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Phase Aberration Correction

The breast has a unique structure and composition that varies from individual to individual. According to the American College of Radiology’s Breast Imaging Reporting and Data System (BI-RADS),  there are four breast density classifications. Large-scale population-based data show that the majority of breasts are highly heterogeneous, a mixed composition of breast fat and fibroglandular tissues. These two tissue types have quite different speeds of sound which can result in aberration of the focused ultrasound beam during focused ultrasound treatments. Our lab has worked to develop treatment planning techniques for breast MRgFUS therapies, including developing and validating phase aberration correction methods and quantitatively verifying the accuracy of our rapid acoustic modeling algorithm. 

Related Publications

Odéen H. and Parker DL (2019). Magnetic resonance thermometry and its biological applications - Physical principles and practical considerations. Progress in NMR Spectroscopy. 110:34-61.

Diakite, M., Odéen, H., Todd, N., Payne, A., & Parker, D. L. Toward real‐time temperature monitoring in fat and aqueous tissue during magnetic resonance–guided high‐intensity focused ultrasound using a three‐dimensional proton resonance frequency T1 method .Magn Reson Med. 2014;72(1):178-187.

Diakite M, Payne A, Todd N, Parker DL. Irreversible change in the T1 temperature dependence with thermal dose using the proton resonance frequency-T1 technique .Magn Reson Med. 2013;69(4):1122-30.

Odeen H, Almquist S, de Bever J, Christensen DA, Parker DL. MR thermometry for focused ultrasound monitoring utilizing model predictive filtering and ultrasound beam modeling .Journal of therapeutic ultrasound. 2016;4:23.

Odeen H, de Bever J, Almquist S, Farrer A, Todd N, Payne A, et al. Treatment envelope evaluation in transcranial magnetic resonance-guided focused ultrasound utilizing 3D MR thermometry. Journal of therapeutic ultrasound. 2014;2:19.

Svedin BT, Payne A, Bolster BD, Jr., Parker DL. Multiecho pseudo-golden angle stack of stars thermometry with high spatial and temporal resolution using k-space weighted image contrast. Magn Reson Med. 2018;79(3):1407-19.

Todd N, Adluru G, Payne A, DiBella EV, Parker D (2009). Temporally constrained reconstruction applied to MRI temperature data. Magn Reson Med. 62(2), 406-19.

Todd N, Payne A, Parker DL (2010). Model predictive filtering for improved temporal resolution in MRI temperature imaging. Magn Reson Med. 63(5), 1269-79.

Todd N, Vyas U, de Bever J, Payne A, Parker DL (2011). The effects of spatial sampling choices on MR temperature measurements. Magn Reson Med. 65(2), 515-21.

Todd N, Vyas U, de Bever J, Payne A, Parker DL (2012). Reconstruction of fully three-dimensional high spatial and temporal resolution MR temperature maps for retrospective applications. Magn Reson Med.  67(3), 724-30.

Todd N, Diakite M, Payne A, Parker DL (2013). Hybrid proton resonance frequency/T1 technique for simultaneous temperature monitoring in adipose and aqueous tissues. Magn Reson Med. 69(1), 62-70.

Odéen H and Parker DL (2019). Improved MR thermometry for laser interstitial thermotherapy. Lasers Surg. Med. (Early view).

Hansen M, Christensen D, Payne A (2021). Experimental validation of acoustic and thermal modeling in heterogeneous phantoms using the hybrid angular spectrum method. Int J Hyperthermia, 38(1), 1617-1626. 

Dillon CR, Farrer A, McLean H, Almquist S, Christensen D, Payne A. Experimental assessment of phase aberration correction for breast MRgFUS therapy. Int J Hyperthermia. 2018 Sep;34(6):731-743.

Farrer AI, Almquist S, Dillon CR, Neumayer LA, Parker DL, Christensen DA, Payne A. Phase aberration simulation study of MRgFUS breast treatments. Med Phys. 2016 Mar;43(3):1374-84

Members of the Focused Ultrasound Laboratory have intellectual property in this area of research. Any conflict of interest concerns can be addressed by the investigators or the department chair.