cell biology and autoimmunity, including mouse and human single T cell receptor “retrogenic” mice.
- Matt Bettini Lab
The foundation of my research centers around neonatal tolerance to organ specific antigens and microbiota.
- Jessica Brown Lab
My lab’s goal is to explain why the complex network of interactions between a host and an opportunistic pathogen only sometimes results in a stable infection.
- Sherwood Casjens Lab
The Casjens laboratory is studying the genetic control of the assembly and function of virus particles, the modular evolution of bacteriophage genomes, and the genome structure, replication and diversity of the Lyme disease causing bacteria, Borrelia burgdorferi.
- Julio Delgado Lab
The focus of our research is to understand the functional role of the HLA system in the setting of transplantation and susceptibility to disease.
- Kimberley Evason Lab
The overarching goal of the Evason laboratory is to investigate mechanisms involved in liver tumorigenesis in order to develop improved therapies to treat this deadly cancer. A major subset of HCC is defined by mutations in the CTNNB1 gene encoding β-catenin, an integral component of the Wnt signaling pathway . These β-catenin-activated HCC represent 20-40% of human HCC, and our current research focuses primarily on these tumors.
- Brian Evavold Lab
The Evavold Lab is focused on studying how T cells interact with their antigens.
- Keke Fairfax Lab
IL-4 and immuno-modulation are hallmarks of parasitic infections, my laboratory broadly focuses on using the helminth parasite Schistosoma mansoni as a tool to understand both, the consequences of IL-4 induced immuno-modulation, and the complex interplay between B, T, and stromal cells necessary to develop an optimal T and B cell memory response.
- Mark Fisher Lab
We are focused on using microbial genetics to dissect the complex interaction between Yersinia pestis, the bacterial cause of plague, and its arthropod vectors.
- Robert Fujinami Lab
Dr. Fujinami investigates animal models for human disease. Using these models he investigate ways to modulate the disease. The disease he mainly studies is multiple sclerosis. He has genetically engineered a virus that will protect mice from getting a multiple sclerosis-like disease. Recently he expanded his studies to include studying the immune response to various viruses and “self” proteins in individuals with autism. He is also establishing a new virus induced model for epilepsy and examining how the innate immune response to the virus infection contributes to seizures.
- Allie Grossmann Lab
Our laboratory focuses on understanding mechanisms of cancer progression and developing clinical interventions. Our goals are to 1) uncover novel mechanisms of tumorigenesis and metastasis, 2) identify biomarkers that prognosticate disease progression or predict treatment response and 3) collaborate with industry to develop new therapies for the prevention and treatment of cancer progression.
- Hans Haecker Lab
The major focus of our lab is on innate immunity and inflammation, with projects ranging from molecular mechanisms of signal transduction to translational aspects of drug development. We explore how innate immune cells recognize and respond to pathogens, how genetic mutations in innate immunity contribute to inflammatory and auto-immune diseases, and how obtained information can be used to develop novel therapeutic strategies.
- Scott Hale Lab
My laboratory studies T cells and their role in the generation of immunological memory in response to viral infection and immunization.
- Xiao He Lab
We are interested in identifying and characterizing the genes that regulate the functions of T lymphocytes and ultimately applying the new findings to improve diagnosis and treatment of related human diseases.
- Histocompatibility and Immunogenetics Laboratory
The Histocompatibility and Immunogenetics Laboratory provides a complete range of diagnostic testing services used primarily in the field of clinical organ transplantation and for study of associations between certain diseases and several HLA alloantigens.
- Harry Hill Lab
Dr. Hill, in association with two superb molecular biologists at the University of Utah, Dr. Carl Wittwer and Dr. Karl Voelkerding, has begun to explore molecular aspects of primary immune deficiency diseases.
- Peter Jensen Lab
The Jensen laboratory is focused on antigen processing and presentation and the role of classical and nonclassical histocompatibility (MHC) molecules in regulating immune responses.
- Beatrice Knudsen Lab
Our multidisciplinary research group at the University of Utah utilizes digital and computational pathology to explore and quantify tissue architecture.
- Lamb Lab
We work on malaria, a disease caused by infection with parasites of the genus Plasmodium. Plasmodium parasites invade the body’s red blood cells and can cause a harmful systemic infection.
- Matt Mulvey Lab
We wish to define how strains or uropathogenic Escherichia coli (UPEC) and related bacterial pathogens colonize host tissues and persist in the face of numerous innate and adaptive defenses.
- Ryan O'Connell Lab
Our laboratory is exploring the function of non-coding RNAs (including microRNAs) during inflammatory responses. Furthermore, we are investigating why disruptions in non-coding RNA expression or function is linked to human diseases such as autoimmunity and cancer.
- Sue Ostrand-Rosenberg Lab
Dr. Ostrand-Rosenberg has more than 40 years of experience as the PI of a laboratory studying the immune system’s response to cancer.
- Vicente Planelles Lab
Pathogenesis by the human immunodeficiency virus: how HIV induces alterations in the cell cycle of the host cells, leading to programmed cell death.
- June Round Lab
We work on understanding how commensal bacteria shape host immune system development and responses.
- Eric Snyder Lab
Our overall goal is to determine how the loss of cellular identity and acquisition of alternative differentiation states contributes to cancer progression and alters therapeutic response.
- Dean Tantin Research Lab
Our interests lie in the elucidation of mammalian transcription factor function and in understanding transcription factor circuitries.
- Diane Ward Lab
My laboratory studies iron metabolism specifically compartmentalization and utilization and membrane trafficking and the regulation of endosome/lysosome size.
- Janis Weis Lab
My laboratory studies the pathogenesis of Lyme disease; an infection caused by the tick borne spirochete Borrelia burgdorferi.
- Matthew Williams Lab
The research of my lab is focused on the mechanisms driving the development of long-lived immunological memory following bacterial or viral infection.