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Peer-reviewed publications (selected from 101 publications).

1. Zhang H,  Zhang A,  Donald E. Kohan DE, Nelson RD,  Gonzalez FJ, and Yang T.  Collecting-duct-specific deletion of PPARγ blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci U SA  102:9406-9411, 2005
2. Sakuma Y, Nonoguchi H, Takayama M, Yang T, Terada Y, Inoue T. Nakayama Y, Kohda Y, Sasaki S, and Tomita K.  Differential effects of hyperosmolality on Na-K-ATPase and vasopressin-dependent cAMP generation in the medullary thick ascending limb and outer medullary collecting duct. Hypertens Res. 28:671-9, 2005
3. Paliege A, Pasumarthy A, Mizel D, Yang T, Schnermann J, and Bachmann S. Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats. Am J Physiol Regul Inter Comp Physiol  290: R694-700, 2006
4. Ye W,  Zhang H,  Hillas E, Lalouel JM, Miller RL,  Nelson RD,  and Honeggar M, and Yang T. Expression and function of COX isoforms in the renal medulla: evidence for regulation of salt sensitivity and blood pressure. Am J Physiol-Renal 290: F542-9, 2006
5. Guo X and Yang T. Endothelin B receptor antagonism in the rat renal medulla reduces urine flow rate and sodium excretion. Experimental Biology and Medicine  231:1001-5, 2006
6. Yang T,  Zhang A,  Pasumarthy A, Warnock Z, and Schnermann JB. Nitric oxide stimulates COX-2 expression in cultured collecting duct cells through MAP kinases but not cGMP. Am J Physiol-Renal 291:F891-5, 2006
7. Zhang A, Wang M-H, Dong Z, and Yang T. Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: Interaction with hepatocyte growth factor. Am J Physiol-Renal 291:F1323-31, 2006
8. Zhang A, Dong Z, and Yang T. Prostaglandin D2 inhibits epithelial-to-mesenchymal transition in cultured MDCK cells. Am J Physiol-Renal  291:F1332-42, 2006
9. Jia Z, Zhang A, Zhang H, Dong Z, and Yang T. Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion.  Cir. Res. 99:1243-51, 2006
10. Jiang M, Wei Q, Pabla N, Dong G, Wang CY, Yang T, Smith SB, and Dong Z. Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Bichem Pharmacol 73:1499-1510, 2007
11. Brooks C, Wang J, Yang T, and Dong Z. Characterization of cell clones isolated from hopoxia-selected renal proximal tubular cells. Am J Physiol-Renal 292:F243-52, 2007
12. Jiang M, Pabla N, Murphy RF, Yang T, Yin XM, Degenhardt K, White E, and Dong Z. Nutlin-3 protect kidney cells during cisplatin therapy by suppressing Bax/Bak activation. J Biol Chem 282:2636-45, 2007
13. Huang H,  Morisseau  C, Wang J, Yang T,  Falck J, Hammock B,  Wang M-H. Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese Rats. Am J Physiol-Renal 293:F342-9, 2007
14. Zhang A, Jia Z, Guo X, and Yang T. Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin. Am J Physiol-Renal 293:F723-31,  2007
15. Wei Q, Dong G, Yang T, Megyesi J, Price P, Dong Z. Activation and involvement of p53 in cisplatin-induced nephrotoxicity. Am J Physiol-Renal 293:F1282-91, 2007
16. Ge Y, Strait KA, Stricklett PK, Yang T, and Kohan DE. Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion.  Am J Physiol-Renal 293:F1805-10, 2007
17. Soodvilai S and Yang T. Hydrogen peroxide stimulates chloride secretion in primary  inner medullary collecting duct cells via mPGES-1-derived PGE2. Am J Physiol-Renal 293:F1571-6, 2007
18. Ding G,  Zhang A, Huang S, Pan X, Chen R, and Yang T.  Angiotensin II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGF receptor. Am J Physiol-Renal 293:F1889-97, 2007
19. Liu H, Ye W, Guan G, Jia Z, and Yang T.  Developmental regulation of calcineurin isoforms in the rodent  kidney: association with COX-2.  Am J Physiol-Renal 293:F1898-904, 2007
20. Oong G, Lash  L, Wang L, Wang CY,  Yang T,  Kumar V, and  Dong Z. Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agent. J Pharmacol  Exp  Ther Ther 325:978-84, 2008
 21. Zhou Y, Luo P, Chang HH, Huang H, Yang T, Dong Z, Wang CY, and Wang M-H. Activation of PPARα by clofibrate attenuates hypertension and sodium retention in DOCA-salt-treated mice. Kidney Int  74:1040-8, 2008
22. Ye F, Jeong EK, Jia Z, Yang T, Parker D, Lu ZR. A peptide targeted contrast agent specific to
fibrin-fibronectin complexes for cancer molecular imaging with MRI. Bioconjugate Chem. 19:2300-2303, 2008.
23. Liu H, Jia Z, Soodvilai S, Guan G, Wang M-H, Dong Z,  Symons JD, and Yang T. Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury Am J Physiol-Renal  295:F942-9, 2008
24. Jia Z and Yang T. Antioxidant activity of mPGES-1-derived PGE2 confers protection against
 angiotensin II-induced vasoconstriction. Hypertension  52:952-9, 2008
25. Wang N, Yang G, Jia Z, , Zhang H, Soodvilai S, Symons JD, Gonzalez FJ, Litwin SE, and Yang T.
Vascular PPARγ controls circadian variation of blood pressure and heart rate via activation of
 Bmal1.  Cell Metab 2008 8:482-91, 2008
26. Wang N, Symons JD, Jia Z, Gonzalez FJ, and Yang T.  Distinct functions of vascular endothelial
and smooth muscle PPARγ in regulation of blood pressure and vascular tone. Toxicol Pathol. 37:21-7, 2009
27. Chen Q, Xu S,  Huang S, Zhang A, Feng Q, Guo X, Guo M, Yang T, and Chen R.  Suppression subtractive hybridization analysis of gene expression during late kidney development identifies the developmentally regulated gene rPEA3.  Nephron Exp Nephrol 111:103-115, 2009.
28. Feng Q, Huang S, Zhang A, Chen Q, Guo X,  Chen R, and Yang T. Y-Box protein 1 stimulates mesangial cell proliferation via activation of ERK1/2. Nephron Exp Nephrol 113:e16-e25, 2009
29. Jiang M, Huang   S, Yang T,  Wang CY, and Dong Z. Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway. Am J Physiol-Renal 296:F983-93, 2009
Soodvilai S, Jia Z, and Yang T. mPGES-1 deletion impairs diuretic response to acute water loading. Am J Physiol-Renal 296:F1129-35, 2009
30. Jia Z, Wang H, and Yang T. Mice lacking mPGES-1 are resistant to lithium-induced polyuria
Am J Physiol-Renal 297:F1689-96, 2009
31. Jia Z, Aoyagi T, and Yang T. mPGES-1 protects against DOCA-salt hypertension via inhibition of oxidative stress and/or stimulation of NO/cGMP. Hypertension 55:539-46, 2010
32. Wang H, Liu H, Jia Z, Olsen C, Litwin S, Guan G, and Yang T. Nitro-oleic acid protects against endotoxin-induced endotxemia and multi-organ injury in mice. Am J Physiol-Renal  298:F754-62, 2010
33. Tanner JM, Kim BJ, Kearns DT, Sloan C, Jia Z, Yang T, Abel ED, and  Symons JD. Cardiovascular and metabolic responses to fasting in obese vs. lean C57BL/6J mice. Experimental Biology and Medicine 235(12):1489-97, 2010
34. Wang H, Liu H, Jia  Z, Guan G, and  Yang T.  Effects of endogenous PPAR agonist nitro-oleic acid on metabolic syndrome in obese Zucker rats. PPAR Research 2010:601562, 2010
35. Jia Z     Jia Z, Aoyagi T, Kohan DE, Yang T.. mPGES-1 deletion impairs aldosterone escape and enhances sodium appetite. Am J Physiol Renal Physiol. 299(1):F155-66, 2010.
36. Jia Z, Wang N, Aoyagi T, Liu H, and Yang T. Amelioration of cisplatin nephrotoxicity by genetic or pharmacologic blockade of prostaglandin synthesis. Kidney Int  79(1):77-88, 2011
37. Brooks C, Cho SG, Wang CY, Yang T, and Dong Z. Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. Am J Physiol Cell Physiol Physiol. 300(3):C447-55, 2011.
38. Zhang A, Jia  Z, Wang N, Tidwell TJ,  and Yang T.  Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice. Kidney Int  80(1):51-60, 2011
39. Zhu C, Huang S, Yuan Y, Ding G, Chen Y,  Yang T and Zhang A. Mitochondrial dysfunction mediates aldosterone-induced podocyte damage:  A therapeutic target PPARγ.  Am J Pathol. 178(5):2020-31, 2011.
40. Eisner C, Ow H, Yang T, Jia Z, Dimitriadis E, Li L, Wang K, Briggs J, Levine M,  Schnermann J and Espey MG. J Appl Physiol In press 2012
41. Jia Z, Wang H, and Yang T. Distinct roles of mPGES-1 in mediating inflammatory responses and timulating erythropoietin expression in the 5/6 nephrectomy mouse model. Hypertension 59:122-8, 2012
42. Jia Z,  Liu G, Dong Z, Zhang A, and Yang T. mPGES-1 deletion potentiates urine concentrating capability  after water deprivation. AJP-Renal 302:F1005-12, 2012
43. Yang G, Jia Z,  Aoyagi T, McClain D,. Mortensen RM, and Yang T. Systemic PPARγ deletion impairs circadian rhythms of behavior and metabolism. PLoS ONE In press 2012
44. Yuan Y, Chen Y, Zhang P, Huang S, Zhu C, Ding G, Liu B, Yang T, Zhang A. Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells. Free Radic Biol Med In press 2012
45. Yuan Y, Huang S, Wang W, Wang Y, Zhang P, Zhu C, Ding G, Liu B, Yang T, Zhang A. Activation of peroxisome proliferator-activated receptor-γ coactivator 1α ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury. Kidney Int. In press 2012
46. Soodvilai S, Jia Z, Fongsupa S, Chatsudthipong V, and Yang T. Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. AJP-Renal 303:F1610-6, 2012
47. Jia Z, Liu G, Sun Y, Kakizoe Y, Guan G, Zhang A, Zhou SF, and Yang T. mPGES-1-derived PGE2
mediates dehydration natriuresis. AJP-Renal 304:F214-21, 2013
48. Liu S, Jia Z, Zhou Z, Liu Y, Ling H, Zhou SF, Zhang A, Du Y,Guan G, and  Yang  T. Nitro-oleic acid protects against adriamycin-induced nephropathy in mice. AJP-Renal 305:F1555-62, 2013
49. Yin JJ, Sharma S, Shumyak SP,  Wang ZX, Zhou ZW, Zhang Y, Guo P, Li CZ,  Kanwar JR, Yang T, Mohapatra SS, Liu W,  Duan W, Wang JC, Li Q,  Zhang X, Tan J,  Jia L, Liang J,  Wei MQ, Li X, and Zhou SF. Synthesis and biological evaluation of novel folic acid receptor-targeted, beta-cyclodextrin-based drug complexes for cancer treatment. PLoS One  In press
50. Su M, Dhoopun AR, Yuan Y, Huang S, Zhu C, Ding G, Liu BC, Yang T, Zhang A. Mitochondrial dysfunction is an early event in aldosterone-induced podocyte injury. AJP-Renal  305:F520-31, 2013  
51. Zhou L, Liu L, Jia Z, Yang K, Sun Y, Kakizoe Y, Liu M, Zhou SF, Chen R, Yang B, and Yang T.  Increased Susceptibility of db/db mice to rosiglitazone-induced plasma volume expansion: role of dysregulation of renal water transporters. AJP-Renal 305:F1491-7, 2013
52. Liu Y, Jia Z, Liu S, Downton M, Liu G, Du Y, and Yang T. Combined losartan and nitro-oleic
acid remarkably improves diabetic nephropathy in mice. AJP-Renal 305:F1555-62, 2013

Tianxin Yang, MD, PhD


Nephrology & Hypertension

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