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Recent Publications (2011 onward)

Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial


Melber, A., Na, U., Vashisht, A., Weiler, B.D., Lill, R., Wohlschlegel, J.A., and Winge, D.R. (2016) eLife.

The     mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis

VanVraken, J.G., Jeong, M.-Y., Gygi, S.P., Winge, D.R., Rutter, J. (2016)  eLife in press

Cox1 mutation abrogates need for Cox23 in Cytochrome c Oxidase Biogenesis"

Dela Cruz, R., Jeong, M.-Y., Winge, D.R. (2016) Microbial Cell, in press.

The Plasma Membrane Protein Nce102 Implicated in Eisosome Formation Rescues A Heme Defect in Mitochondria.

Kim H, Jeong MY, Parnell TJ, Babst M, Phillips JD, Winge DR.

J Biol Chem. 2016 Jun 17. pii: jbc.M116.727743PMID: 27317660

Protein-mediated assembly of succinate dehydrogenase and its cofactors.

Van Vranken JG, Na U, Winge DR, Rutter J.

Crit Rev Biochem Mol Biol. 2015 Mar-Apr;50(2):168-80. doi: 10.3109/10409238.2014.990556. PMID: 25488574

The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase.

Na U, Yu W, Cox J, Bricker DK, Brockmann K, Rutter J, Thummel CS, Winge DR.

Cell Metab. 2014 Aug 5;20(2):253-66. doi: 10.1016/j.cmet.2014.05.014. PMID: 24954417

Modulation of the respiratory supercomplexes in yeast: enhanced formation of cytochrome oxidase increases the stability and abundance of respiratory supercomplexes.

Cui TZ, Conte A, Fox JL, Zara V, Winge DR.

J Biol Chem. 2014 Feb 28;289(9):6133-41. doi: 10.1074/jbc.M113.523688. PMID: 24421313

Copper import into the mitochondrial matrix in Saccharomyces cerevisiae is mediated by Pic2, a mitochondrial carrier family protein.

Vest KE, Leary SC, Winge DR, Cobine PA.

J Biol Chem. 2013 Aug 16;288(33):23884-92. doi: 10.1074/jbc.M113.470674.

PMID: 23846699

Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F.

Sandoval IT, Manos EJ, Van Wagoner RM, Delacruz RG, Edes K, Winge DR, Ireland CM, Jones DA.

Chem Biol. 2013 Jun 20;20(6):753-63. doi: 10.1016/j.chembiol.2013.05.008.

PMID: 23790486

Emerging concepts in the flavinylation of succinate dehydrogenase.

Kim HJ, Winge DR.

Biochim Biophys Acta. 2013 May;1827(5):627-36. doi: 10.1016/j.bbabio.2013.01.012.

PMID: 23380393

Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion.

Lee SH, Jouihan HA, Cooksey RC, Jones D, Kim HJ, Winge DR, McClain DA.

Endocrinology. 2013 Mar;154(3):1029-38. doi: 10.1210/en.2012-1445. PMID: 23372018

COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux.

Leary SC, Cobine PA, Nishimura T, Verdijk RM, de Krijger R, de Coo R, Tarnopolsky MA, Winge DR, Shoubridge EA.

Mol Biol Cell. 2013 Mar;24(6):683-91. doi: 10.1091/mbc.E12-09-0705. PMID: 23345593


Loss of cardiolipin leads to perturbation of mitochondrial and cellular iron homeostasis.

Patil VA, Fox JL, Gohil VM, Winge DR, Greenberg ML.

J Biol Chem. 2013 Jan 18;288(3):1696-705. doi: 10.1074/jbc.M112.428938.

PMID: 23192348


LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells.

Sánchez E, Lobo T, Fox JL, Zeviani M, Winge DR, Fernández-Vizarra E.

Biochim Biophys Acta. 2013 Mar;1827(3):285-93. doi: 10.1016/j.bbabio.2012.11.003. PMID: 23168492


Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site.

Eletsky A, Jeong MY, Kim H, Lee HW, Xiao R, Pagliarini DJ, Prestegard JH, Winge DR, Montelione GT, Szyperski T.

Biochemistry. 2012 Oct 30;51(43):8475-7. doi: 10.1021/bi301171u. PMID: 23062074


Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit.

Kim HJ, Jeong MY, Na U, Winge DR.

J Biol Chem. 2012 Nov 23;287(48):40670-9. doi: 10.1074/jbc.M112.405704.

PMID: 23043141

Late-stage maturation of the Rieske Fe/S protein: Mzm1 stabilizes Rip1 but does not facilitate its translocation by the AAA ATPase Bcs1.

Cui TZ, Smith PM, Fox JL, Khalimonchuk O, Winge DR.

Mol Cell Biol. 2012 Nov;32(21):4400-9. doi: 10.1128/MCB.00441-12. PMID: 22927643

Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2.

Khalimonchuk O, Kim H, Watts T, Perez-Martinez X, Winge DR.

J Biol Chem. 2012 Aug 3;287(32):26715-26. doi: 10.1074/jbc.M112.377200.

PMID: 22669974

Sealing the mitochondrial respirasome.

Winge DR.

Mol Cell Biol. 2012 Jul;32(14):2647-52. doi: 10.1128/MCB.00573-12. PMID: 22586278