Skip to main content

     

    Serum Panel Panel Test Components-Inclusive Other Panels and Individual Test

    Immunobullous Disease Antibody Panel

    Basement Membrane Zone (Epithelial) Antibodies, IgG* +/- IgG4 by IIF 

    Basement Membrane Zone (Epithelial) Antibodies, IgA by IIF 

    Bullous Pemphigoid (BP180 and BP230) Antibodies, IgG by ELISA

    Type VII Collagen Antibody, IgG by ELISA

    (Preferred initial diagnostic panel for suspected epithelial antibody-associated disease in patients with blisters, pruritus, urticaria, eczema, and/or mucositis; with potentially overlapping epithelial antibody expression, or without distinguishing clinical features; consider with additional testing, Laminin 332 and p200 Antibodies, IgG by IIF and/or Dermatitis Herpetiformis Antibody Panel testing)  
       
       
       
       
       
       
       

    Immunodermatology Laboratory Test Reports

    Immunodermatology Laboratory Test Reports are organized to provide tiered information starting with the abstracted Diagnostic Interpretation (critical for clinical relevance), followed by the data obtained from the testing in Results, and then Comments regarding the specific findings and the testing generally with Testing Methods at the report end.  Charts, Graphs, or Images may follow for additional information.

    The Clinical Information provided by the ordering Clinician is necessary for a relevant interpretation and pertinent comments including further testing recommendations, if indicated.

    Serum Test Report Guide

    Specimen Details
    _________________________________________________
    This includes specimen identification with collected and
    received dates and ordered testing.
    _________________________________________________

    Clinical/Diagnostic Information
    This content is provided by the ordering clinician and 
    includes the reason for testing. (Note: Clinical information is
    critical for accurate and relevant interpretation and comments.)

    DIAGNOSTIC INTERPRETATION
    This is a synopsis of key findings from the testing and 
    their diagnostic relevance.
    _________________________________________________

    RESULTS
    This section reports the discrete finding and value of each 
    test component, along with the reference range.
    _________________________________________________

    COMMENTS (Specific)
    These comments provide an explanation of the test results  
    as they relate to clinical considerations and include 
    reference to any concurrent and/or previous testing.

    ELISA RESULTS GRAPH
    ------------------------------------------------------------
    A trend graph of ELISA results is included if previous and/or 
    concurrent testing has been performed demonstrating increased
    antibody levels; the graph may be found on a subsequent page.

    TEST RESULTS SUMMARY CHART
    ------------------------------------------------------------
    A chart tabulating results of tests is included if previous
    and/or concurrent testing has been performed.

    COMMENTS (General) 
    These comments summarize information about the test(s)
    performed and the component(s) assessed to aid in 
    interpretation of their clinical applicability.
    _________________________________________________

    TESTING METHODS
    The section lists the procedures performed, the test     
    source(s), and the applicable laboratory-developed test 
    disclaimer(s).
     

    Tissue Biopsy Test Report Guide

    Specimen Details
    _________________________________________________
    This includes specimen identification with collected and received
    dates.
    _________________________________________________

    Specimen(s)
    This is a description of body location and whether it is 
    lesional or perilesional for each specimen. (Note: Biopsy site
    and adequate tissue are critical for accurate diagnostic findings.)

    Clinical/Diagnostic Information
    This content is provided by the ordering clinician and 
    includes the reason for testing.

    DIAGNOSTIC INTERPRETATION
    This is a synopsis of key findings from the testing and 
    their diagnostic relevance.
    _________________________________________________

    RESULTS
    This section reports the discrete finding for each test
    component on each specimen, which, for direct 
    immunofluorescence, includes IgG, IgG4, IgM, IgA, third
    component of complement (C3), and fibrinogen.

    RESULT IMAGES (only included and available when applicable)
    Images of unusual, select positive, and/or special interest findings* are displayed in this section and may be found on the subsequent page. (High resolution, color digital files of the images may be requested by contacting the University of Utah Immunodermatology Laboratory.)

    * Note that immunofluorescence-stained tissue slides are not kept longer than two weeks after testing because fluorescence fades and patterns become indiscernible; therefore, additional images cannot be acquired after that time without retesting.
    _________________________________________________

    COMMENTS
    The comments provide an explanation of the test results as 
    they relate to clinical considerations and may include 
    recommendations to correlate with other testing, including 
    serum testing, to enhance diagnostic sensitivity.
    _________________________________________________
        
    TESTING METHODS
    The section summarizes the procedures performed, the 
    interpretation schema, and the applicable laboratory-developed 
    test disclaimer.
     

    Serum Test Report Examples

    •Immunobullous Disease Antibody Panel

    •Basement Membrane Zone Antibody Panel

    •Pemphigus Antibody Panel, IgG

    Tissue Biopsy Test Report Examples

    •Direct Immunofluorescence

    •Eosinophil Granule Major Basic Protein 1

     

    Board Certified

    John J. Zone, M.D.,  Kristin M. Leiferman, M.D., and Melanie K. Kuechle, M.D. are American Board of Dermatology Diplomats in Dermatology and Dermatological Immunology / Diagnostic and Laboratory Immunology. Mazdak A. Khalighi,  M.D. and Margaret M. Cocks, Ph.D., M.D. are American Board of Pathology Diplomats in Anatomic Pathology. Dr. Khalighi additionally has fellowship training and faculty experience in Renal Pathology/Immunopathology. Dr. Cocks additionally is an American Board of Pathology Diplomat in Clinical Pathology and is an American Board of Dermatology Diplomat in Dermatology and Dermatopathology. Drs. Khalighi and Cocks have had specialized, fellowship-equivalent training in laboratory immunodermatology by Drs. Zone and Leiferman.