Skip to main content

Selected Recent Publications (Out of 184)


  1. Stoller ML, Basak I, Denorme F, Rowley JW, Alsobrooks J, Parsawar K, Nieman MT, Yost CC, Hamilton JR, Bray PF, Campbell RA. Neutrophil cathepsin G proteolysis of protease activated receptor 4 generates a novel, functional tethered ligand. Blood Adv, In Press.
  2. Bhatlekar S, Jacob S, Tugolukova E, Manne BK, Kosaka Y, Loher P, O’Connell RM, Planelles V, Rondina MT, Rigoutsos I, Bray PF. Interferon alpha-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation. Haematologica 2021 Online ahead of print. PMID: 34758609
  3. Bhatlekar S, Jacob S, Manne BK, Guo l, Denorme F, Tuglokova EA, Cody MJ, Kosaka Y, Rigoutsos I, Campbell RA, Rowley JW, O’Connell RM, Bray PF. Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet Count without altering platelet function. Blood Cells, Molec and Dis 2021 92:102624. PMID: 34775219
  4. Loher P, Karathanasis N, Londin E, Bray P, Pliatsika V, Telonis AG, Rigoutsos I. IsoMiRmap – fast, deterministic, and exhaustive mining of isomiRs from short RNA-seq datasets. Bioinformatics 2021 37(13):1828-1838. PMID: 33471076
  5. Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O’Connell RM, Rondina MT, Campbell RC, Bray PF. miR-125a-5p regulates megakaryocyte proplatelet formation via the actin bundling protein L-plastin. Blood 136: 1702–1703, 2020. PMID: 32844999; PMCID: PMC7544541
  6. Botero JP, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, Luo M, Mohan S, Ross JE, Bergmeier W, Di Paola J; ClinGen Platelet Disorder Variant Curation Expert Panel. Glanzmann thrombasthenia: genetic basis and clinical correlates. Haematologica 2020 Apr;105(4):888-894. PMID: 32139434
  7. Rondina M, Voora D, Simon L, Schwertz H, Harper J, Lee O, Bhatlekar S, Li Q, Eustes AS, Montenont E, Campbell RA, Tolley N, Kosaka Y, Weyrich A, Bray PF, Rowley JW. Longitudinal RNA-seq analysis of the repeatability of gene expression and splicing in human platelets identifies a platelet SELP splice QTL. Circ Res 126:501-516, 2020. PMID: 31852401
  8. Megy K, Downes K, Simeoni I, Bury L, Morales J, Mapeta R, Bellissimo DB, Bray PF, Goodeve AC, Gresele P, Lambert M, Reitsma P, Ouwehand WH, Freson K; Subcommittee on Genomics in Thrombosis and Hemostasis. Curated disease-causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH. J Thromb Haemost 17:1253-1260, 2019. PMID: 31179617
  9. Bhatlekar S, Basak I, Edelstein LC, Campbell RA, Lindsay CR, Ma L, Italiano Jr. JE, Weyrich AS, Rowley JW, Rondina MT, Sola-Visner M, Bray PF. Anti-apoptotic Bcl-w increases functional megakaryocytes and proplatelet formation in cultures of human cord blood. Haematologica 104:2075-2083, 2019. PMID: 30733267
  10. Basak I, Bhatlekar S, Manne BK, Stoller M, Hugo S, Kong X, Ma L, Rondina MT, Weyrich AS, Edelstein LC, Bray PF. miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. J Thromb Haemost 17:511-524, 2019. PMID: 30632265
  11. Rowley JR, Bray PF, Weyrich AS. Platelet transcriptome. In Platelets, A Michelson, Ed., Academic Press, San Diego, 2019.
  12. Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF.  The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin, protease-activated receptor 4 desensitization, and is blocked by noncompetitive P2Y12 inhibition.  J Thromb Haemost 16:2501-14, 2018.  PMID:30347494
  13. Tricoci P, Neely M, Whitley M, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, White H, Van de Werf F, Jennings LK, Wallentin L, Held C, Harrington RA, Mahaffey KW, Bray PF.  Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: analysis from the TRACER trial. Blood Cells Molec Dis 72:37-43, 2018. PMID: 30055940
  14. French SL, Thalmann C, Bray PF, Macdonald LE, J Murphy AJ, Sleeman MW, Hamilton JR.  A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyper-reactive PAR4 variant.  Blood Adv 2:1283-1293, 2018. PMID: 29884748
  15. Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall G, Holinstat M.  A genetic variant in human PAR4 enhances ex vivo thrombus formation resulting in resistance to antiplatelet therapeutics.  Arterioscler Thromb Vasc Biol 38:1632-1643, 2018. PMID: 29748334
  16. Kong X, Simon LM, Holinstat M, Shaw CA, Bray PF, Edelstein LC.  Identification of a functional genetic variant responsible for racially dimorphic gene expression of the thrombin receptor regulator, PCTP. Thromb Haemost 117:962-970, 2017. PMID: 28251237
  17. Simon LM, Chen ES, Edelstein LC, Kong X, Bhatlekar S, Rigoutsos I, Bray PF*, Shaw CA*.  Novel alternative start site in Mitofusin-2 revealed by integrative multi-omic analysis of human platelet eQTLs. Am J Hum Genet 98:883-97, 2016. *corresponding authors.
  18. Smyth SS, Whiteheart S, Italiano, Jr JE, Bray PF, Coller BS.  Platelets. In Williams Hematology, Ninth Edition, McGraw-Hill, 2015.19.
  19. Holinstat M and Bray PF. Emerging innovative therapeutic approaches to protease receptor antagonism. Clin Pharmacol Ther 99:72-81, 2015.
  20. Buitrago L, Rendon A, Liang Y, Simeoni I, Negri A; ThromboGenomics Consortium, Filizola M, Ouwehand WH, Coller BS.  αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia. Proc Natl Acad Sci USA 112:E1898-907, 2015.
  21. Londin, Lohera P, Telonis AG, Quann K, Clark P , Jing Y , Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CES, Knudsen K, Gomella L, Spaeth GL, Hark L, Katz J, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw C, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs.  Proc Natl Acad Sci USA 112:E1106-15, 2015.
  22. Edelstein LC, Simon LM, Lindsay CR, Kong X, Montoya RT, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF.  Racial variation in the human platelet PAR4 thrombin receptor alters platelet function. Blood 124:3450-8, 2014.
  23. Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat MA, Shaw CA,  McKenzie SE, Edelstein LC, Bray PF.  microRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression. PLoS One 16;9(7):e102259, 2014.
  24. Simon LM, Edelstein LC, Nagalla S, Bergeron A, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw C, Bray PF.  Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated Plateletomics. Blood 123: e37-45, 2014.
  25. Edelstein LC, Simon LM, Montoya RT, Holinstat M, Chen ES, Bergeron A, Kong X, Nagalla S, Mohandas N, Cohen DE, Dong J-f, Shaw C, Bray PF.  Racial difference in human platelet PAR4 reactivity reflects expression of PCTP and miR-376c. Nat Med 19:1609-16, 2013; PMID: 24216752
  26. Edelstein LE, McKenzie SE, Holinstat MA, Kunapuli SP, Bray PF.  MicroRNAs in platelet production and activation. J Thromb Haemost Suppl 1:340-50, 2013.
  27. Bray PF, Jones CI, Soranzo N, Ouwehand WH.  Platelet Genomics.  In Platelets, A Michelson, Ed., Academic Press, San Diego, 2013.
  28. Edelstein LC, Luna EJ, Gibson I, Bray M, Jin Y, Kondkar A, Nagalla N, Hadjout-Rabi N, Smith TC, Covarrubias D, Jones SN, Ahmad F, Kong X, Fang Z, Bergmeier W, Shaw CA, Leal SM, Bray PF.  Human genome-wide association and mouse knock-out approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation 125:2762-71, 2012.  
  29. Nagalla S, Shaw C, Kong X, Kondkar AA, Edelstein LC, Ma L, Chen J, McKnight GS, López JA, Yang L, Jin Y, Bray MS, Leal SM, Dong JF, Bray PF.  Platelet microRNA-mRNA co-expression profiles correlate with platelet reactivity. Blood 117:5189-97, 2011.
  30. Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P, Chen HW, Fortina P, Rigoutsos I.  The complex transcriptional landscape of the anucleate human platelet. BMC Genomics 14:1, 2013