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  1. To investigate the role of microsomal prostaglandin E synthase 1 (mPGES-1) in regulation of fluid metabolism and blood pressure;
  2. To investigate potential interaction of PGE2 and intrarenal renin-angiotensin system during angiotensin II-induced hypertension and kidney disease;
  3. To investigate the role of PPAR gamma in regulation of fluid metabolism and cardiovascular function
  4. To investigate therapeutic potential and mechanism of nitro lipids in metabolic and renal diseases.


Our lab is currently funded by NIH and VA Merit Review grants:

  1. mPGES-1/EP1 in Volume Regulation, VA Merit Review
  2. Control of Collecting Duct Function by Lipid-derived Factors in Obesity, R01, NIDDK.
  3. Nitrated Fatty Acids/PPAR gamma in the Control of Renal and Vascular Functions. R01, NIDDK.

Tianxin Yang, MD, PhD


Nephrology & Hypertension

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